Neostigmine bromide

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Neostigmine bromide

Product Name: Neostigmine bromide
CAS No.: 114-80-7
Chemical Name: Neostigmine bromide
Synonyms: Prostigmi;Neostigmin;Neoesserin;prostigmin;Neoserine);Juvastigmin;PROSTIGMINE;stigmosanbromide;stigmanolbromide;eustigminbromide
CBNumber: CB3677212
Molecular Formula: C12H19BrN2O2
Formula Weight: 303.2
MOL File: 114-80-7.mol

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Neostigmine bromide Property

Melting point:: 175-177 °C(lit.)
Density: 1.4344 (rough estimate)
refractive index: 1.5410 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: H₂O: 1 g/mL
form: powder
color: white
PH: 5.2～6.2 (100g/l, 25℃)
Water Solubility: 1 g/ mL
Merck: 14,6464
BCS Class: 3
EPA Substance Registry System: Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (114-80-7)

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Safety

Hazard Codes: T+,T
Risk Statements: 26/27/28-36/37/38-42/43-25
Safety Statements: 22-26-36/37/39-45-37/39-28A
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: BR3150000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29239000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2001
Product name: Neostigmine bromide
Purity: ≥98% (HPLC and titration), powder
Packaging: 1g
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1459001
Product name: Neostigmine bromide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $250
Updated: 2024/03/01

TCI Chemical

Product number: N0358
Product name: Neostigmine Bromide
Purity: >99.0%(T)
Packaging: 5g
Price: $90
Updated: 2024/03/01

TCI Chemical

Product number: N0358
Product name: Neostigmine Bromide
Purity: >99.0%(T)
Packaging: 25g
Price: $294
Updated: 2024/03/01

Alfa Aesar

Product number: J62300
Product name: Neostigmine bromide
Packaging: 250mg
Price: $47.65
Updated: 2024/03/01

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Neostigmine bromide Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

antiscorbutic, antiviral

Uses

Cholinergic; miotic; antidote (curare)

Uses

A reversible acetylcholinesterase inhibitor

Uses

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
to study its effects on depolarization of bag cell neurons.

Definition

ChEBI: Neostigmine bromide is the bromide salt of neostigmine. It contains a neostigmine.

General Description

Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.

Biological Activity

neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]ache (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. it terminates the signal transductions and plays a role in neuronal apoptosis.neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. it is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. it is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]

Biochem/physiol Actions

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

Clinical Use

Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.

Purification Methods

Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).

References

[1] el-kosasy am, nebsen m, abd el-rahman mk, salem my, el-bardicy mg. comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. talanta. 2011 aug 15;85(2):913-8.

Neostigmine bromide Preparation Products And Raw materials

Raw materials

Dimethylcarbamoyl chloride Methyl bromide

Preparation Products

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View Lastest Price from Neostigmine bromide manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Neostigmine bromide 114-80-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-07-13

Hebei Mojin Biotechnology Co., Ltd

Product: Neostigmine bromide 114-80-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-06

Hebei Guanlang Biotechnology Co., Ltd.

Product: Neostigmine bromide 114-80-7
Price: US $10.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-03-11

114-80-7, Neostigmine bromide Related Search:

Ammonium sulfate Ethidium bromide 4-Dimethylaminobenzoic acid Dimidium bromide 4-Dimethylaminobenzaldehyde Dimethyldimethoxysilane Ammonium acetate 4-Dimethylaminopyridine Trimethyl borate Ammonium hydroxide 1,1-Dimethoxyethane Rocuronium bromide Vecuronium bromide Allyl bromide Sodium bromate Ammonium chloride Molybdic acid Neostigmine Impurity 1

stigmanolbromide

stigmosanbromide

synstigminbromide

(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE

3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE

3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE

(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE

Juvastigmin

Neoesserin

Neostigmin

Prostigmi

3-(n,n-dimethylcarbamoyloxy)-n,n,n,-trimethylanilinium bromide

NEOSTIGMINEBROMIDE,USP

NEOSTIGMINE BROMIDE(RG)

synthostigminebromide

syntostigmin(tablet)

syntostigminbromide

syntostigminebromide

vagostigminebromide

NEOSTIGMINE BROMIDE IRREVERSIBLE INHIBIT O

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine

prostigmin

PROSTIGMINE

NEOSTIGIMINE BROMIDE

NEOSTIGMINE BROMIDE

(m-hydroxyphenyl)trimethyl-ammonium bromide dimethylcarbamate

3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiubromide

3-[[Dmiethylamino)carbonyl]oxy]-N,N,N-trimethylbenzen-aminium

3-dimethylcarbamoxyphenyltrimethylammoniumbromide

3-hydroxyphenyltrimethylammoniumbromidedimethylcarbamicester

Ammonium,(m-hydroxyphenyl)trimethyl-,bromide,dimethylcarbamate

Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-,bromide(9CI)

dimethyl-carbamicaciesterwith(m-hydroxyphenyl)trimethylammoniumbromi

eustigminbromide

kirkstigminebromide

leostigminebromide

neoserinebromide

neostigminemethylbromide

philostigminbromide

proserinebromide

prostigminbromide

prostigminebromide

rcrawastenumberu053

Synstigmine bromide

Neostigmine bromide,99%

Neostigmine Bromide (200 mg)

3-[(diMethylcarbaMoyl)oxy]-N,N,N-triMethylaniliniuM broMide

NeostigMine broMide(ProstigMin)

Neoeserine BroMide

(3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate

3-((diMethylcarbaMoyl)oxy)-N,N,N-triMethylbenzenaMiniuM broMide

3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-benzenaminium,bromide (1:1)

Neostigmine bromide, 98%, a reversible acetylcholinesterase inhibitor

Neostigmine BromideChemical Structure

NeostigmineBromide&gt

Neostigmine bromide CRS

NeostigminiBromidum

Neostigmine bromide USP/EP/BP