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Dexamethasone palmitate

Product Name
Dexamethasone palmitate
CAS No.
14899-36-6
Chemical Name
Dexamethasone palmitate
Synonyms
D01615;Lipotalon;Limethason;Limethasone;Limethason (tn);DXM-21-palmitate;DEXAMETHASOME PALMITATE;Dexamethasone palmitate;Dexamethasone-21-palmitate;Dexamethasone palmitate (jan)
CBNumber
CB41074390
Molecular Formula
C38H59FO6
Formula Weight
630.87
MOL File
14899-36-6.mol
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Dexamethasone palmitate Property

Melting point:
60-65 °C
Boiling point:
710.1±60.0 °C(Predicted)
Density 
1.12
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
11.99±0.70(Predicted)
color 
White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D298830
Product name
Dexamethasone21-Palmitate
Packaging
250mg
Price
$480
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21400
Product name
Dexamethasone 21-palmitate
Packaging
250mg
Price
$700
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012845
Product name
DEXAMETHASONE PALMITATE
Purity
95.00%
Packaging
100MG
Price
$721.88
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21400
Product name
Dexamethasone 21-palmitate
Packaging
500mg
Price
$1200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012845
Product name
DEXAMETHASONE PALMITATE
Purity
95.00%
Packaging
1G
Price
$1732.5
Updated
2021/12/16
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Dexamethasone palmitate Chemical Properties,Usage,Production

Description

Dexamethasone palmitate (DXP) is a prodrug of dexamethasone,which is a steroidal antinflammatory drug that is used to treat certain pain and inflammatory conditions such as asthma and rheumatoid arthritis. This prodrug was prepared to increase the distribution of the parent drug, dexamethasone, in the lungs for local drug delivery and to prevent its entry into the systemic circulation. This prodrug was developed as a powder formulation that needs to be administered via the pulmonary route so that it can easily reach into the lungs and show its effect locally.Normal delivery of dexamethasone enters systemic circulation very easily but this palmitate prodrug cannot easily enter into the systemic circula-tion. Within the lungs, the prodrug is acted upon by esterase enzyme that brings about hydrolysis,leading to the release of parent drug and increases the distribution of parentdrug inside the lungs (N'Guessan et al.,2018).

Chemical Properties

Colourless Thick Oil

Uses

A corticosteroid prodrug for the treatment of eye disorders.

Definition

ChEBI: Dexamethasone palmitate is an organic molecular entity.

Biochem/physiol Actions

Dexamethasone Palmitate is a lipophilic prodrug of a potent corticosteroid dexamethasone that is quickly taking up by macrophages via phagocytosis. Dexamethasone Palmitate inhibits function and migration of leukocytes and tissue macrophages.

Dexamethasone palmitate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dexamethasone palmitate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Dexamethasone palmitate 14899-36-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27
Hubei Harvest Chemical CO.,Ltd
Product
Dexamethasone palmitate 14899-36-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000000000
Release date
2022-12-23
Career Henan Chemical Co
Product
Dexamethasone palmitate 14899-36-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-25

14899-36-6, Dexamethasone palmitateRelated Search:

Palmitic acid 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Dexamethasone-17-acetate Dexamethasone sodium phosphate Ascorbyl Palmitate Dexamethasone Palmitic anhydride hexadecanal Dexamethasone 21-phosphate disodium salt 6-hydroxydexamethasone PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone 21-Propionate 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) 16-beta Methyl Epoxide 16α-Methyl-11-oxo Prednisolone (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione Dexamethasone-d5 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione

  • (11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-[(1-oxohexadecyl)oxy]pregna-1,4-diene-3,20-dione
  • DEXAMETHASOME PALMITATE
  • Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]-, (11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate (6CI, 8CI)
  • 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-palmitate
  • Dexamethasone palmitate
  • 21-(Palmitoyloxy)-9α-fluoro-11β,17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
  • D01615
  • Dexamethasone palmitate (jan)
  • Limethason (tn)
  • Dexamethasone Impurity 20（Dexamethasone Palmitate）
  • Dexamethasone Impurity 21（Dexamethasone Palmitate）
  • Dexamethasone-21-palmitate
  • DXM-21-palmitate
  • Limethason
  • Limethasone
  • Lipotalon
  • Dexamethasone palmitate (DXP)
  • 21-Dehydrodexamethasone Dihydrate
  • Dexamethasone Palmitate Corticosteroid Raw Powder
  • lipophilic,prodrug,RAW 264.7,VEGF,Dexamethasone palmitate,Dexamethasone,Inhibitor,inflammation,inhibit,cytokine
  • Dexamethasone Impurity 20 CRS（Dexamethasone Palmitate CRS）
  • 2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl Palmitate
  • 14899-36-6
  • C38H59FO6
  • Drug Analogues
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids