Carbenoxolone disodium

Product Name: Carbenoxolone disodium
CAS No.: 7421-40-1
Chemical Name: Carbenoxolone disodium
Synonyms: neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
CBNumber: CB3680281
Molecular Formula: C34H48Na2O7
Formula Weight: 614.72
MOL File: 7421-40-1.mol

More

Less

Carbenoxolone disodium Property

Melting point:: >275°C (dec.)
storage temp.: 2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: pKa1 4.18; pKa2 5.52(at 25℃)
color: White to Off-White
Water Solubility: Soluble in water to 100 mM.
Stability:: Hygroscopic
LogP: 7.083 (est)
CAS DataBase Reference: 7421-40-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26-36
WGK Germany: 3
RTECS: RK0250000
Toxicity: LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C4790
Product name: Carbenoxolone disodium salt
Purity: ≥98%
Packaging: 1g
Price: $56
Updated: 2025/07/31

Sigma-Aldrich

Product number: C4790
Product name: Carbenoxolone disodium salt
Purity: ≥98%
Packaging: 5g
Price: $233
Updated: 2025/07/31

Cayman Chemical

Product number: 18240
Product name: Carbenoxolone (sodium salt)
Purity: ≥98%
Packaging: 1g
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 18240
Product name: Carbenoxolone (sodium salt)
Purity: ≥98%
Packaging: 5g
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 18240
Product name: Carbenoxolone (sodium salt)
Purity: ≥98%
Packaging: 10g
Price: $279
Updated: 2024/03/01

More

Less

Carbenoxolone disodium Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Biogastrone,Winthrop,UK,1963

Uses

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.

Uses

Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative

Uses

beta-adrenergic agonist, growth stimulant

Definition

ChEBI: Carbenoxolone sodium is a triterpenoid.

Manufacturing Process

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.

Therapeutic Function

Antiinflammatory (gastric)

General Description

Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.

Biological Activity

Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.

storage

Store at +4°C

References

[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.

Carbenoxolone disodium Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Carbenoxolone disodium Suppliers

Canada 1 China 112 Europe 2 Germany 1 India 1 Switzerland 1 United Kingdom 5 United States 25 USA 1 Global 149

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19961
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

Altan Corporation

Tel: --
Fax: --
Email: OrderingService@AltanBiochemicals.com
Country: United States
ProdList: 1161
Advantage: 30

Abcam Limited

Tel: --
Fax: --
Email: us.orders@abcam.com
Country: United States
ProdList: 6001
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Spectrum Chemical Mfg. Corp.

Tel: --
Fax: --
Email: marketing@spectrumchemical.com
Country: United States
ProdList: 3113
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

More

Less

View Lastest Price from Carbenoxolone disodium manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Carbenoxolone disodium 7421-40-1
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

Career Henan Chemical Co

Product: Carbenoxolone disodium 7421-40-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

7421-40-1, Carbenoxolone disodiumRelated Search:

Sodium chlorite Sodium formate Sodium salicylate Ethylenediaminetetraacetic acid disodium salt Sodium gluconate Trisodium citrate dihydrate Sodium carbonate Sodium silicate Sodium percarbonate Sodium benzoate 18β-Glycyrrhetinic Acid Sodium Monofluorophosphate Carbenoxolone SODIUM CYCLOHEXANEBUTYRATE LAURIC ACID SODIUM SALT Sodium cyclohexanecarboxylate 3-Methyl-5-ethyl-2-cyclohexen-1-one SODIUM 4-HYDROXYBUTYRATE

(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT

CARBENOXOLONE DISODIUM SALT

CARBENOXOLONE SODIUM

18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt

20-beta)-3-bet

3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal

3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium

disodiumglycyrrhetinylsuccina

duogastrone

glycyrrhetinicacidhydrogensuccinate,disodiumsalt

neogel

olean-12-en-29-oicacid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,disodiumsalt,(

olean-12-en-30-oicacid,3-beta-hydroxy-11-oxo-,hydrogensuccinate,disodiums

pyrogastrone

sanodin

sodium3-beta-hydroxy-11-oxo-12-oleanen-30-oatesodiumsuccinate

sodiumcarbenoxolone

ulcus-tablinen

3β-hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate

Carbenoxolone sodium [USAN:JAN]

(3,20)-3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic Acid

3-Hydroxy-11-oxoolean-12-en-30-oic Acid Hydrogen Succinate Disodium Salt

Carbenoxalone Sodium

carbenoxolone disodium

disodium 4-(20-carboxylato-11-oxo-30-beta-norolean-12-en-3-yloxy)-4-oxobutyrate

(20S)-3β-[(3-Carboxypropanoyl)oxy]-11-oxoolean-12-en-29-oic acid disodium salt

18β-Glycyrrhetinic acid hydrogen succinate disodium salt

3β-(3-Carboxypropionyloxy)-11-oxoolean-12-en-30-oic acid disodium salt

(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium

Carbenoxolone disodiuM salt >=98%

Disodium (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-(4-oxido-4-oxobutanoyl)oxy-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate

Carbenoxolone (sodium salt)

Carbenoxolone disodium (YP 003 disodium)

DISODIUM 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID

Carbenoxolone disodium USP/EP/BP

Carbenoxolone disodi

Carbenoxolonedisodium,(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxypropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid, sodium salt

Sodium (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxylatopropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate

Carbenoxolone disodium salt, Panx1 hemichannel inhibitor

Carbenoxolone disodium, 10 mM in DMSO

7421-40-1

C34H48Na2O7

Complex Molecules

Asymmetric Synthesis

Chiral Building Blocks

OPTAFLEXX

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids

Miscellaneous