1-(5-Chloro-2-hydroxyphenyl)ethanone

Product Name: 1-(5-Chloro-2-hydroxyphenyl)ethanone
CAS No.: 1450-74-4
Chemical Name: 1-(5-Chloro-2-hydroxyphenyl)ethanone
Synonyms: 1-(5-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-CHLORO-2-HYDROXYACETOPHENONE;1-(3-chlorophenyl)-2-hydroxyethan-1-one;AKOS BB-6937;ASISCHEM D38764;SALOR-INT L497495-1EA;2-Acetyl-4-chlorophenol;oro-2'-hydroxyacetophenone;2'-hydroxy-5'-chlorophenone;2-HYDROXY-5-CHLORO ACETOPHENONE
CBNumber: CB3482191
Molecular Formula: C8H7ClO2
Formula Weight: 170.59
MOL File: 1450-74-4.mol

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1-(5-Chloro-2-hydroxyphenyl)ethanone Property

Melting point:: 54-56 °C(lit.)
Boiling point:: 126-128 °C28 mm Hg(lit.)
Density: 1.2315 (rough estimate)
refractive index: 1.5590 (estimate)
Flash point:: 107-109°C/12mm
storage temp.: Sealed in dry,Room Temperature
form: Solid
pka: 9.72±0.18(Predicted)
BRN: 1365589
InChI: InChI=1S/C8H7ClO2/c1-5(10)7-4-6(9)2-3-8(7)11/h2-4,11H,1H3
InChIKey: XTGCUDZCCIRWHL-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(Cl)=CC=C1O)C
CAS DataBase Reference: 1450-74-4(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 383384
Product name: 5′-Chloro-2′-hydroxyacetophenone
Purity: 99%
Packaging: 5g
Price: $26.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 383384
Product name: 5′-Chloro-2′-hydroxyacetophenone
Purity: 99%
Packaging: 25g
Price: $45.79
Updated: 2025/07/31

TCI Chemical

Product number: C2119
Product name: 1-(5-Chloro-2-hydroxyphenyl)ethan-1-one
Purity: min. 98.0 %
Packaging: 5G
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: C2119
Product name: 1-(5-Chloro-2-hydroxyphenyl)ethan-1-one
Purity: min. 98.0 %
Packaging: 25G
Price: $150
Updated: 2025/07/31

TRC

Product number: C381338
Product name: 1-(5-Chloro-2-hydroxyphenyl)ethanone
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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1-(5-Chloro-2-hydroxyphenyl)ethanone Chemical Properties,Usage,Production

Chemical Properties

slightly yellow crystalline powder or chunks

Uses

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:

6-chloro-2-methyl-4H-chrome-4-one
1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
2-styrenyl allyl ether

Preparation

Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).

General Description

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.

Synthesis

876-27-7

1450-74-4

General procedure for the synthesis of 5'-chloro-2'-hydroxyacetophenone from acetic acid-4-chlorophenyl ester: Acetic acid-4-chlorophenyl ester (10 g, 0.091 mol) was placed in a 500 ml round-bottomed flask with aluminum chloride (14.56 g, 0.11 mol). The mixture was heated in an oil bath at 140-150°C for 5-6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using ethyl acetate:hexane as the unfolding agent. Upon completion of the reaction, the reaction mixture was quenched with crushed ice and the solid product was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with saturated brine solution (2 x 15 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by recrystallization from aqueous solution. The yield is 90% and the melting point is 54-56°C.

References

[1] Chinese Chemical Letters, 2016, vol. 27, # 7, p. 1058 - 1063
[2] Synthesis, 1985, # 9, p. 901 - 902
[3] Tetrahedron, 2011, vol. 67, # 3, p. 641 - 649
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 2, p. 184 - 185
[5] Indian Journal of Heterocyclic Chemistry, 2011, vol. 21, # 2, p. 151 - 156

1-(5-Chloro-2-hydroxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Chloro-2-hydroxyphenyl)ethanone Suppliers

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View Lastest Price from 1-(5-Chloro-2-hydroxyphenyl)ethanone manufacturers

Honest Joy Holdings Limited

Product: 5'-Chloro-2'-hydroxyacetophenone 1450-74-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 1-(5-Chloro-2-hydroxyphenyl)ethanone 1450-74-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

1450-74-4, 1-(5-Chloro-2-hydroxyphenyl)ethanoneRelated Search:

6-CHLOROCHROMAN-4-ONE 6,8-DICHLORO-3-FORMYLCHROMONE 5-Chloro-2-hydroxybenzophenone (+)-Griseofulvin 1-(5-Chloro-2-hydroxyphenyl)ethanone 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 2-AMINO-6-CHLORO-3-FORMYLCHROMONE MECLOCYCLINE SULFOSALICYLATE SALT Demeclocycline hydrochloride 5-CHLORO-BENZOFURAN-3-ONE Chlortetracycline hydrochloride 5-CHLORO-2-HYDROXY-4-METHYLBENZOPHENONE 1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone,1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone, 5-Chloro-3-bromo-2-hydroxyacetophenone 2-Chloro-3',4'-dihydroxyacetophenone 2-BROMO-1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE 1-(2-Chloro-6-hydroxyphenyl)ethanone 2'-Chloro-4'-hydroxyacetophenone 1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE

JRH-01003, 1-(5-Chloro-2-hydroxyphenyl)ethanone, 97%

SALOR-INT L497495-1EA

2-Acetyl-4-chlorophenol

5'-Chloro-2'-Hydroxy Acetophenone 2'-Hydorxy-5'-Chloro Acetophenone

2'-Hydorxy-5'-ChloroAcetophenone

Acetophenone, 5'-chloro-2'-hydroxy-

Acetophenone,5-chloro-2-hydroxy-

5'-Chloro-2'-hydroxyacetophenone,99%

Ethanone,1-(5-chloro-2-hydroxyphenyl)-

1-(3-chlorophenyl)-2-hydroxyethan-1-one

ASISCHEM D38764

2'-HYDROXY-5'-CHLORO ACETOPHENONE

2-HYDROXY-5-CHLORO ACETOPHENONE

1-(5-CHLORO-2-HYDROXYPHENYL)-1-ETHANONE

1-(5-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

1-(5-CHLORO-2-HYDROXYPHENYL)ETHANONE

AKOS BB-6937

5-CHLORO-2-HYDROXYACETOPHENONE

5'-Chloro-2'-hydroxyacetophenone 99%

5'-Chloro-2'-hydroxyacetophenone, 98%+

oro-2'-hydroxyacetophenone

2'-hydroxy-5'-chlorophenone

1-(5 CHOLRO-2-HYDROXYPHENYL)ETHANONE

2-HYDROXY-5-CHLOROACETOPHENONE -99+% CA

2 HYDROXY-5-CHLOROACETOPHENONE-99+%

5'-Chloro-2'-hydroxyacetophenone

2'-Hydroxy-5'-chloroacetophenone

5′-Chloro-2′-hydroxyacetophenone, CAS 1450-74-4

1450-74-4

ClC6H3OHCOCH3

Organic Building Blocks

Ketones

Building Blocks

C7 to C8

Carbonyl Compounds

Aromatic Acetophenones & Derivatives (substituted)

Phenoles and thiophenoles

Adehydes, Acetals & Ketones

Chlorine Compounds

Phenols

C7 to C8

Carbonyl Compounds

Ketones

ADVANCED INT.