1H-PYRROLO[2,3-B]PYRIDIN-5-OL
- Product Name
- 1H-PYRROLO[2,3-B]PYRIDIN-5-OL
- CAS No.
- 98549-88-3
- Chemical Name
- 1H-PYRROLO[2,3-B]PYRIDIN-5-OL
- Synonyms
- 5-HYDROXY-7-AZAINDOLE;SW-63;SWF-63;5-Hydroxyazaindole;Vinetola impurity 12;5-Hydroxy-7-azaindole 97%;H-PYRROLO[2,3-B]PYRIDIN-5-OL;1H-Pyrrolo[2,3-B]Pridin-5-ol;1H-PYRROLO[2,3-B]PYRIDIN-5-OL;5-hydroxypyrrolo[2,3-b]pyridine
- CBNumber
- CB3484584
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 98549-88-3.mol
1H-PYRROLO[2,3-B]PYRIDIN-5-OL Property
- Melting point:
- 219-220°C
- Boiling point:
- 381.8±42.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Powder
- pka
- 6.93±0.20(Predicted)
- Appearance
- Light brown to light yellow Solid
- InChI
- InChI=1S/C7H6N2O/c10-6-3-5-1-2-8-7(5)9-4-6/h1-4,10H,(H,8,9)
- InChIKey
- VUQZKLXKFUBWRP-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC(O)=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000886
- Product name
- 1H-Pyrrolo[2,3-b]pyridin-5-ol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- P998405
- Product name
- 1H-Pyrrolo[2,3-b]pyridin-5-ol
- Packaging
- 2.5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- CS-D0720
- Product name
- 1H-Pyrrolo[2,3-b]pyridin-5-ol
- Purity
- 98.12%
- Packaging
- 25g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- JK601917
- Product name
- 5-Hydroxy-7-azaindole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $219
- Updated
- 2021/12/16
- Product number
- 023733
- Product name
- 1H-Pyrrolo[2,3-b]pyridin-5-ol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $247
- Updated
- 2021/12/16
1H-PYRROLO[2,3-B]PYRIDIN-5-OL Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
1H-?Pyrrolo[2,?3-?b]?pyridin-?5-?ol is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets.
Synthesis
858116-66-2
98549-88-3
General procedure for the synthesis of 1H-pyrrolo[2,3-b]pyridin-5-ol from 1-triisopropylsilyl-5-bromo-7-azaindole: To a 50 mL reaction flask at room temperature were added the compound of formula II (4.08 g, 11.5 mmol), copper acetylacetonate (0.15 g, 0.575 mmol), MHPO (0.15 g, 0.575 mmol), lithium hydroxide monohydrate (2.42 g, 57.5 mmol), 18 mL of DMSO, and 4.5 mL of water. Stirring was turned on, the air in the reaction system was replaced with nitrogen, and the reaction temperature was raised to an internal temperature of 100°C. The reaction was maintained at this temperature for 6 h. The reaction was carried out by TLC. The progress of the reaction was monitored by TLC and after confirming that the ingredients were fully reacted, the heating was stopped and the reaction mixture was cooled to room temperature (20-30°C). 100 mL of water was added to the reaction mixture and the pH was adjusted to 6 with 2 N dilute hydrochloric acid, at which point a solid precipitated. Filtering was carried out and the solid was collected. The aqueous phase was extracted with ethyl acetate (50 mL × 3) and the organic phases were combined. The organic phase was washed sequentially with water and saturated aqueous sodium chloride solution each, and then dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give the compound of formula III. Yield: 1.2 g, yield: 78.5%.
References
[1] Patent: CN107434807, 2017, A. Location in patent: Paragraph 0056-0059; 0080-0083; 0102-0106
1H-PYRROLO[2,3-B]PYRIDIN-5-OL Preparation Products And Raw materials
Raw materials
Preparation Products
1H-PYRROLO[2,3-B]PYRIDIN-5-OL Suppliers
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- Europe
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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDIN-5-OL manufacturers
- Product
- 5-Hydroxy-7-azaindole 98549-88-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 1H-Pyrrolo[2,3-b]pyridin-5-ol 98549-88-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-13
- Product
- Venetoclax Impurity 12 98549-88-3
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-03-28