2-Piperidone

Product Name: 2-Piperidone
CAS No.: 675-20-7
Chemical Name: 2-Piperidone
Synonyms: piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
CBNumber: CB3680771
Molecular Formula: C5H9NO
Formula Weight: 99.13
MOL File: 675-20-7.mol

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2-Piperidone Property

Melting point:: 38-40 °C (lit.)
Boiling point:: 256 °C (lit.) 81-82 °C/0.1 mmHg (lit.)
Density: 1.073
refractive index: 1.4431 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Low Melting Crystalline Mass
color: White to yellow to brown
PH: 4.8 (200g/l, H2O, 20℃)
explosive limit: 1.5-8.7%(V)
Water Solubility: 291 g/L (25 ºC)
Sensitive: Hygroscopic
BRN: 106434
Stability:: Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey: XUWHAWMETYGRKB-UHFFFAOYSA-N
CAS DataBase Reference: 675-20-7(CAS DataBase Reference)
NIST Chemistry Reference: 2-Piperidinone(675-20-7)
EPA Substance Registry System: 2-Piperidone (675-20-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37-36/37/38
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
RTECS: TO0110000
F: 3-10
TSCA: Yes
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V209
Product name: δ-Valerolactam
Purity: 98%
Packaging: 25g
Price: $80.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: V209
Product name: δ-Valerolactam
Purity: 98%
Packaging: 100g
Price: $212
Updated: 2024/03/01

TCI Chemical

Product number: P0455
Product name: 2-Piperidone
Purity: >98.0%(GC)
Packaging: 25g
Price: $68
Updated: 2024/03/01

TCI Chemical

Product number: P0455
Product name: 2-Piperidone
Purity: >98.0%(GC)
Packaging: 100g
Price: $184
Updated: 2024/03/01

Alfa Aesar

Product number: A12271
Product name: delta-Valerolactam, 98%
Packaging: 25g
Price: $60.65
Updated: 2024/03/01

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2-Piperidone Chemical Properties,Usage,Production

Chemical Properties

white to yellowish low melting crystalline mass

Uses

δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.

Definition

ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.

Preparation

2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 7629, 1980 DOI: 10.1021/ja00546a001
Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI: 10.1021/jo01115a010

Purification Methods

Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]

2-Piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperidone Suppliers

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View Lastest Price from 2-Piperidone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Piperidone 675-20-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Wuhan Boyuan Import & Export Co., LTD

Product: 2-Piperidone 675-20-7
Price: US $23.00-18.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000tons
Release date: 2024-04-07

Shandong Juchuang Chemical Co., LTD

Product: 2-Piperidone 675-20-7
Price: US $65.00-45.00/kg
Min. Order: 500kg
Purity: 99.9
Supply Ability: 200tons
Release date: 2024-03-08

675-20-7, 2-PiperidoneRelated Search:

N-Methyl-2-pyrrolidone Cyclohexanone Laurocapram Cyclopentanone Buspirone TRIAMYLAMINE Propyzamide Amylamine Diltiazem hydrochloride 1,5-Diaminopentane 2',6'-Pipecoloxylidide 3,5-Diiodo-L-tyrosine dihydrate 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine Piperidine Chlorophacinone 3-CARBETHOXY-2-PIPERIDONE 3,3-Tetramethyleneglutarimide

2-Piperidinone for synthesis

2-KETOPIPERIDINE

2-AZACYCLOHEXANONE

5-pentanelactam

5-Pentanolactam

Pentanoic acid, 5-amino-, lactam

Piperidon

Piperidone-2

valerolactim

delta-Valerolactame

delta-Valerolactam,97%

i-valerolactam

3,4,5,6-Tetrahydropyridine-2-ol

5-Aminovaleric acid lactam

^d-Valerolactam, 98+%

delta-Valerolactam,99%

δ-Valerolactam, 98+%

Left Bupivacaine Impurity 10

VALEROLACTAM

piperidin-2-one

D-VALEROLACTAM

DELTA-VALEROLACTAM

ALPHA-PIPERIDONE

6-VALEROLACTAM

2-PIPERIDONE

2-PIPERIDINONE

2-Piperidone ,98.5%

2-Oxo-piperidine

delta-Valerolactam, 2-Azacyclohexan-1-one

Piperidin-5-one

Piperidin-6-one

Piperidin-7-one

delta-ValerolactaM, 99% 100GR

delta-ValerolactaM, 99% 25GR

delta-ValerolactaM, 99% 5GR

2-Azacyclohexanone delta-Valerolactam

2-Piperidone Synonyms Piperidin-2-one

δ-Valerolactam, >=99%

delta-Valerolactam, 98+%

delta-ValerolactaM 98%

2-Piperidone, 97+%

3-CHLORO-2-(HYDROX...

2-Piperidone&gt

Bupivacaine Impurity 26

2-PIPERIDONE 675-20-7

RSSYY(Perospirone Hydrochloride Hydrate)-14

RSSYY(Perospirone Hydrochloride Hydrate)-11

2-Piperidone (8CI)

Piperidone impurity 2（Bupivacaine Impurity7）

Valarolactam

Meso-2,4-Dichloropentane

2-Piperidone, Valerolactam, 2-Azacyclohexanone, 2-Ketopiperidine, 2-Piperidinone, 2-Piperidone, 6-Valerolactam, Alpha-Piperidone, Delta-Valerolactam, D-Valerolactam, Piperidin-2-one, Valerolactam, 5-Pentanelactam, 5-Pentanolactam, Pentanoic acid, 5-amino-, lactam, Piperidon, Piperidone-2, valerolactim, delta-Valerolactame, delta-Valerolactam, i-valerolactam

675-20-7

675-20-8

675-20-9

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