BOC-SER-OH
- Product Name
- BOC-SER-OH
- CAS No.
- 59524-02-6
- Chemical Name
- BOC-SER-OH
- Synonyms
- BOC-L-SER;BOC-SERINE;BOC-SER-OH;BOC-L-SER-OH;BOC-SER-OBZL;Boc-L-Serine;BOC-SERINE-OH;N-BOC-L-SERINE;BOC-L-SER-OBZL;BOC-SERINE-OBZL
- CBNumber
- CB3668034
- Molecular Formula
- C15H21NO5
- Formula Weight
- 295.33
- MOL File
- 59524-02-6.mol
BOC-SER-OH Property
- Melting point:
- 91 °C (dec.)(lit.)
- Boiling point:
- 458.8±40.0 °C(Predicted)
- Density
- 1.174±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 10.67±0.46(Predicted)
- form
- Powder
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChIKey
- BQADRZHPZVQGCW-LBPRGKRZSA-N
- CAS DataBase Reference
- 59524-02-6(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- F
- 10
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B673138
- Product name
- Boc-Ser-OBzl
- Packaging
- 25g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 265097
- Product name
- Boc-L-serine benzyl ester
- Packaging
- 5g
- Price
- $369
- Updated
- 2021/12/16
- Product number
- J93084
- Product name
- Boc-Ser-OBzl
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- M03322
- Product name
- Boc-Ser-OBzl
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 05600
- Product name
- Boc-L-serinebenzylester,99%(HPLC)
- Purity
- 99%(HPLC)
- Packaging
- 1G
- Price
- $11.2
- Updated
- 2021/12/16
BOC-SER-OH Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
It is a pharmaceutical intermediate. It is involved in Mitsunobu Reactions.
Synthesis
3262-72-4
100-39-0
59524-02-6
GENERAL STEPS: To a stirred solution of N-Boc-L-serine (4.87 mmol) in DMF (100 mL) was added cesium carbonate (5.11 mmol) and stirring was continued for 30 minutes. Benzyl bromide (5.84 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (25 mL) and washed sequentially with aqueous lithium bromide (3 × 15 mL), aqueous sodium bicarbonate (2 × 15 mL) and saturated saline (2 × 15 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to afford Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1). To a stirred solution of N-Boc-L-serine (2.44 mmol) in DMF (50 mL) was added cesium carbonate (2.56 mmol) and stirring was continued for 30 min. Benzyl bromide (2.92 mmol) was then added and the reaction mixture was stirred for 12 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (15 mL) and washed sequentially with aqueous lithium bromide (3 × 10 mL), aqueous sodium bicarbonate (2 × 10 mL) and saturated saline (2 × 10 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent: petroleum ether/ether = 1:1) to give Boc-L-serine benzyl ester (100% yield) as a white solid. rf = 0.26 (petroleum ether/ether = 1:1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3401 - 3404
[2] Patent: WO2005/41899, 2005, A2. Location in patent: Page/Page column 94; 102-103
[3] Patent: WO2005/41899, 2005, A2. Location in patent: Page/Page column 94; 102-103
[4] Journal of the American Chemical Society, 2012, vol. 134, # 45, p. 18809 - 18815
[5] Patent: US2017/158720, 2017, A1. Location in patent: Paragraph 0114; 0115; 0171; 0172
BOC-SER-OH Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-SER-OH Suppliers
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- Country
- Germany
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- info@abcr.de
- Country
- Germany
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View Lastest Price from BOC-SER-OH manufacturers
- Product
- BOC-SER-OH 59524-02-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-19