ChemicalBook > CAS DataBase List > 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE

2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE

Uses

Product Name: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE
CAS No.: 49844-93-1
Chemical Name: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE
Synonyms: Pyrimidine, 2-chloro-4-(methylthio)-;2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE;2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE ISO 9001：2015 REACH;2-Chloro-4-(methylsulphanyl)pyrimidine, 2-Chloro-4-(methylsulphonyl)-1,3-diazine
CBNumber: CB41010051
Molecular Formula: C5H5ClN2S
Formula Weight: 160.62
MOL File: 49844-93-1.mol

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2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE Property

Melting point:: 67-68 °C
Boiling point:: 125-126 °C(Press: 15 Torr)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -0.45±0.20(Predicted)
color: white

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C993408
Product name: 2-Chloro-4-(methylthio)pyrimidine
Packaging: 1g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-X3
Product name: 2-Chloro-4-(methylthio)pyrimidine
Packaging: 250mg
Price: $29
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11584
Product name: 2-Chloro-4-(methylthio)pyrimidine
Purity: 94%
Packaging: 1g
Price: $35
Updated: 2021/12/16

Matrix Scientific

Product number: 069579
Product name: 2-Chloro-4-methylthiopyrimidine
Purity: 96%
Packaging: 500mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC142921
Product name: 2-Chloro-4-(methylthio)pyrimidine
Packaging: 250mg
Price: $57.5
Updated: 2021/12/16

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2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE Chemical Properties,Usage,Production

Uses

2-Chloro-4-methylthiopyrimidine can be used as a pharmaceutical synthesis intermediate.

Synthesis

3934-20-1

5188-07-8

49844-93-1

At -10 °C, 2,4-dichloropyrimidine (20.0 g, 0.13 mol) was dissolved in 150 mL of anhydrous tetrahydrofuran, and sodium methanethiol (49.30 mL, 0.15 mol) was added slowly. The reaction mixture was gradually warmed up to room temperature with continuous stirring for 5 h, during which the reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS) or thin-layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed twice with saturated saline (x2). The organic layers were combined, dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The resulting solid was recrystallized with ether and collected by filtration to afford the target product 2-chloro-4-methylthiopyrimidine (Intermediate 10) as a white solid (11.2 g, 52% yield).

References

[1] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 967 - 971
[2] Organic Letters, 2016, vol. 18, # 9, p. 2180 - 2183
[3] Patent: WO2013/109882, 2013, A1. Location in patent: Page/Page column 63
[4] Patent: US2016/83365, 2016, A1. Location in patent: Paragraph 0841-0843
[5] Journal of Organic Chemistry, 2017, vol. 82, # 5, p. 2664 - 2671

2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE Suppliers

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View Lastest Price from 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE manufacturers

Dideu Industries Group Limited

Product: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE 49844-93-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-15

Career Henan Chemical Co

Product: 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE 49844-93-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

49844-93-1, 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINERelated Search:

4-Amino-6-chloro-2-(methylthio)pyrimidine 4,6-Dichloro-2-(methylthio)pyrimidine 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97% 4-CHLORO-6-METHYLTHIOPYRIMIDINE 4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE 2-CHLORO-4-THIOCYANATOPYRIMIDINE 5-BROMO-2-CHLORO-4-(METHYLTHIO)PYRIMIDINE 6-chloro-5-methylsulfanyl-pyrimidine-2,4-diamine methyl 6-chloro-2-methylsulfanyl-pyrimidine-4-carboxylate 4-AMINO-6-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-{4-[bis(4-fluorophenyl)methyl]-1-piperazinyl}-6-chloro-2-(methylsulfanyl)pyrimidine 2-[(2-CHLORO-4-PYRIMIDINYL)SULFANYL]-5-NITRO-1H-BENZIMIDAZOLE SALOR-INT L255475-1EA

2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE

2-Chloro-4-(methylsulphanyl)pyrimidine, 2-Chloro-4-(methylsulphonyl)-1,3-diazine

Pyrimidine, 2-chloro-4-(methylthio)-

2-CHLORO-4-METHYLSULFANYL-PYRIMIDINE ISO 9001：2015 REACH

49844-93-1

C5H5N2ClS

Building Blocks

Pyrimidine

Heterocycle-Pyrimidine series