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Idarubicin hydrochloride

Product Name
Idarubicin hydrochloride
CAS No.
57852-57-0
Chemical Name
Idarubicin hydrochloride
Synonyms
IDARUBICIN HCL;Zavedos;CS-1673;(7S,9S)-;4-DMD HCl;4-DMDR) HCl;Idarubicin HCI;Ida Bixing ketone;Idarubicin HCl API;Idarubicin hcl USP/EP
CBNumber
CB3727751
Molecular Formula
C26H28ClNO9
Formula Weight
533.95
MOL File
57852-57-0.mol
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Idarubicin hydrochloride Property

Melting point:
183-185 C
alpha 
D20 +205° (c = 0.1 in methanol) (Arcamone); D20 +188° (c = 0.10 in methanol) (Kimura)
storage temp. 
Inert atmosphere,2-8°C
solubility 
≥26.7 mg/mL in DMSO; insoluble in EtOH; ≥2.39 mg/mL in H2O with ultrasonic
form 
solid
color 
Orange to red
Stability:
Hygroscopic, Light Sensitive
InChIKey
JVHPTYWUBOQMBP-RVFAQHLVSA-N
SMILES
C12=C(O)C3=C(C(=O)C4C=CC=CC=4C3=O)C(O)=C1C[C@@](O)(C(=O)C)C[C@]2([H])O[C@@H]1O[C@H]([C@@H](O)[C@@H](N)C1)C.Cl |&1:19,25,28,30,31,33,r|
CAS DataBase Reference
57852-57-0
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Safety

Hazard Codes 
T+,Xn
Risk Statements 
60-61-28-40
Safety Statements 
53-45-36-22
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
HB7877000
HS Code 
2941906000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2704
Product name
Idarubicin hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
75MG
Price
$575
Updated
2024/03/01
Sigma-Aldrich
Product number
I1656
Product name
Idarubicin hydrochloride
Purity
solid
Packaging
10mg
Price
$261
Updated
2024/03/01
Sigma-Aldrich
Product number
1335701
Product name
Idarubicin
Packaging
50mg
Price
$1340
Updated
2024/03/01
Cayman Chemical
Product number
14176
Product name
Idarubicin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
14176
Product name
Idarubicin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
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Idarubicin hydrochloride Chemical Properties,Usage,Production

Description

Idarubicin hydrochloride is a derivative of daunorubicin indicated for acute nonlymphocytic leukemia, acute lymphocytic leukemia, and acute myeloid leukemia. Compared with daunorubicin, idarubicin hydrochloride is less cardiotoxic, has milder side effects, is orally active and more potent in experimental leukemias. Idarubicin hydrochloride is also reportedly active in daunorubicin-resistant patients, breast cancer,Hodgkin's and non-Hodgkin's lymphoma.

Chemical Properties

Orange Solid

Originator

Erbamont (Italy)

Uses

Idarubicin hydrochloride (Idamycin) is used to traet acute myeloid leukemia in adults.

Uses

Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL

Uses

Orally active anthracycline; analog of Daunorubicin. Antineoplastic

Definition

ChEBI: Idarubicin hydrochloride is an anthracycline.

brand name

Zavedos

General Description

Idarubicin is available in 5-, 10-, and 20-mL vials for IV administrationin the treatment of acute myeloid leukemia andacute nonlymphocytic leukemia. The compound lacks the4-methoxy group and terminal side-chain alcohol of doxorubicinmaking it the most lipophilic of the four major anthracyclines(doxorubicin, daunorubicin, epirubicin, idarubicin),and it is considered less cardiotoxic than doxorubicin. Theremoval of the 4-methoxy group also increases inhibition oftopoisomerase II. The drug has a fast distributive phase anda high volume of distribution reflecting binding to tissue.Concentrations in blood and bone marrow cells are 100 timeshigher than those found in plasma, reflecting its use in treatingleukemias. Metabolism of the agent primarily occurs byconversion to idarubicinol via reduction of the side chain ketoneto the alcohol, which retains activity as an antineoplastic.Elimination occurs primarily in the bile. Adverse effectsare similar to those found for doxorubicin; however, there isa lower incidence of cardiotoxicity.

Trade name

Idamycin PFS, Idamycin?

Mechanism of action

Increased rates of remission have been noted with the use of idarubicin compared to other anthracyclines antineoplastic agents. Unlike its congeners, idarubicin shows significant oral bioavailability and is lipophilic enough to penetrate the blood-brain barrier. Currently, however, it is given only by the IV route and is not used in the treatment of brain cancer.

Clinical Use

Its primary indication is in acute myeloid leukemia, and it is administered in combination with other antileukemic drug.

Side effects

Common adverse reactions to Idarubicin hydrochloride may include nausea and vomiting, mucositis, and some patients may experience serious adverse reactions including transient elevation of hepatic aminotransferases and total bilirubin, alopecia, transient rash, urticaria at the site of injection, and skin toxicity[1].

Safety Profile

A poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl-.

Drug interactions

Potentially hazardous interactions with other drugs
Other myelosuppressant medication and radiotherapy: increased risk of myelosuppression.
Antipsychotics: avoid concomitant use with clozapine, increased risk of agranulocytosis.
Ciclosporin: concentration increased by ciclosporin.
Cytotoxics: possible increased cardiotoxicity with trastuzumab.
Live vaccines: risk of generalised infections - avoid.

Metabolism

Idarubicin is reduced by aldoketoreductases to idarubicinol, which is as active as the parent drug. Because there is no aromatic methoxy group, there is no O-dealkylation to the C4-phenol. The major metabolite is free, unconjugated idarubicinol. The half-lives of both idarubicin and idarubicinol are 22 and 45 hours, respectively. Idarubicin is administered IV at a dose of 10 to 12 mg/m2 /day for 3 to 4 days, and the idarubicinol metabolite can still be found in therapeutic concentrations in the blood 8 days after administration. Like other anthracyclines, excretion primarily is fecal, with a lesser dependence on renal elimination.

References

[1] S M FIELDS  J M K. Idarubicin: a second-generation anthracycline.[J]. DICP?: the annals of pharmacotherapy, 1991, 25 5: 505-517. DOI:10.1177/106002809102500511.

References

[1] h. dorota halicka, m. fevzi ozkaynak, oya levendoglu-tugal, claudio sandoval , karen seiter, malgorzata kajstura, frank traganos, somasunadaram jayabose, and zbigniew darzynkiewicz. dna damage response as a biomarker in treatment of leukemias. cell cycle. 2009, 8(11): 1720–1724.
[2] haydar çelik and emel arinç. evaluation of the protective effects of quercetin, rutin, resveratrol, naringenin and trolox against idarubicin-induced dna damage. j pharm pharmaceut sci. 2010, 13(2): 231 – 241.
[3] ching-hon pui, siebold s. n. de graaf, lois w. dow, john h. rodman, william e. evans, bruce s. alpert and sharon b. murphy. phase i clinical trial of orally administered 4-demethoxydaunorubicin (idarubicin) with pharmacokinetic and in vitro drug sensitivity testing in children with refractory leukemia. cancer research. 1988, 48: 5348-5352.

Idarubicin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Idarubicin hydrochloride Suppliers

SYNBIAS PHARMA AG
Tel
--
Fax
--
Email
info@synbiaspharma.ch
Country
Switzerland
ProdList
7
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Idarubicin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Idarubicin hydrochloride 57852-57-0
Price
US $0.00/g
Min. Order
1g
Purity
99%min
Supply Ability
1000g
Release date
2021-11-16
shandong perfect biotechnology co.ltd
Product
Idarubicin Hydrochloride 57852-57-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
5000kgs
Release date
2023-07-07
Hebei Weibang Biotechnology Co., Ltd
Product
Idarubicin hydrochloride / Idarubicin hcl 57852-57-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25

57852-57-0, Idarubicin hydrochlorideRelated Search:


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  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • DNA metabolism
  • DNA Synthesis Inhibitors
  • Idamycin, Zavedos, 4-demethoxydaunorubicin
  • Drug Analogues
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
  • Anti-cancer&immunity
  • Inhibitors