ChemicalBook > CAS DataBase List > 1H-PYRROLO[2,3-B]PYRIDIN-5-OL

1H-PYRROLO[2,3-B]PYRIDIN-5-OL

Product Name
1H-PYRROLO[2,3-B]PYRIDIN-5-OL
CAS No.
98549-88-3
Chemical Name
1H-PYRROLO[2,3-B]PYRIDIN-5-OL
Synonyms
5-HYDROXY-7-AZAINDOLE;SW-63;SWF-63;5-Hydroxyazaindole;Vinetola impurity 12;5-Hydroxy-7-azaindole 97%;H-PYRROLO[2,3-B]PYRIDIN-5-OL;1H-Pyrrolo[2,3-B]Pridin-5-ol;1H-PYRROLO[2,3-B]PYRIDIN-5-OL;5-hydroxypyrrolo[2,3-b]pyridine
CBNumber
CB3484584
Molecular Formula
C7H6N2O
Formula Weight
134.14
MOL File
98549-88-3.mol
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1H-PYRROLO[2,3-B]PYRIDIN-5-OL Property

Melting point:
219-220°C
Boiling point:
381.8±42.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Powder
pka
6.93±0.20(Predicted)
Appearance
Light brown to light yellow Solid
InChI
InChI=1S/C7H6N2O/c10-6-3-5-1-2-8-7(5)9-4-6/h1-4,10H,(H,8,9)
InChIKey
VUQZKLXKFUBWRP-UHFFFAOYSA-N
SMILES
C12NC=CC1=CC(O)=CN=2
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000886
Product name
1H-Pyrrolo[2,3-b]pyridin-5-ol
Purity
Aldrich
Packaging
1g
Price
$817
Updated
2025/07/31
TRC
Product number
P998405
Product name
1H-​Pyrrolo[2,​3-​b]​pyridin-​5-​ol
Packaging
2.5g
Price
$165
Updated
2021/12/16
AK Scientific
Product number
J97232
Product name
5-Hydroxy-7-azaindole
Packaging
1g
Price
$25
Updated
2021/12/16
Apolloscientific
Product number
OR301023
Product name
5-Hydroxy-7-azaindole
Purity
97%
Packaging
1g
Price
$79
Updated
2021/12/16
ChemScene
Product number
CS-D0720
Product name
1H-Pyrrolo[2,3-b]pyridin-5-ol
Purity
98.12%
Packaging
10g
Price
$80
Updated
2021/12/16
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1H-PYRROLO[2,3-B]PYRIDIN-5-OL Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets.

Synthesis

858116-66-2

98549-88-3

General procedure for the synthesis of 1H-pyrrolo[2,3-b]pyridin-5-ol from 1-triisopropylsilyl-5-bromo-7-azaindole: To a 50 mL reaction flask at room temperature were added the compound of formula II (4.08 g, 11.5 mmol), copper acetylacetonate (0.15 g, 0.575 mmol), MHPO (0.15 g, 0.575 mmol), lithium hydroxide monohydrate (2.42 g, 57.5 mmol), 18 mL of DMSO, and 4.5 mL of water. Stirring was turned on, the air in the reaction system was replaced with nitrogen, and the reaction temperature was raised to an internal temperature of 100°C. The reaction was maintained at this temperature for 6 h. The reaction was carried out by TLC. The progress of the reaction was monitored by TLC and after confirming that the ingredients were fully reacted, the heating was stopped and the reaction mixture was cooled to room temperature (20-30°C). 100 mL of water was added to the reaction mixture and the pH was adjusted to 6 with 2 N dilute hydrochloric acid, at which point a solid precipitated. Filtering was carried out and the solid was collected. The aqueous phase was extracted with ethyl acetate (50 mL × 3) and the organic phases were combined. The organic phase was washed sequentially with water and saturated aqueous sodium chloride solution each, and then dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give the compound of formula III. Yield: 1.2 g, yield: 78.5%.

References

[1] Patent: CN107434807, 2017, A. Location in patent: Paragraph 0056-0059; 0080-0083; 0102-0106

1H-PYRROLO[2,3-B]PYRIDIN-5-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRROLO[2,3-B]PYRIDIN-5-OL Suppliers

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDIN-5-OL manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Hydroxy-7-azaindole 98549-88-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Hebei Yanxi Chemical Co., Ltd.
Product
1H-Pyrrolo[2,3-b]pyridin-5-ol 98549-88-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-13
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Venetoclax Impurity 12 98549-88-3
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-03-28

98549-88-3, 1H-PYRROLO[2,3-B]PYRIDIN-5-OLRelated Search:

tert-butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate 1-Benzylazetidin-3-ol 4-Chloro-5-fluoro-2-(Meth... Acetic acid, [(5-chloro-2-pyridinyl)aMino]oxo- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 6-BROMO-4-INDOLECARBOXYLIC ACID METHYL ESTER 6-Methoxyindole 7-Azabicyclo[2,2,1]heptane hydrochloride Diethyl 1H-pyrrole-2,4-dicarboxylate 1-Hydroxy-1-cyclopropanecarboxylic acid 3-BroMo-5-nitro-1H-pyrazo... 4-Bromo-7-azaindole 4-Chloro-7-azaindole 4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate DL-7-Azatryptophan Monohydrate 1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID

  • 5-Hydroxy-7-azaindole 97%
  • 5-hydroxypyrrolo[2,3-b]pyridine
  • 1H-PYRROLO[2,3-B]PYRIDIN-5-OL
  • 5-HYDROXY-7-AZAINDOLE
  • 1H-Pyrrolo[2,3-b]pyridin-5-ol(6CI,9CI)
  • 1H-Pyrrolo[2,3-b]pyridin-5-ol90929-73-0
  • 5-HYDROXY-1H-PYRROLO[2,3-B]PYRIDINE
  • H-PYRROLO[2,3-B]PYRIDIN-5-OL
  • 5-Hydroxyazaindole
  • 5-Hydroxy-7-azaindole Company Standards
  • 1H-pyrrolo[2,3-b]pyridin-5-ol(For export only)
  • SWF-63
  • SW-63
  • 1H-Pyrrolo[2,3-b]pyridin-5-ol (6CI, 9CI, ACI)
  • 1H-Pyrrolo[2,3-B]Pridin-5-ol
  • 1H pyrrolo [2,3, B] pyridine-5-ol
  • Vinetola impurity 12
  • 1H-Pyrrolo[2,3-B]Pyridine-5-alcohol
  • 98549-88-3
  • PYRIDINE