4-Methylphenylacetic acid
- Product Name
- 4-Methylphenylacetic acid
- CAS No.
- 622-47-9
- Chemical Name
- 4-Methylphenylacetic acid
- Synonyms
- P-TOLYLACETIC ACID;2-p-Tolylacetic acid;Tolylacetic acid;p-Tolylacetic;ASISCHEM D13361;p-Tolylessigsure;p-Tolyacetic acid;4-TOLYLACETIC ACID;RARECHEM AL BO 0137;(p-tolyl)-aceticaci
- CBNumber
- CB3695209
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 622-47-9.mol
4-Methylphenylacetic acid Property
- Melting point:
- 88-92 °C (lit.)
- Boiling point:
- 265-267 °C (lit.)
- Density
- 1.0858 (rough estimate)
- refractive index
- 1.5002 (estimate)
- Flash point:
- 265-267°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- pK1:4.370 (25°C)
- form
- Fine Crystalline Powder
- color
- White
- BRN
- 2043528
- InChI
- InChI=1S/C9H10O2/c1-7-2-4-8(5-3-7)6-9(10)11/h2-5H,6H2,1H3,(H,10,11)
- InChIKey
- GXXXUZIRGXYDFP-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(C)C=C1
- CAS DataBase Reference
- 622-47-9(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Tolylacetic acid(622-47-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- RTECS
- AJ7569000
- HazardClass
- IRRITANT
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T38105
- Product name
- p-Tolylacetic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 25g
- Price
- $460
- Updated
- 2025/07/31
- Product number
- T38105
- Product name
- p-Tolylacetic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 5g
- Price
- $90.2
- Updated
- 2023/06/20
- Product number
- T0882
- Product name
- p-Tolylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- T0882
- Product name
- p-Tolylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $279
- Updated
- 2025/07/31
- Product number
- T536575
- Product name
- p-Tolylacetic acid
- Packaging
- 25g
- Price
- $635
- Updated
- 2021/12/16
4-Methylphenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
white fine crystalline powder
Uses
p-Tolylacetic acid is a reagent used in the preparation of quaternary amines and epithelial sodium channel inhibition in bronchial epithelium.
Application
4-Methylphenylacetic acid is mainly used as a key starting material or reagent for the synthesis of various complex compounds, such as for the preparation of quaternary ammonium salts, and as a precursor for the synthesis of pesticides and pharmaceutical intermediates (such as 4-bromomethylphenylacetic acid and 4-hydroxymethylphenylacetic acid). It is also used in the research of bronchial epithelial sodium channel inhibitors.
Preparation
The main method for preparing 4-methylphenylacetic acid is through the hydrolysis of 4-methylphenylacetonitrile (p-tolueneacetonitrile). This method involves hydrolyzing 4-methylphenylacetonitrile under acidic or alkaline conditions to generate the corresponding carboxylic acid. This method is relatively simple to operate and easy to scale up for industrial production.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 1919, 1983 DOI: 10.1021/jo00159a031
Tetrahedron Letters, 28, p. 2633, 1987 DOI: 10.1016/S0040-4039(00)96167-7
Purification Methods
Crystallise the acid from heptane or water. [Beilstein 9 IV 1795.]
4-Methylphenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Methylphenylacetic acid manufacturers
- Product
- 4-Methylphenylacetic acid 622-47-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- 4-Methylphenylacetic acid 622-47-9
- Price
- US $1000.00/KG
- Min. Order
- 0.1KG
- Purity
- 98%HPLC
- Supply Ability
- 2tons
- Release date
- 2025-08-15
- Product
- 4-Methylphenylacetic acid 622-47-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-15