1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
- Product Name
- 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
- CAS No.
- 37813-30-2
- Chemical Name
- 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
- Synonyms
- 37813-30-2);Boc-L-Hyp-oet;BOC-L-Proline Ethyl ester;Boc-L-Hydroxy-Proline Ethyl Ester;1-Boc-L-hydroxyproline ethyl ester;1-Boc-4-Hydroxy-L-Proline Ethyl Ester;(Tert-Butoxy)Carbonyl Hyp-OEt (Syrup);(4R)-1-Boc-4-hydroxy-L-proline ethyl ester;(2S,4R)-N-Boc-trans-4-hydroxy-L-proline ethyl ester;1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
- CBNumber
- CB3947104
- Molecular Formula
- C12H21NO5
- Formula Weight
- 259.3
- MOL File
- 37813-30-2.mol
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Property
- Boiling point:
- 350.2±42.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.30±0.40(Predicted)
- form
- Viscous Liquid
- color
- Colorless to light yellow
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B656630
- Product name
- (2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylicAcidEthylEster
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B656630
- Product name
- (2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylicAcidEthylEster
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- J53754
- Product name
- 1-Boc-L-hydroxyprolineethylester
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- J53754
- Product name
- 1-Boc-L-hydroxyprolineethylester
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB72259
- Product name
- Boc-Hyp-OEt
- Packaging
- 10g
- Price
- $65
- Updated
- 2021/12/16
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Chemical Properties,Usage,Production
Uses
Boc-Hyp-OEt is a proline derivative[1].
Synthesis
24424-99-5
33996-30-4
37813-30-2
Step 2: Ethyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (146.2 g, 0.747 mol) was dissolved in a solvent mixture of dichloromethane (1,600 mL) and ethanol (100 mL) and cooled to 0°C. Triethylamine (113.4 g, 1.12 mol, 156.2 mL) was added to this solution with stirring. Subsequently, di-tert-butyl dicarbonate (195.6 g, 0.90 mol) was added in batches. The reaction mixture was stirred at 0 °C for 15 minutes, then brought to room temperature and continued stirring for 16 hours. Upon completion of the reaction, the mixture was concentrated to about 800 mL and washed with water. The organic layer was dried with magnesium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 20% ethyl acetate-dichloromethane) afforded ethyl Boc-L-hydroxyproline (193.7 g, 100%) as a yellow oil. Mass spectrum (M + Na): m/e 282. 1H-NMR (CDCl3) δ 1.30 (t, 3H), 1.45 (s, 9H), 1.75 (m, 1H), 2.10 (m, 1H), 2.30 (m, 1H), 3.45 and 3.55 (d, 1H, two rotary isomers), 3.65 (dd, 1H), 4.25 (m, 2H ), 4.40 and 4.45 (t, 1H, two rotary isomers), 4.55 (broad s, 1H).
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester manufacturers
- Product
- Boc-Hyp-Oet 37813-30-2
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05
- Product
- 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester 37813-30-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-04