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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

Product Name
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
CAS No.
99754-06-0
Chemical Name
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
Synonyms
ONO-RS-082;2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID;2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid;4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid;2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt;4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363);4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
CBNumber
CB3723445
Molecular Formula
C21H22ClNO3
Formula Weight
371.86
MOL File
99754-06-0.mol
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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Property

Melting point:
175-177℃
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white
Sensitive 
Light Sensitive
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
HazardClass 
9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O0766
Product name
ONO-RS-082
Purity
≥97% (HPLC)
Packaging
5mg
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
O0766
Product name
ONO-RS-082
Purity
≥97% (HPLC)
Packaging
25mg
Price
$475
Updated
2024/03/01
Alfa Aesar
Product number
J67444
Product name
ONO-RS-082, 98%
Packaging
20mg
Price
$141
Updated
2023/06/20
Cayman Chemical
Product number
20243
Product name
ONO-RS-082
Purity
≥98%
Packaging
100mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
20243
Product name
ONO-RS-082
Packaging
25mg
Price
$130
Updated
2024/03/01
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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Chemical Properties,Usage,Production

Description

ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5

Uses

ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor.

in vitro

previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].

References

1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197 2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361 3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530 4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004 5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Suppliers

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99754-06-0, 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACIDRelated Search:

Citicoline sodium U-73343 Phosphatidylinositol (Soy) SodiuM ARISTOLOCHIC ACID SODIUM SALT ISOTETRANDRINE 2-Heptadecanone OLEYLOXYETHYL PHOSPHORYLCHOLINE BROMOENOL LACTONE Thioetheramide PC UMBELLIFERYL ARACHIDONATE LUFFARIELLOLIDE 2-Amino-4-chlorobenzoic acid AKOS BBS-00007306 2-AMINO-4-CHLORO-BENZENEMETHANOL ACA 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID 2-(ACETYLAMINO)-4-CHLOROBENZOIC ACID 2-(p-amylcinnamoyl)-amino-4-chlorobenzoic acid (ONO-RS-082)

  • 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
  • ONO-RS-082
  • 2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid
  • 2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt
  • 4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
  • (E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid
  • (E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363)
  • 4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid
  • Benzoic acid, 4-chloro-2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-
  • 4-chloro-2-[3-(4-pentylphenyl)prop-2-enoylamino]benzoic acid
  • lung,neutrophils,hepoxilin,ONO RS 082,prostaglandin,arachidonic,inhibit,inflammation,Phospholipase,Inhibitor,ONORS082,acid
  • 4-Chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid
  • 99754-06-0