(S)-(+)-2-Methylpiperazine
- Product Name
- (S)-(+)-2-Methylpiperazine
- CAS No.
- 74879-18-8
- Chemical Name
- (S)-(+)-2-Methylpiperazine
- Synonyms
- S-MP;CADR-011;L-(+)-2-Meth;(S)-2-METHYLPIPERAZINE;2-(S)-METHYLPIPERAZINE;(2S)-2-Methylpiperazine;L-(+)-2-Methylpiperazine;S-(+)-2-methylpyperazine;(S)-(+)-2-METHYLPIPERZINE;(S)-(+)-2-METHYLPIPERAZINE
- CBNumber
- CB3781696
- Molecular Formula
- C5H12N2
- Formula Weight
- 100.16
- MOL File
- 74879-18-8.mol
(S)-(+)-2-Methylpiperazine Property
- Melting point:
- 91-93 °C(lit.)
- Boiling point:
- 155-156 °C
- alpha
- 13.5 º (c=1, toluene)
- Density
- 0.9305 (estimate)
- refractive index
- 1.4378 (estimate)
- Flash point:
- 149 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Crystalline Powder, Crystals and/or Chunks
- pka
- 9.31±0.40(Predicted)
- color
- White to yellow
- optical activity
- [α]20/D +6.8°, c = 1 in ethanol
- Water Solubility
- soluble
- Sensitive
- Air Sensitive & Hygroscopic
- BRN
- 3647995
- InChIKey
- JOMNTHCQHJPVAZ-YFKPBYRVSA-N
- CAS DataBase Reference
- 74879-18-8(CAS DataBase Reference)
Safety
- Hazard Codes
- F,Xi,C
- Risk Statements
- 11-36/37/38-34
- Safety Statements
- 16-26-36/37/39-45-36
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- RTECS
- TM1225020
- HazardClass
- 4.1
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 397172
- Product name
- (S)-(+)-2-Methylpiperazine
- Purity
- 99%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- 397172
- Product name
- (S)-(+)-2-Methylpiperazine
- Purity
- 99%
- Packaging
- 5g
- Price
- $91.5
- Updated
- 2023/06/20
- Product number
- M1424
- Product name
- (S)-(+)-2-Methylpiperazine
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- M1424
- Product name
- (S)-(+)-2-Methylpiperazine
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $164
- Updated
- 2025/07/31
- Product number
- M302705
- Product name
- (2S)-2-Methylpiperazine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
(S)-(+)-2-Methylpiperazine Chemical Properties,Usage,Production
Chemical Properties
white to yellow crystalline powder or chunks
Uses
Valuable synthon for quinoline antibacterials.
Synthesis
109-07-9
75336-86-6
74879-18-8
General procedure for the synthesis of (R)-(-)-2-methylpiperazine and (S)-2-methylpiperazine from 2-methylpiperazine: 1. In a 2L four-necked flask equipped with a thermometer, a vacuum stirrer and a cooling tube, 270 g (1.8 mol) of L-tartaric acid, 108 g (1.8 mol) of acetic acid and 270 g of water were added and stirred until completely dissolved. 2. add (±)-2-methylpiperazine 300 g (3.0 mol) and water 300 g. Heat to 85 °C or higher until completely dissolved. 3. cool to 68-74°C, add diastereomerically precipitated crystals of (R)-2-methylpiperazine and L-tartaric acid and age for 1 hour. 4. cooled to 12-18 °C over 5 h and filtered to obtain 440 g of wet biomass (diastereomeric salt) with a liquid content of 22.7 wt% and an optical purity of 92.3% ee. 5. 644 g of water and 440 g of the resulting crystals ((R)-2-methylpiperazine pure content = 132 g) were added to a 2L four-neck flask, followed by 162 g (2.2 mol) of calcium hydroxide, heated to 80 °C, and aged for 5 hours. 6. Cooled to 25 °C and filtered to give 586 g of crystals (mainly calcium L-tartrate) and 660 g of filtrate (containing 130 g of (R)-2-methylpiperazine). 7. The filtrate was concentrated under reduced pressure to a (R)-2-methylpiperazine concentration of 30%, 356 g of toluene was added, and the water was removed by azeotropic boiling by heating to 84-87 °C. 8. 212 g of toluene was distilled under reduced pressure, cooled to 47 °C, 0.01 g of (R)-2-methylpiperazine crystal seed was added and aged for 1 hour. 9. cooled to 5 °C, aged for 2 h, filtered and dried under vacuum to give 45 g of (R)-2-methylpiperazine crystals (chemical purity 100%, optical purity 99.5% ee). 10. For the synthesis of (S)-2-methylpiperazine, a similar procedure was used but with (S)-2-methylpiperazine as starting material, resulting in 66.8 g of (S)-2-methylpiperazine crystals (chemical purity 99.9%, optical purity 80.0%ee).
References
[1] Patent: JP2016/37495, 2016, A. Location in patent: Paragraph 0046-0052
(S)-(+)-2-Methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-2-Methylpiperazine Suppliers
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View Lastest Price from (S)-(+)-2-Methylpiperazine manufacturers
- Product
- (S)-(+)-2-Methylpiperazine 74879-18-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08
- Product
- (S)-(+)-2-Methylpiperazine 74879-18-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- As customer's need
- Supply Ability
- CARA34
- Release date
- 2018-12-14