ChemicalBook > CAS DataBase List > 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

Product Name
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
CAS No.
37813-30-2
Chemical Name
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
Synonyms
37813-30-2);Boc-L-Hyp-oet;BOC-L-Proline Ethyl ester;Boc-L-Hydroxy-Proline Ethyl Ester;1-Boc-L-hydroxyproline ethyl ester;1-Boc-4-Hydroxy-L-Proline Ethyl Ester;(Tert-Butoxy)Carbonyl Hyp-OEt (Syrup);(4R)-1-Boc-4-hydroxy-L-proline ethyl ester;(2S,4R)-N-Boc-trans-4-hydroxy-L-proline ethyl ester;1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
CBNumber
CB3947104
Molecular Formula
C12H21NO5
Formula Weight
259.3
MOL File
37813-30-2.mol
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1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Property

Boiling point:
350.2±42.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.30±0.40(Predicted)
form 
Viscous Liquid
color 
Colorless to light yellow
optical activity
Consistent with structure
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B656630
Product name
(2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylicAcidEthylEster
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B656630
Product name
(2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylicAcidEthylEster
Packaging
500mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
J53754
Product name
1-Boc-L-hydroxyprolineethylester
Packaging
1g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
J53754
Product name
1-Boc-L-hydroxyprolineethylester
Packaging
5g
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB72259
Product name
Boc-Hyp-OEt
Packaging
10g
Price
$65
Updated
2021/12/16
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1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Chemical Properties,Usage,Production

Uses

Boc-Hyp-OEt is a proline derivative[1].

Synthesis

24424-99-5

33996-30-4

37813-30-2

Step 2: Ethyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (146.2 g, 0.747 mol) was dissolved in a solvent mixture of dichloromethane (1,600 mL) and ethanol (100 mL) and cooled to 0°C. Triethylamine (113.4 g, 1.12 mol, 156.2 mL) was added to this solution with stirring. Subsequently, di-tert-butyl dicarbonate (195.6 g, 0.90 mol) was added in batches. The reaction mixture was stirred at 0 °C for 15 minutes, then brought to room temperature and continued stirring for 16 hours. Upon completion of the reaction, the mixture was concentrated to about 800 mL and washed with water. The organic layer was dried with magnesium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 20% ethyl acetate-dichloromethane) afforded ethyl Boc-L-hydroxyproline (193.7 g, 100%) as a yellow oil. Mass spectrum (M + Na): m/e 282. 1H-NMR (CDCl3) δ 1.30 (t, 3H), 1.45 (s, 9H), 1.75 (m, 1H), 2.10 (m, 1H), 2.30 (m, 1H), 3.45 and 3.55 (d, 1H, two rotary isomers), 3.65 (dd, 1H), 4.25 (m, 2H ), 4.40 and 4.45 (t, 1H, two rotary isomers), 4.55 (broad s, 1H).

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Boc-Hyp-Oet 37813-30-2
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-05
Career Henan Chemical Co
Product
1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester 37813-30-2
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

37813-30-2, 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Related Search:

Boc-L-beta-Homoproline N-Boc-D-alaninol Boc-O-benzyl-L-tyrosine N-Boc-cis-4-Hydroxy-L-proline methyl ester Boc-Hyp-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester BOC-L-TRANSPRO(OTS)-OBN BOC-HYP-OTBU BOC-HYP-OBZL 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

  • 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
  • 1-Boc-4-Hydroxy-L-Proline Ethyl Ester
  • 1-tert-butyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
  • (2S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-ethyl ester
  • (2S,4R)-1-BOC-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER
  • Boc-L-Hydroxy-Proline Ethyl Ester
  • (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester
  • 1-Boc-L-hydroxyproline ethyl ester
  • (2S-trans)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-ethyl ester
  • 1-tert-Butoxycarbonyl-4R-hydroxy-L-proline ethyl ester
  • (2S,4R)-1-tert-Butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • 37813-30-2)
  • (2S)-1-tert-butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • (4R)-1-Boc-4-hydroxy-L-proline ethyl ester
  • Boc-L-Hyp-oet
  • (Tert-Butoxy)Carbonyl Hyp-OEt (Syrup)
  • (2S,4R)-1-BOC-4-HYDROXYPYRROLININE-2-CARBOXYLIC ACID ETHYL ESTER
  • 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S,4R)-
  • 1-(tert-butyl) 2-ethyl (2S)-4-hydroxypyrrolidine-1,2-dicarboxylate
  • 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester USP/EP/BP
  • O1-tert-butyl O2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
  • Ethyl (2S,4R)-1-Boc-4-Hydroxypyrrolidine-2-carboxylate
  • (2S,4R)-N-Boc-trans-4-hydroxy-L-proline ethyl ester
  • BOC-L-Proline Ethyl ester
  • 37813-30-2