ChemicalBook > CAS DataBase List > Sieber Linker

Sieber Linker

Product Name
Sieber Linker
CAS No.
3722-51-8
Chemical Name
Sieber Linker
Synonyms
HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
CBNumber
CB3710805
Molecular Formula
C13H8O3
Formula Weight
212.2
MOL File
3722-51-8.mol
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Sieber Linker Property

Melting point:
243 °C
Boiling point:
403.9±24.0 °C(Predicted)
Density 
1.395±0.06 g/cm3(Predicted)
storage temp. 
Store at 0°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
7.52±0.20(Predicted)
form 
Solid
color 
White to Orange to Green
InChI
InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
InChIKey
XCJHDJAODLKGLG-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
CAS DataBase Reference
3722-51-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29329900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1269
Product name
3-Hydroxyxanthen-9-one
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
H1269
Product name
3-Hydroxyxanthen-9-one
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$107
Updated
2024/03/01
Alfa Aesar
Product number
H63495
Product name
3-Hydroxyxanthone, 98%
Packaging
1g
Price
$49
Updated
2022/04/27
Alfa Aesar
Product number
H63495
Product name
3-Hydroxyxanthone, 98%
Packaging
5g
Price
$191
Updated
2022/04/27
TRC
Product number
S699028
Product name
SieberLinker
Packaging
50mg
Price
$45
Updated
2021/12/16
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Sieber Linker Chemical Properties,Usage,Production

Chemical Properties

White to off-white or grey powder

Uses

Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.

Synthesis Reference(s)

Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6

Purification Methods

Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]

Sieber Linker Preparation Products And Raw materials

Raw materials

Pyridine hydrochloride o-Anisoyl chloride Salicylic acid o-Anisic acid Phosphoric acid 1,3-Dimethoxybenzene Zinc chloride Phosphorus oxychloride Resorcinol Hydrochloric acid Phosphorus pentoxide

Preparation Products

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Sieber Linker Suppliers

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View Lastest Price from Sieber Linker manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Sieber Linker 3722-51-8
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-11
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Sieber Linker 3722-51-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-04-15
Suzhou Eebetter Biotechnology Co., Ltd.
Product
SieberLinker 3722-51-8
Price
US $70344.80-5944827.00/kg
Min. Order
100kg
Purity
99%
Supply Ability
10 tons
Release date
2023-08-30

3722-51-8, Sieber LinkerRelated Search:

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  • SIEBER LINKER
  • SALOR-INT L254835-1EA
  • HF
  • 6-HYDROXY-3-FLUORONE
  • 3-HYDROXY-XANTHEN-9-ONE
  • 3-HYDROXYXANTHONE
  • 3-Hydroxy-9H-xanthen-9-one
  • SIEBER LINKER,3-HYDROXY-XANTHEN-9-ONE
  • 3-HYDROXY-XANTHEN-9-ONE SIEBER LINKER 99+%
  • SIEBER LINKER, 99% MIN.
  • 3-hydroxy-9H-9-xanthenone
  • 3-Hydroxy-9H-xanthen-9-one ,97%
  • Sieber linker≥ 99% (HPLC)
  • 3-Hydroxyxanthen-9-one&gt
  • 9H-Xanthen-9-one, 3-hydroxy-
  • Sieber Linker (3-Hydroxyxanthone) extrapure, 99%
  • Sibur linker
  • 3722-51-8
  • Linkers for Solid Phase Synthesis
  • Linkers for solid phase synthesis
  • linker