ChemicalBook > CAS DataBase List > BOC-SER-OH

BOC-SER-OH

Product Name: BOC-SER-OH
CAS No.: 59524-02-6
Chemical Name: BOC-SER-OH
Synonyms: BOC-L-SER;BOC-SERINE;BOC-SER-OH;BOC-L-SER-OH;BOC-SER-OBZL;Boc-L-Serine;BOC-SERINE-OH;N-BOC-L-SERINE;BOC-L-SER-OBZL;BOC-SERINE-OBZL
CBNumber: CB3668034
Molecular Formula: C15H21NO5
Formula Weight: 295.33
MOL File: 59524-02-6.mol

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BOC-SER-OH Property

Melting point:: 91 °C (dec.)(lit.)
Boiling point:: 458.8±40.0 °C(Predicted)
Density: 1.174±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka: 10.67±0.46(Predicted)
form: Powder
color: White
Water Solubility: Slightly soluble in water.
InChIKey: BQADRZHPZVQGCW-LBPRGKRZSA-N
CAS DataBase Reference: 59524-02-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
F: 10
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B673138
Product name: Boc-Ser-OBzl
Packaging: 25g
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 265097
Product name: Boc-L-serine benzyl ester
Packaging: 5g
Price: $369
Updated: 2021/12/16

AK Scientific

Product number: J93084
Product name: Boc-Ser-OBzl
Packaging: 1g
Price: $10
Updated: 2021/12/16

Oakwood

Product number: M03322
Product name: Boc-Ser-OBzl
Packaging: 1g
Price: $10
Updated: 2021/12/16

Chem-Impex

Product number: 05600
Product name: Boc-L-serinebenzylester,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $11.2
Updated: 2021/12/16

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BOC-SER-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

It is a pharmaceutical intermediate. It is involved in Mitsunobu Reactions.

Synthesis

3262-72-4

100-39-0

59524-02-6

GENERAL STEPS: To a stirred solution of N-Boc-L-serine (4.87 mmol) in DMF (100 mL) was added cesium carbonate (5.11 mmol) and stirring was continued for 30 minutes. Benzyl bromide (5.84 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (25 mL) and washed sequentially with aqueous lithium bromide (3 × 15 mL), aqueous sodium bicarbonate (2 × 15 mL) and saturated saline (2 × 15 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to afford Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1). To a stirred solution of N-Boc-L-serine (2.44 mmol) in DMF (50 mL) was added cesium carbonate (2.56 mmol) and stirring was continued for 30 min. Benzyl bromide (2.92 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (15 mL) and washed sequentially with aqueous lithium bromide (3 × 10 mL), aqueous sodium bicarbonate (2 × 10 mL) and saturated saline (2 × 10 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to give Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3401 - 3404
[2] Patent: WO2005/41899, 2005, A2. Location in patent: Page/Page column 94; 102-103
[3] Patent: WO2005/41899, 2005, A2. Location in patent: Page/Page column 94; 102-103
[4] Journal of the American Chemical Society, 2012, vol. 134, # 45, p. 18809 - 18815
[5] Patent: US2017/158720, 2017, A1. Location in patent: Paragraph 0114; 0115; 0171; 0172

BOC-SER-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-SER-OH manufacturers

Career Henan Chemical Co

Product: BOC-SER-OH 59524-02-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-19

59524-02-6, BOC-SER-OHRelated Search:

BOC-TRP-OME Boc-L-Threonine BOC-L-Tyrosine L-Serine BOC-SER-OH BOC-SER-OH,Boc-Ser-OH Synonyms:Boc-L-serine BOC-ALA-OBZL BOC-SER-OH H2O,BOC-SER-OH MONOHYDRATE N-BOC-SERINOL, 97 Boc-L-serine methyl ester N-Boc-(S)-2-amino-3-benzyloxy-1-propanol TERT-BUTOXYCARBONYLAMINO-ACETIC ACID BENZYL ESTER TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-SER(TOS)-OBZL N-FMOC-(S)-2-AMINO-3-T-BUTOXY-1-PROPANOL BOC-L-SER(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC--SER-OH H20

BOC-L-SER

BOC-L-SER-OH

BOC-L-SER-OBZL

BOC-SER-OH

BOC-SER-OBZL

BOC-SERINE-OH

BOC-SERINE

BOC-SERINE-OBZL

N-T-BUTOXYCARBONYL-L-SERINE

N-BOC-L-SERINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-SERINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-SERINE BENZYL ESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-SERINE BENZYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-SERINE ALPHA-BENZYL ESTER

N-ALPHA-T-BOC-L-SERINE

N-tert-Butoxycarbonyl-L-serine benzyl ester

Benzyl (2S)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoate

(S)-2-(tert-Butoxycarbonylamino)-3-hydroxypropanoic acid

Boc-L-Serine

(S)-benzyl 2-(tert-butoxycarbonylamino)-3-hydroxypropanoate

(S)-2-(tert-Butoxycarbonylamino)-3-hydroxypropanoic acid benzyl ester

N-Boc-L-serine benzyl ester, 95%

BOC-L-SERINE BENZYL ESTER

(S)-Boc-2-amino-3-hydroxypropionic acid benzyl ester

Boc-L-b-hydroxyalanine benzyl ester

Boc-L-serine benzyl ester≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl Ser-OBzl

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester

benzyl (2S)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

N-[(1,1-Dimethylethoxy)carbonyl]-L-serine phenylmethyl ester

59524-02-6

58524-02-6

59524-02-

Peptide Synthesis

Serine

Specialty Synthesis

Amino Acids (N-Protected)

Protected & Labeled Amino Acids

Boc-Amino Acids

Amino Acid Derivatives

Serine [Ser, S]

Boc-Amino Acids and Derivative

Boc-Amino acid series