Carbimazole
- Product Name
- Carbimazole
- CAS No.
- 22232-54-8
- Chemical Name
- Carbimazole
- Synonyms
- Carbimazol;Carbinazole;Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate;CG1;NUPL2;Tyrazol;Basolest;CARBIMAZOLE;Athyromazole;Neomercazole
- CBNumber
- CB3731303
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 22232-54-8.mol
Carbimazole Property
- Melting point:
- 124°C
- Boiling point:
- 240.4±23.0 °C(Predicted)
- Density
- 1.2900 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- -1.70±0.20(Predicted)
- color
- white to beige
- Water Solubility
- Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.
- Sensitive
- Light Sensitive
- Merck
- 14,1798
- BRN
- 144339
- InChIKey
- CFOYWRHIYXMDOT-UHFFFAOYSA-N
- CAS DataBase Reference
- 22232-54-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Carbimazole(22232-54-8)
Safety
- Risk Statements
- 22-36-43
- Safety Statements
- 22-36/37/39
- RIDADR
- 3335
- WGK Germany
- 3
- RTECS
- NJ2441000
- HS Code
- 2933.29.9000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
N-Bromosuccinimide Price
- Product number
- SML0931
- Product name
- Carbimazole
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $29.4
- Updated
- 2024/03/01
- Product number
- PHR1684
- Product name
- Carbimazole
- Packaging
- 1g
- Price
- $214
- Updated
- 2024/03/01
- Product number
- C1080
- Product name
- Carbimazole
- Purity
- >95.0%(HPLC)
- Packaging
- 5g
- Price
- $65
- Updated
- 2024/03/01
- Product number
- C1080
- Product name
- Carbimazole
- Purity
- >95.0%(HPLC)
- Packaging
- 25g
- Price
- $195
- Updated
- 2024/03/01
- Product number
- L08218
- Product name
- Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97%
- Packaging
- 25g
- Price
- $206.65
- Updated
- 2024/03/01
Carbimazole Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Carbimazol,Cid Co.
Uses
Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.
Uses
Thionamide antithyroid drug.
Uses
Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.
Definition
ChEBI: A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Manufacturing Process
0.1 mol of 1-methyl-2-mercaptoglyoxaline is dissolved in the minimum quantity of pyridine at 0°C 0.1 mol of ethyl chloroformate is added drop wise with stirring. More pyridine is added, if necessary, to keep the mixture semi-fluid. The sludge is then placed in an ice bath for 30 minutes. The crystals are filtered off and washed firstly with a little ethanol and secondly with ethanol and water. The non-basic desired ethyl 3-methyl-2-thioimidazoline-1- carboxylate is the colourless needles having a melting point of 122°-123°C.
Therapeutic Function
Thyroid inhibitor
Clinical Use
Treatment of hyperthyroidism
Synthesis
Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-1-carboxylic acid (25.2.7), is synthesized by a simultaneous reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7).
Veterinary Drugs and Treatments
Carbimazole (a pro-drug of methimazole) or methimazole are
considered by most clinicians to be the agents of choice when using
drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to
methimazole.
Methimazole and therefore, carbimazole, may be useful for the
prophylactic prevention of cisplatin-induced nephrotoxicity in dogs.
Metabolism
Carbimazole is rapidly metabolised to thiamazole, which is concentrated in the thyroid gland. Over 90% of orally administered carbimazole is excreted in the urine as thiamazole or its metabolites. The remainder appears in faeces. There is 10% enterohepatic circulation. Thiamazole is metabolised, probably by the liver, and excreted in the urine. Less than 12% of a dose of thiamazole may be excreted as unchanged drug
Carbimazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbimazole manufacturers
- Product
- Carbimazole 22232-54-8
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min; BP
- Supply Ability
- 500kg
- Release date
- 2021-09-18
- Product
- Carbimazole 22232-54-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Carbimazole 22232-54-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08