Torcetrapib

Product Name: Torcetrapib
CAS No.: 262352-17-0
Chemical Name: Torcetrapib
Synonyms: cp529;CS-156;CP 529414;Torcetropib;Torcetrapib;TORCETRAPIB-D3;Torcetrapib USP/EP/BP;Torcetrapib (CP-529414);(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
CBNumber: CB3739389
Molecular Formula: C26H25F9N2O4
Formula Weight: 600.47
MOL File: 262352-17-0.mol

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Torcetrapib Property

Melting point:: 54-58°C
Boiling point:: 504.8±50.0 °C(Predicted)
Density: 1.42
storage temp.: Store at RT
solubility: DMSO: >5mg/mL
pka: -1.87±0.40(Predicted)
form: powder
color: white
optical activity: [α]/D >-70°
CAS DataBase Reference: 262352-17-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0170
Product name: Torcetrapib
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0170
Product name: Torcetrapib
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 15028
Product name: Torcetrapib
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 15028
Product name: Torcetrapib
Purity: ≥98%
Packaging: 10mg
Price: $137
Updated: 2024/03/01

Cayman Chemical

Product number: 15028
Product name: Torcetrapib
Purity: ≥98%
Packaging: 50mg
Price: $577
Updated: 2024/03/01

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Torcetrapib Chemical Properties,Usage,Production

Chemical Properties

Off-White Low Melting Solid

Uses

Cholesteryl ester transfer protein (CETP) inhibitor. Antilipemic; antiatherosclerotic.

Definition

ChEBI: Torcetrapib is a member of quinolines, a carbamate ester and a member of (trifluoromethyl)benzenes. It has a role as an anticholesteremic drug and a CETP inhibitor.

Biological Activity

torcetrapib is a cetp inhibitor with ic50 of 37 nm, elevates hdl-c and reduces nonhdl-c in plasma. inhibition of cholesteryl ester transfer protein (cetp) has been shown to have a substantial effect on plasma lipoprotein levels.

in vitro

torcetrapib dose-dependently increases aldosterone release from h295r cells after either 24 or 48 h of treatment, this effect is mediated by calcium channel as calcium channel blockers completely blocks torcetrapib-induced corticoid release and calcium increase. torcetrapib (1 μm) significantly increases the expression of steroidogenic gene, cyp11b2 and cyp11b1, in h295r cell lines [1].

in vivo

researchers tested torcetrapib in rabbits fed an atherogenic diet at a dose sufficient to increase hdl-c by at least 3-fold. cetp activity was inhibited by 70–80% throughout the study. non-hdl-c increased in both groups, but there was no difference apparent by the study’s end [2].

storage

Room temperature

References

[1] hu x, dietz jd, xia c, knight dr, loging wt, smith ah, yuan h, perry da, keiser j. torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. endocrinology. 2009;150(5):2211-9.
[2] morehouse la, sugarman ed, bourassa pa, sand tm, zimetti f, gao f, rothblat gh, milici aj. inhibition of cetp activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in new zealand white rabbits. j lipid res. 2007;48(6):1263-72.
[3] barter pj, caulfield m, eriksson m, grundy sm, kastelein jj, komajda m, lopez-sendon j, mosca l, tardif jc, waters dd, shear cl, revkin jh, buhr ka, fisher mr, tall ar, brewer b; illuminate investigators. effects of torcetrapib in patients at high risk for coronary events. n engl j med. 2007;357(21):2109-22.

Torcetrapib Preparation Products And Raw materials

Raw materials

Preparation Products

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Torcetrapib Suppliers

Canada 3 China 84 Europe 2 India 4 South Korea 1 United Kingdom 4 United States 21 Global 119

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262352-17-0, TorcetrapibRelated Search:

Methoxydiethylborane (Trifluoromethoxy)benzene Anisole Ethylbenzene Ethylparaben Ethyl cellulose p-Anisaldehyde CHLOROETHANE Benzyltriethylammonium chloride Ethyl acetate Ethanol Ethyl acrylate Ethyl formate p-Anisidine p-(2-Methoxyethyl) phenol Diethyl ether CHEMBRDG-BB 6596991 Torcetrapib

CP 529414

(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

Torcetrapib (CP-529414)

cp529

(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

Torcetropib

CS-156

TORCETRAPIB-D3

(2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester

(2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylicacidethylester

Torcetrapib

1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-

Torcetrapib USP/EP/BP

262352-17-0

C26H25F9N2O4

Inhibitor

Aromatics

Chiral Reagents

Inhibitors

Intermediates & Fine Chemicals

Pfizer compounds

Pharmaceuticals