ChemicalBook > CAS DataBase List > 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

Product Name: 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CAS No.: 2305369-00-8
Chemical Name: 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
Synonyms: Poma-C2-NH2·HCl;Pomalidomide-C2-NH2 HCl;Thalidomide-NH-C2-NH2.HCl;Thalidomide-4-NH-C2-NH2 HCl;Pomalidomide 4'-alkylC2-amine;Pomalidomide-C2-NH2 hydrochloride;E3 ligase Ligand 17 hydrochloride;Cereblon Ligand-Linker Conjugates 15 (hydrochloride);Pomalidomide-C₂-NH₂ hydrochloride;4-(2-aminoethylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CBNumber: CB35513434
Molecular Formula: C15H17ClN4O4
Formula Weight: 352.78
MOL File: 2305369-00-8.mol

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1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Property

storage temp.: 2-8°C
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H
InChIKey: DSJCOXQYDMWPEY-UHFFFAOYSA-N
SMILES: O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC(NCCN)=C12.Cl

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

CSNpharm

Product number: CSN23971
Product name: Pomalidomide-C2-Amine
Packaging: 5mg
Price: $326
Updated: 2021/12/16

DC Chemicals

Product number: DC26122
Product name: Pomalidomide-C2-NH2hydrochloride
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC26122
Product name: Pomalidomide-C2-NH2hydrochloride
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties,Usage,Production

Uses

Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

Biological Activity

Pomalidomide 4'-alkylC2-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC2 linker with terminal amine ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 7

IC 50

Cereblon

storage

Store at -20°C

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-C2-NH2 hydrochloride 2305369-00-8
Price: US $0.00/g
Min. Order: 1g
Purity: >96.00%
Supply Ability: 1g
Release date: 2024-04-01

2305369-00-8, 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)Related Search:

E3 ligase Ligand-Linker Conjugates 49 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 4-((4-azidobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione -alkylC5-amine

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

Pomalidomide-C2-NH2 hydrochloride

Cereblon Ligand-Linker Conjugates 15 (hydrochloride)

4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl )-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride

E3 ligase Ligand 17 hydrochloride

4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

4-(2-aminoethylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione

Thalidomide-NH-C2-NH2.HCl

PomalidomideC2NH2 hydrochloride,inhibit,Inhibitor,Pomalidomide-C-2-NH2 hydrochloride,E3 Ligase Ligand-Linker Conjugates,Pomalidomide C2 NH2 hydrochloride,Cereblon Ligand-Linker Conjugates 15

4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17

Poma-C2-NH2·HCl

Thalidomide-4-NH-C2-NH2 HCl

4-(2-aminoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Pomalidomide 4'-alkylC2-amine

Pomalidomide-C<sub>2</sub>-NH<sub>2</sub> hydrochloride

4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Hydrochloride

Pomalidomide-C2-NH2 HCl

2305369-00-8

C15H16N4O4ClH