Anticancer drugs
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Cediranib

Anticancer drugs
Product Name
Cediranib
CAS No.
288383-20-0
Chemical Name
Cediranib
Synonyms
CS-377;AZD2171;Recentin;Cediranib;Cadiranib;NSC-732208;Cediranib R;Cediranib, >=99%;Cediranib (AZD217);Cediranib(AZD2171)
CBNumber
CB3947063
Molecular Formula
C25H27FN4O3
Formula Weight
450.51
MOL File
288383-20-0.mol
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Cediranib Property

Melting point:
135-138°C
Boiling point:
626.6±55.0 °C(Predicted)
Density 
1.285
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
16.14±0.30(Predicted)
color 
White to Off-White
InChI
InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
InChIKey
XXJWYDDUDKYVKI-UHFFFAOYSA-N
SMILES
N1=C2C(C=C(OC)C(OCCCN3CCCC3)=C2)=C(OC2C=CC3=C(C=2F)C=C(C)N3)N=C1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2850
Product name
Cediranib
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$82.3
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2850
Product name
Cediranib
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$268
Updated
2025/07/31
TCI Chemical
Product number
C3918
Product name
Cediranib
Packaging
5MG
Price
$102
Updated
2025/07/31
Cayman Chemical
Product number
11495
Product name
Cediranib
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
11495
Product name
Cediranib
Purity
≥98%
Packaging
10mg
Price
$142
Updated
2024/03/01
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Cediranib Chemical Properties,Usage,Production

Anticancer drugs

Cediranib is an oral anticancer drug , it is successfully developed by the US AstraZeneca company , its trade name is recentin, this product is an efficient VEGFR tyrosine kinase inhibitor, it is capable of inhibiting all known VEGFR tyrosine kinases ( including VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR). Cediranib can inhibit VEGF-induced angiogenesis, neovascularization survival and human tumor xenograft cell growth.Clinical trail phase I for non-small cell lung cancer (abbreviated NSCLC) patients shows that cediranib in combination with PC programs has a significant antitumor effect . Clinical trail phaseⅡ/Ⅲ BR24 focuses on using cediranib 30mg as a first-line treatment of NSCLC ,which demonstrates that it has anti-tumor effect, but it has a higher incidence of adverse events, including diarrhea, dehydration, hand-foot syndrome, hypertension and neutropenia disease. Therefore, there is the decision to stop clinical trials. Repeated assessments about toxicity and dose of the combination of drugs suggest that part of the adverse effects are dose-related , dose reduction may be tried to improve drug tolerance. In view of this conclusion, in 2009, the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) launched a cediranib clinical trail phase Ⅲ (BR29) for progressive NSCLC patients , the dose was adjusted to 20mg. The results have not been reported.
In 2009 ,European Society for Medical Oncology (ESMO) Annual report which is about cediranib treatment of metastatic renal cell carcinoma (referred mRCC) clinical trail phase II shows that cediranib treatment group tumor volume reducing rate is higher than the placebo group. Zurita tested Cediranib pretreatment serum cytokines and angiogenic factors ,and found that patients having low IL-10, VEGF, PIGF, SCF and MIG concentration during baseline time , have the more obvious tumor volume reduction after treatment.
The above information is edited by the chemicalbook of Tian Ye.

Description

Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy. Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively). It also potently inhibits a variety of other receptor and non-receptor tyrosine kinases, including several in the platelet-derived growth factor, fibroblast growth factor, and endothelial growth factor receptor families. Cediranib blocks tubule formation by human umbilical vein endothelial cells in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo. Because of these effects, cediranib has potential use in a range of cancers.

Uses

Cediranib (AZD2171) inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively.

Uses

Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.

Definition

ChEBI: 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether.

storage

Store at -20°C

References

[1] wedge sr, kendrew j, hennequin lf, valentine pj, barry st, brave sr, smith nr, james nh, dukes m, curwen jo, chester r, jackson ja, boffey sj, kilburn ll, barnett s, richmond gh, wadsworth pf, walker m, bigley al, taylor st, cooper l, beck s, jürgensmeier jm, ogilvie dj. azd2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. cancer res. 2005 may 15;65(10):4389-400.

Cediranib Preparation Products And Raw materials

Raw materials

Preparation Products

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Cediranib Suppliers

China 241 India 4 The Netherlands 1 United Kingdom 5 United States 25 Global 276
LGM Pharma
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View Lastest Price from Cediranib manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Cediranib 288383-20-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-05
Wuhan Boyuan Import & Export Co., LTD
Product
Cediranib 288383-20-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
500ton
Release date
2021-08-12
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Cediranib 288383-20-0
Price
US $5.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-12-24

288383-20-0, CediranibRelated Search:

Methoxydiethylborane m-Anisyl alcohol p-Anisaldehyde Anisole Methoxyacetic acid Guaiacol (Trifluoromethoxy)benzene 2-Methoxyethanol Pyrrolidine p-Anisidine POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Cediranib Maleate 4-Fluoro-5-methoxy-2-methyl-1H-indole 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 4-Fluoro-5-hydroxy-2-methylindole Quinazoline 4-FLUORO-5-HYDROXYINDOLE 6-METHOXYQUINAZOLIN-4-OL

  • Cediranib
  • 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
  • Cadiranib (AZD2171)
  • Cediranib(AZD2171)
  • AZD2171
  • Recentin
  • Cadiranib
  • Cediranib R
  • 4-((4-fluoro-2-Methyl-1H-indol-5-yl)oxy)-6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
  • Cediranib (AZD217)
  • Cediranib dihydrochloride
  • (557795-03-6) cediranib
  • RECENTIN;AZD2171;AZD 2171;AZD-2171
  • NSC-732208
  • 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline Cediranib (AZD2171)
  • Cediranib 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
  • Cediranib, >=99%
  • CS-377
  • Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-
  • Cediranib (free base)
  • Cediranib USP/EP/BP
  • Cediranib (NSC-732208
  • 288383-20-0 Cediranib
  • AZD2171, Cediranib
  • AZD2171|||NSC-732208
  • Carprofen Impurity 8(Carprofen EP Impurity H )
  • Cediranib, 10 mM in DMSO
  • 288383-20-0
  • C25H27FN4O3
  • Inhibitors
  • Antineoplastic
  • APIs
  • 288383-20-0