ChemicalBook > CAS DataBase List > 4-(Boc-Aminomethyl)piperidine

4-(Boc-Aminomethyl)piperidine

Product Name
4-(Boc-Aminomethyl)piperidine
CAS No.
135632-53-0
Chemical Name
4-(Boc-Aminomethyl)piperidine
Synonyms
TERT-BUTYL (PIPERIDIN-4-YLMETHYL)CARBAMATE;tert-Butyl N-(piperidin-4-ylmethyl)carbamate;PIP(4-BOC-AM);BUTTPARK 43\57-92;(BOC-4-AMINOMETHYL)PIPERIDINE;4-(BOC-AMINOMETHYL)PIPERIDINE;4-N-BOC-AMINOMETHYL PIPERIDINE;4-(2-BOC-AMINOMETHYL) PIPERIDINE;me: 4-(Boc-Aminomethyl)piperidine;4-(Boc-aminomethyl)piperidine,97%
CBNumber
CB4102632
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
135632-53-0.mol
More
Less

4-(Boc-Aminomethyl)piperidine Property

Melting point:
106 °C
Boiling point:
321.8±15.0 °C(Predicted)
Density 
0.981±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO.
pka
12.72±0.46(Predicted)
form 
powder to crystal
color 
White to Almost white
CAS DataBase Reference
135632-53-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/38
Safety Statements 
26-36/37/39-45
RIDADR 
3259
Hazard Note 
Corrosive
HazardClass 
IRRITANT
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B4444
Product name
4-(tert-Butoxycarbonylaminomethyl)piperidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$344
Updated
2025/07/31
TRC
Product number
B701450
Product name
tert-Butyl(Piperidin-4-ylmethyl)carbamate
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
016373
Product name
tert-Butyl (piperidin-4-ylmethyl)carbamate
Purity
95+%
Packaging
5g
Price
$48
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB36900
Product name
4-(N-Boc-aminomethyl)piperidine
Packaging
2g
Price
$50
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK989088
Product name
4-(Boc-aminomethyl)piperidine
Purity
97%
Packaging
1g
Price
$67
Updated
2021/12/16
More
Less

4-(Boc-Aminomethyl)piperidine Chemical Properties,Usage,Production

Chemical Properties

4-Boc-aminomethylpiperidine contains a piperidine ring and an aminomethyl group, and the aminomethyl group is protected by a tert-butoxycarbonyl (Boc) group. This compound is commonly used as an intermediate in organic synthesis. The Boc protecting group is a common protecting group that protects the amine group in organic synthesis reactions. By adding the Boc protecting group, the amine group can be prevented from unwanted reactions while allowing other chemical reactions to take place. The tert-butoxycarbonyl protecting group can be removed under appropriate conditions before the amine group needs to be reduced.

Uses

4-(Boc-aminomethyl)piperidine is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

7144-05-0

49761-82-2

135632-53-0

General procedure: 4-aminomethylpiperidine (3.6 g) and 1-BOC-imidazole (5.3 g) were dissolved in toluene (80 mL), and the reaction was stirred at 25°C overnight. After completion of the reaction, the solution was concentrated and the residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/2) to afford Intermediate 227-I (4.7 g) in 70% yield. Intermediate 227-I (4.7 g) and triethylamine (2.7 mL) were dissolved in 1-pentanol (20 mL), 2,4-dichloro-6-aminopyrimidine (5.4 g) was added, and the reaction was carried out at 120 °C for 12 hours. After completion of the reaction, the solvent was removed and the residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/9) to afford Intermediate 227-II (5.2 g) in 70% yield. Intermediate 227-II (1.0 g) was treated with 1 M HCl (20 mL) in CH2Cl2 (10 mL) and stirred at room temperature for 8 hours. After completion of the reaction, the solution was concentrated, the residue neutralized with NH4OH and extracted with CH2Cl2. The organic layer was separated and concentrated, and the residue was purified by silica gel column chromatography (eluent: MeOH) to afford Intermediate 227-III (636 mg) in 90% yield. Intermediate 222-III (790 mg) was added to a solution of intermediate 227-III (450 mg) in MeOH (20 mL) and stirred at 25 °C for 2 hours. Then NaBH(OAc)3 (2.0 g) was added and the reaction was continued at 25 °C for 12 hours. After completion of the reaction, the solution was concentrated, saturated NaHCO3 solution was added and extracted with CH2Cl2. The organic layer was separated and concentrated, and the residue was purified by silica gel column chromatography (eluent: MeOH) to afford intermediate 227-IV (539 mg) in 60% yield. N1-morpholino-N1-piperazine ethane (240 mg) was added to a 1-pentanol (1 mL) solution of Intermediate 227-IV (160 mg) and stirred at 120 °C for 8 hours. After completion of the reaction, the solution was concentrated and the residue was purified by silica gel column chromatography (eluent: EtOAc/MeOH=5/1) to afford Intermediate 227-V (85 mg) in 40% yield. 20% TFA/CH2Cl2 (1 mL) was added to a solution of CH2Cl2 (1 mL) of intermediate 227-V (85 mg) and stirred at room temperature for 8 hours. After completion of the reaction, the solvent was removed and the residue was purified by silica gel column chromatography (eluent: 21% NH3(aq)/MeOH=1/19) to afford compound 227 (65 mg) in 90% yield. Finally, compound 227 was treated with a solution of CH2Cl2 (1 mL) in 1M HCl (1 mL) for 0.5 hours. After removal of the solvent, the residue was treated with ether and filtered to give the hydrochloride salt of compound 227.CI-MS (M++1): 544.4.

References

[1] Patent: US2006/281712, 2006, A1. Location in patent: Page/Page column 108-109

4-(Boc-Aminomethyl)piperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Di-tert-butyl dicarbonate Palladium Benzyl bromide Tetrahydrofuran Lithium Aluminum Hydride Isonipecotic acid Benzyl chloroformate Methanol

Preparation Products

More
Less

4-(Boc-Aminomethyl)piperidine Suppliers

Americas 1 Belgium 1 China 183 Europe 3 France 3 Germany 4 India 3 Japan 3 Switzerland 2 Ukraine 1 United Kingdom 14 United States 46 Global 264
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
BroadPharm. Inc.
Tel
--
Fax
--
Email
sales@broadpharm.com
Country
United States
ProdList
891
Advantage
50
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
RnD SciChem, LLC
Tel
--
Fax
--
Email
rndscichem@gmail.com
Country
United States
ProdList
569
Advantage
0
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
990
Advantage
50
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
CNH Technologies, Inc.
Tel
--
Fax
--
Email
info@cnhtechnologies.com
Country
United States
ProdList
353
Advantage
42
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Amber MolTech LLC.
Tel
--
Fax
--
Email
Info@ambermoltech.com
Country
United States
ProdList
58
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Syntech Development Company
Tel
--
Fax
--
Email
syntechsales@ureach.com
Country
United States
ProdList
162
Advantage
30
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
AQCHEM, LLC
Tel
--
Fax
--
Email
sales@aqchem.com
Country
United States
ProdList
491
Advantage
43
Biofine International Inc.
Tel
--
Fax
--
Email
sales@biofineintl.com
Country
United States
ProdList
653
Advantage
38
Anichem LLC
Tel
--
Fax
--
Email
sales@anichemllc.com
Country
United States
ProdList
4112
Advantage
34
Atlantic SciTech Group, Inc.
Tel
--
Fax
--
Email
sales@astginc.com
Country
United States
ProdList
2308
Advantage
43
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
1218
Advantage
30
EJY Tech, Inc.
Tel
--
Fax
--
Country
United States
ProdList
448
Advantage
30
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Rintech, Inc.
Tel
--
Fax
--
Email
info@rintechinc.com
Country
United States
ProdList
3416
Advantage
60
More
Less

View Lastest Price from 4-(Boc-Aminomethyl)piperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-(Boc-Aminomethyl)piperidine 135632-53-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-22
Honest Joy Holdings Limited
Product
4-(Boc-Aminomethyl)piperidine 135632-53-0
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-01-25
Career Henan Chemical Co
Product
me: 4-(Boc-Aminomethyl)piperidine 135632-53-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg; 2kg；10kg; 100kg
Release date
2019-08-30

135632-53-0, 4-(Boc-Aminomethyl)piperidineRelated Search:

2,2,6,6-Tetramethyl-4-piperidinol 2,2,6,6-Tetramethylpiperidinooxy 4-Aminobenzoic acid tert-Butanol 2-Butoxyethanol tert-Butyl carbamate Diethylene glycol monobutyl ether Urethane Buprofezin Hexamethyldisilazane tert-Butyl acetate tert-Butyl peroxybenzoate tert-Butyl peroxyacetate Methyl anthranilate 2-Amino-2-methyl-1-propanol Haloperidol 4-(Aminomethyl)piperidine tert-Butyl 4-aminobenzoate

  • 4-(2-BOC-AMINOMETHYL) PIPERIDINE
  • 4-AMINOMETHYLPIPERIDINE, BOC PROTECTED
  • 4-(BOC-AMINOMETHYL)PIPERIDINE
  • 4-N-BOC-AMINOMETHYL PIPERIDINE
  • 4-(TERT-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE
  • 4-(TERT-BUTOXYCARBONYLAMINOMETHYL)PIPERIDINE
  • 4-(T-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE
  • BUTTPARK 43\57-92
  • (BOC-4-AMINOMETHYL)PIPERIDINE
  • 4-(Aminomethyl)piperidine, 4-BOC protected
  • PIPERIDIN-4-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
  • PIP(4-BOC-AM)
  • TERT-BUTYL N-(4-PIPERIDINYLMETHYL)CARBAMATE
  • tert-butyl n-(4-piperidylmethyl)carbamate
  • TERT-BUTYL (PIPERIDIN-4-YLMETHYL)CARBAMATE
  • me: 4-(Boc-Aminomethyl)piperidine
  • 4-(Aminomethyl)piperidine, 4-BOC protected 95%
  • (BOC-4-aminomethyl)piperidine, min. 95 %
  • Carbamic acid, (4-piperidinylmethyl)-, 1,1-dimethylethyl ester
  • tert-butyl (piperidin-4-ylmethyl)carbamate(SALTDATA: HCl)
  • 4-(Boc-aminomethyl)-piperidine hydrochloride
  • tert-butyl piperidin-4-ylmethylcarbamate hydrochloride
  • 1,1-diMethylethyl [(piperidin-4-yl)Methyl]carbaMate
  • tert-Butyl [(piperidin-4-yl)methyl]carbamate, 4-{[(tert-Butoxycarbonyl)amino]methyl}piperidine
  • 4-(Boc-aminomethyl)piperidine,97%
  • Carbamic acid, N-(4-piperidinylmethyl)-, 1,1-dimethylethyl ester
  • tert-Butyl N-(piperidin-4-ylmethyl)carbamate
  • (4-Piperidylmethyl)carbamic Acid tert-Butyl Ester
  • tert-Butyl (4-Piperidylmethyl)carbamate
  • 5,7-diethyl-2-(3-nitrophenyl)-1,3-diazaadamantan-11-one
  • 4-(Boc-aminomethyl)piperidine - [A12321]
  • 135632-53-0
  • Pyrans, Piperidines & Piperazines
  • pharmacetical
  • Aminomethyl's
  • Pyrans, Piperidines &Piperazines
  • Piperidine