ChemicalBook > CAS DataBase List > (S)-2-Methyl-morpholine

(S)-2-Methyl-morpholine

Product Name
(S)-2-Methyl-morpholine
CAS No.
74572-13-7
Chemical Name
(S)-2-Methyl-morpholine
Synonyms
(2S)-2-MethylMorpholine;(S)-2-Methyl-morpholine;(S)-2-Methylmorpholine HCl;Morpholine, 2-Methyl-, (S)-;(S)-2-Methyl-morpholine 95+;Morpholine, 2-methyl-, (2S)-;(S)-2-methylmorpholine Molecular Weight: 101.15
CBNumber
CB41041037
Molecular Formula
C5H11NO
Formula Weight
101.15
MOL File
74572-13-7.mol
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(S)-2-Methyl-morpholine Property

Boiling point:
137℃
Density 
0.891
Flash point:
41℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
9.01±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
optical activity
Consistent with structure
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Safety

RIDADR 
1993
HazardClass 
3
PackingGroup 
Ⅲ
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M271915
Product name
(S)-2-Methylmorpholine
Packaging
1g
Price
$725
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
47342
Product name
(S)-2-Methylmorpholine
Packaging
1g
Price
$1160
Updated
2021/12/16
Activate Scientific
Product number
AS31353-A
Product name
(S)-2-Methylmorpholine
Purity
95+% ee
Packaging
5G
Price
$1220
Updated
2021/12/16
Activate Scientific
Product number
AS31353-A
Product name
(S)-2-Methylmorpholine
Purity
95+% ee
Packaging
1g
Price
$389
Updated
2021/12/16
SynQuest Laboratories
Product number
4H44-1-45
Product name
(2S)-2-Methylmorpholine
Packaging
250mg
Price
$400
Updated
2021/12/16
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(S)-2-Methyl-morpholine Chemical Properties,Usage,Production

Uses

(S)-2-Methylmorpholine is a reactant in the synthesis of imidazo[1,2-a]-pyrimidin-5(1H)-ones as PI3K-beta selective inhibitors.

Synthesis

74572-10-4

74572-13-7

General procedure for the synthesis of (S)-2-methylmorpholine from the compound (CAS: 74572-10-4): (2S)-2-methyl-4-(4-methylphenyl)sulfonylmorpholine (EE2, 13.26 g, 51.93 mmol), phenol (9.77 g, 103.86 mmol), and an acetic acid solution of 33% HBr (89 mL, 363.52 mmol) were mixed and stirred at room temperature for 6 hours. After completion of the reaction, the reaction mixture was evaporated to dryness. The crude product obtained was ground with ether (Et2O) to form a solid, which was collected by filtration and dried under vacuum to afford (2S)-2-methylmorpholine hydrobromide (6.77 g, 72% yield) as a white solid.1H NMR (400 MHz, DMSO) δ 1.18 (3H, d), 2.74 (1H, t), 3.01 (1H, td) 3.23 (1H, d), 3.26 (1H, d), 3.73 (1H, td), 3.79 (1H, dqd), 3.98 (1H, dd), 8.86 (2H, s).

References

[1] Patent: WO2010/136778, 2010, A1. Location in patent: Page/Page column 85
[2] Tetrahedron, 1980, vol. 36, p. 409 - 415

(S)-2-Methyl-morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-2-Methyl-morpholine manufacturers

Career Henan Chemical Co
Product
(S)-2-Methyl-morpholine 74572-13-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-01-02

74572-13-7, (S)-2-Methyl-morpholineRelated Search:

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  • (S)-2-Methyl-morpholine
  • (S)-2-Methylmorpholine HCl
  • Morpholine, 2-Methyl-, (S)-
  • (2S)-2-MethylMorpholine
  • Morpholine, 2-methyl-, (2S)-
  • (S)-2-methylmorpholine Molecular Weight: 101.15
  • (S)-2-Methyl-morpholine 95+
  • 74572-13-7