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phosphorylcholine

Product Name
phosphorylcholine
CAS No.
107-73-3
Chemical Name
phosphorylcholine
Synonyms
PHOSPHOCHOLINE;N,N,N-trimethyl-2-(phosphonooxy)ethan-1-aminium chloride;o-Phosphocholine;Phosphocholine chloride;Choline phosphate;Phosphorylchline;phosphorylcholine;O-Phosphonocholine;choline chloride O-;Cyclazosin Impurity 3
CBNumber
CB3874749
Molecular Formula
C5H15ClNO4P
Formula Weight
219.6
MOL File
107-73-3.mol
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phosphorylcholine Property

Melting point:
108-111 °C (decomp)
Boiling point:
103 °C(Press: 12 Torr)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Sparingly)
form 
Oil
color 
Colourless
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P354508
Product name
Phosphocholine
Packaging
250mg
Price
$65
Updated
2021/12/16
Crysdot
Product number
CD53000597
Product name
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumchloride
Purity
95+%
Packaging
5mg
Price
$145
Updated
2021/12/16
Alichem
Product number
107733
Product name
N,N,N-Trimethyl-2-(phosphonooxy)ethanaminiumchloride
Packaging
25g
Price
$400
Updated
2021/12/16
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phosphorylcholine Chemical Properties,Usage,Production

Description

Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of some phospholipids, which is composed of a negatively charged phosphate bonded to a small, positively charged choline group. It is a choline ester which forms a part of the phosphatide molecule, and as such occurs in nearly all organs. It probably often exists in the free state, being liberated from the phosphatides by enzymic hydrolysis.

Chemical Properties

White crystal or crystalline powder, slightly fishy odor. Melting point 200~205°C(sealed tube). Has deliquescence. Insoluble in general organic solvents such as benzene, chloroform and ether, slightly soluble in ethanol and acetone, soluble in methanol, easily soluble in water, 10% aqueous solution pH=4.8~5.0.

Characteristics

Phosphorylcholine, unlike most of the choline esters, is very stable towards alkaline and acid hydrolytic agents; this stability is attributed to the betaine structure of the compound. It is hydrolysed by kidney, bone, and serum phosphatase.

Uses

Phosphocholine is an intermediate in the synthesis of Uridine Diphosphate Choline Ammonium Salt (U829930), which is CDPcholine cholinephosphotransferase analog. Pipeline device with Phosphorylcholine surface treatment (Pipeline Shield) could mitigate device material related thromboembolic complications.

Preparation

Phosphorylcholine was synthesised from choline chloride and phosphorus pentoxide, the solvent being 100 percent. phosphoric acid [phosphorylation method of Manaka, 1931]. 2.4 g choline chloride, dried over phosphorus pentoxide, were dissolved in 15 g. 100 per cent. phosphoric acid, the solution was heated at 70°C. in vacuo until evolution of HC1 ceased, and 5 g. phosphorus pentoxide were added. The mixture, which became homogeneous after a few minutes, was kept at 70°C. for 3 hours. The clear viscous solution was poured into 400c.c. of ice water, and a barium hydroxide solution, saturated at 50°C., was added until the solution showed a strongly alkaline reaction. At the end of the neutralisation a smell of trimethylamine appears. The barium phosphate was centrifuged, the excess of barium ions removed by carbon dioxide, the precipitate centrifuged, and the solution reduced in vacuo to a small volume. It still contained a certain amount of barium ions depending on the amount of negatively charged phosphorylcholine ions present. The latter is determined by the pH of the solution. The amount of barium ions present was determined in an aliquot part of the solution by precipitation with sulphuric acid, and the amount of n-sulphuric acid required for complete precipitation of the barium ions added.

Definition

ChEBI: Phosphorylcholine chloride is an organic chloride salt comprising a choline phosphate cation and chloride anion. It contains a phosphocholine and a chloride.

Enzyme inhibitor

This choline phosphomonoester (FWzwitterion = 183.14 g/mol; CAS 107-73- 3), also known as choline phosphate and phosphorylcholine, is a key intermediate in the biosynthesis of many phospholipids. Both the free acid and the calcium salt are very soluble in water. The free acid is relatively stable in acidic conditions: only 15% is hydrolyzed in five hours in 1 M HCl at 100°C. Under alkaline conditions, there is complete hydrolysis after four hours by refluxing with barium hydroxide. The phosphocholine chloride calcium salt is stable for months at room temperature. Target(s): 1-alkyl-2-acetylglycerophosphocholine esterase, or platelet-activatingfactor acetylhydrolase; choline-sulfatase; choline sulfotransferase; ethanolamine kinase; ethanolamine-phosphate cytidylyltransferase; glutamate decarboxylase; glycerophosphocholine cholinephosphodiesterase; ornithine decarboxylase; phosphoethanolamine Nmethyltransferase; phosphoserine phosphatase; and sphingomyelin phosphodiesterase, or sphingomyelinase.

phosphorylcholine Preparation Products And Raw materials

Raw materials

Preparation Products

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phosphorylcholine Suppliers

MedChemexpress LLC
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021-58955995
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Alfa Chemistry
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Alfa Chemistry
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Cato Research Chemicals Inc.
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020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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Aceschem Inc.
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United States
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MedChemExpress
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Waterstone Technology, LLC
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HONEST JOY HOLDINGS LIMITED
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View Lastest Price from phosphorylcholine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
phosphorylcholine 107-73-3
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-08
Sinoway Industrial co., ltd.
Product
Phosphorylcholine 107-73-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-05-31
Hebei Weibang Biotechnology Co., Ltd
Product
phosphorylcholine 107-73-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01

107-73-3, phosphorylcholineRelated Search:


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  • C5H16NO5P
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  • C5H15ClNO4P