Carbimazole

Product Name: Carbimazole
CAS No.: 22232-54-8
Chemical Name: Carbimazole
Synonyms: Carbimazol;Carbinazole;Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate;CG1;NUPL2;Tyrazol;Basolest;CARBIMAZOLE;Athyromazole;Neomercazole
CBNumber: CB3731303
Molecular Formula: C7H10N2O2S
Formula Weight: 186.23
MOL File: 22232-54-8.mol

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Carbimazole Property

Melting point:: 124°C
Boiling point:: 240.4±23.0 °C(Predicted)
Density: 1.2900 (rough estimate)
refractive index: 1.5400 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: -1.70±0.20(Predicted)
color: white to beige
Water Solubility: Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.
Sensitive: Light Sensitive
Merck: 14,1798
BRN: 144339
InChIKey: CFOYWRHIYXMDOT-UHFFFAOYSA-N
CAS DataBase Reference: 22232-54-8(CAS DataBase Reference)
NIST Chemistry Reference: Carbimazole(22232-54-8)

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Safety

Risk Statements: 22-36-43
Safety Statements: 22-36/37/39
RIDADR: 3335
WGK Germany: 3
RTECS: NJ2441000
HS Code: 2933.29.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0931
Product name: Carbimazole
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $29.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1684
Product name: Carbimazole
Packaging: 1g
Price: $214
Updated: 2024/03/01

TCI Chemical

Product number: C1080
Product name: Carbimazole
Purity: >95.0%(HPLC)
Packaging: 5g
Price: $65
Updated: 2024/03/01

TCI Chemical

Product number: C1080
Product name: Carbimazole
Purity: >95.0%(HPLC)
Packaging: 25g
Price: $195
Updated: 2024/03/01

Alfa Aesar

Product number: L08218
Product name: Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97%
Packaging: 25g
Price: $206.65
Updated: 2024/03/01

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Carbimazole Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Carbimazol,Cid Co.

Uses

Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.

Uses

Thionamide antithyroid drug.

Uses

Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.

Definition

ChEBI: A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.

Manufacturing Process

0.1 mol of 1-methyl-2-mercaptoglyoxaline is dissolved in the minimum quantity of pyridine at 0°C 0.1 mol of ethyl chloroformate is added drop wise with stirring. More pyridine is added, if necessary, to keep the mixture semi-fluid. The sludge is then placed in an ice bath for 30 minutes. The crystals are filtered off and washed firstly with a little ethanol and secondly with ethanol and water. The non-basic desired ethyl 3-methyl-2-thioimidazoline-1- carboxylate is the colourless needles having a melting point of 122°-123°C.

Therapeutic Function

Thyroid inhibitor

Clinical Use

Treatment of hyperthyroidism

Synthesis

Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-1-carboxylic acid (25.2.7), is synthesized by a simultaneous reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7).

Veterinary Drugs and Treatments

Carbimazole (a pro-drug of methimazole) or methimazole are considered by most clinicians to be the agents of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole.
Methimazole and therefore, carbimazole, may be useful for the prophylactic prevention of cisplatin-induced nephrotoxicity in dogs.

Metabolism

Carbimazole is rapidly metabolised to thiamazole, which is concentrated in the thyroid gland. Over 90% of orally administered carbimazole is excreted in the urine as thiamazole or its metabolites. The remainder appears in faeces. There is 10% enterohepatic circulation. Thiamazole is metabolised, probably by the liver, and excreted in the urine. Less than 12% of a dose of thiamazole may be excreted as unchanged drug

Carbimazole Preparation Products And Raw materials

Raw materials

Methylamine Ethyl chloroformate 2-MERCAPTOIMIDAZOLE Chloroacetaldehyde diethyl acetal Potassium thiocyanate (2,2-diethoxyethyl)methylamine

Preparation Products

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Carbimazole Suppliers

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View Lastest Price from Carbimazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Carbimazole 22232-54-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min; BP
Supply Ability: 500kg
Release date: 2021-09-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carbimazole 22232-54-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carbimazole 22232-54-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

22232-54-8, CarbimazoleRelated Search:

Thiophanate-methyl Bensulfuron methyl Methylparaben Imidazolidine RESMETHRIN Sodium thiosulfate Methyl acetate Thioacetamide Ethyl imidazole-4-carboxylate Methyl acrylate Kresoxim-methyl Imidazole Methyl Parathion-methyl Methyl bromide TRIMETHYLTHIOUREA DIMETHYLAMMONIUM DIMETHYLCARBAMATE(DIMCARB) noxytiolin

CARBIMAZOLE

ETHYL 3-METHYL-2-THIOMIDAZOLINE-1-CARBOXYLATE

ETHYL 3-METHYL-2-THIONOIMIDAZOLINE-1-CARBOXYLATE

LABOTEST-BB LT00455569

Ethyl 3-methyl-2-thioxo-4-imidazoline-1-carboxylate

1-Methyl-2-imidazolethiol ethyl carbamate

3-methyl-2-thionoimidazoline-1-carboxylic acid ethyl ester

1-ETHOXYCARBONYL-3-METHYL-2-THIOXO-4-IMIDAZOLINE

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

O-ethylS-(1-methylimida-zol-2-yl)carbamate

Tyrazol

1-Methyl-3-carbethoxy-2-thioglyoxalone

ethyl 3-Methyl-2-sulfanylidene-2,3-dihydro-1H-iMidazole-1-carboxylate

ANTI-NUPL2 (N-TERM) antibody produced in rabbit

Nucleoporin hCG1

Nucleoporin-like protein 2

NUP42 homolog

NUPL2

1-Ethoxycarbonyl-3- Methyl-2-thio-4-iMidazoline

CARBIMAZOLE EP

3-methyl-2-sulfanylidene-1-imidazolecarboxylic acid ethyl ester

1h-imidazole-1-carboxylicacid,2,3-dihydro-3-methyl-2-thioxo,ethylester

2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylicacidethylester

2-Carbethoxythio-1-methylimidazole

3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester

3-methyl-2-thioxo-4-imidazoline-1-carboxylicacidethylester

3-methyl-2-thioxo-4-imidazoline-1-carboxylicaciethylester

4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester

Athyromazole

Basolest

Carbethoxymethimazole

Carbimazol

Carbinazole

CG1

Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate

Neomercazole

Neo-thyreostat

Methyl-2-imidazol-thiol carbonate ethyl ester

Carbimazole &gt

Carbimazole CRS

Carbimazole USP/EP/BP

CarbimazoleTablets

Carbimazole (C0465000)Q: What is Carbimazole (C0465000) Q: What is the CAS Number of Carbimazole (C0465000) Q: What are the applications of Carbimazole (C0465000)

Carbimazole D3Q: What is Carbimazole D3 Q: What is the CAS Number of Carbimazole D3 Q: What is the storage condition of Carbimazole D3 Q: What are the applications of Carbimazole D3

CarbimazoleQ: What is Carbimazole Q: What is the CAS Number of Carbimazole Q: What is the storage condition of Carbimazole Q: What are the applications of Carbimazole

ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate

CARBIMAZOLE IP

22232-54-8

API

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds