ChemicalBook > CAS DataBase List > Sieber Linker
Sieber Linker
- Product Name
- Sieber Linker
- CAS No.
- 3722-51-8
- Chemical Name
- Sieber Linker
- Synonyms
- HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
- CBNumber
- CB3710805
- Molecular Formula
- C13H8O3
- Formula Weight
- 212.2
- MOL File
- 3722-51-8.mol
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Sieber Linker Property
- Melting point:
- 243 °C
- Boiling point:
- 403.9±24.0 °C(Predicted)
- Density
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 7.52±0.20(Predicted)
- form
- Solid
- color
- White to Orange to Green
- InChI
- InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
- InChIKey
- XCJHDJAODLKGLG-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
- CAS DataBase Reference
- 3722-51-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- H1269
- Product name
- 3-Hydroxyxanthen-9-one
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $35
- Updated
- 2024/03/01
TCI Chemical
- Product number
- H1269
- Product name
- 3-Hydroxyxanthen-9-one
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $107
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H63495
- Product name
- 3-Hydroxyxanthone, 98%
- Packaging
- 1g
- Price
- $49
- Updated
- 2022/04/27
Alfa Aesar
- Product number
- H63495
- Product name
- 3-Hydroxyxanthone, 98%
- Packaging
- 5g
- Price
- $191
- Updated
- 2022/04/27
Usbiological
- Product number
- 241959
- Product name
- Sieber Linker
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
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Sieber Linker Chemical Properties,Usage,Production
Chemical Properties
White to off-white or grey powder
Uses
Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.
Synthesis Reference(s)
Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6
Purification Methods
Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]
Sieber Linker Preparation Products And Raw materials
Raw materials
Pyridine hydrochloride
o-Anisoyl chloride
Salicylic acid
o-Anisic acid
Phosphoric acid
1,3-Dimethoxybenzene
Zinc chloride
Phosphorus oxychloride
Resorcinol
Hydrochloric acid
Phosphorus pentoxide
Preparation Products
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View Lastest Price from Sieber Linker manufacturers
Shaanxi TNJONE Pharmaceutical Co., Ltd
- Product
- Sieber Linker 3722-51-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-15
Suzhou Eebetter Biotechnology Co., Ltd.
- Product
- SieberLinker 3722-51-8
- Price
- US $70344.80-5944827.00/kg
- Min. Order
- 100kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2023-08-30
Henan Aochuang Chemical Co.,Ltd.
- Product
- Sieber Linker 3722-51-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-22
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