ChemicalBook > CAS DataBase List > Ribonuclease A

Ribonuclease A

Product Name: Ribonuclease A
CAS No.: 9001-99-4
Chemical Name: Ribonuclease A
Synonyms: RP-1;RNASE;RNAase;S-RNase;Rnase I;RNASE A;abs9330;RNAase A;Amphinase;DNase-free
CBNumber: CB4131184
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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Ribonuclease A Property

Melting point:: 243 °C (dec.)
alpha: D25 (per mg N) -0.47° (c = 5)
storage temp.: -20°C
solubility: Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calcium chloride
form: solid
color: white
PH: pH : 8.0
biological source: protein from bovine pancreas
Water Solubility: Soluble in water.
Sensitive: Moisture Sensitive
Specific Activity: 85-140Kunitz units/mg protein
EPA Substance Registry System: Nuclease, ribo- (9001-99-4)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: RF0760000
F: 10-21
TSCA: Yes
HS Code: 35079090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: RNASEA-RO
Product name: RNase A
Purity: from bovine pancreas
Packaging: 25mg
Price: $60.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: RNASEA-RO
Product name: RNase A
Purity: from bovine pancreas
Packaging: 100mg
Price: $129
Updated: 2025/07/31

Sigma-Aldrich

Product number: R7884
Product name: Ribonuclease B from bovine pancreas
Purity: BioReagent,≥50?Kunitzunits/mgprotein,≥80%(SDS-PAGE)
Packaging: 500μg
Price: $50.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: R1153
Product name: RNase B Glycoprotein Standard from bovine pancreas
Purity: Proteomics Grade
Packaging: 500μg
Price: $338.47
Updated: 2025/07/31

Sigma-Aldrich

Product number: 55674-M
Product name: RNaseA, Bovine Pancreas
Packaging: 1 unit
Price: $392
Updated: 2025/07/31

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Ribonuclease A Chemical Properties,Usage,Production

Chemical Properties

Lyophilized

Uses

Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas.

Uses

Ribonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA. Ribonuclease A from bovine pancreas has been used in a study to assess the mechanism of heavy metal ions on RNase activity. Ribonuclease A from bovine pancreas has also been used in a study to investigate the performance of oligomeric poly(diallyldimethylammonium chloride) as displacer for cation-exchange displacement chromatography of proteins.

General Description

Human chromosome 14q11.2 shows the presence of all human RNases. Only eight (RNase 1-8) of them were true called as canonical RNases. And the rest nine to thirteen are called as noncanonical RNases. Human RNase 1 is called as HP-RNase or human pancreatic RNase. Human RNase 2 is also called as EDN (eosinophils derived neurotoxin) that is isolated from eosinophils.

Biochem/physiol Actions

Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3′ phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts.

Purification Methods

Purify it by (NH4)2SO4 fractionation, followed by PC cellulose chromatography and affinity chromatography (using Sepharose 4B to which (G)n is covalently bonded). [Schmukler et al. J Biol Chem 250 2206 1975.] Ribozymes. These are ribonucleic acids which act like protein enzyme in catalyzing the making and breaking of peptide bonds as well as catalyzing reactions and cleavage of DNA and RNA molecules. The short RNAs are being intensively studied (see RNAi below). MicroRNAs (miRNA, see also below) are ubiquitous and are also genetically produced. They are involved in numerous reactions from splicing RNA, e.g. mRNA (messenger RNA) to controlling transcription of DNA to RNA, and translation of RNA to protein. Each miRNA is capable of being involved in a small number to hundreds of interactions with nucleic acids and with proteins.

Ribonuclease A Preparation Products And Raw materials

Raw materials

Erythromycin Ammonium sulfate

Preparation Products

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View Lastest Price from Ribonuclease A manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ribonuclease A 9001-99-4
Price: US $2.20-8.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ribonuclease A 9001-99-4
Price: US $1.00/g
Min. Order: 1g
Purity: ≥60u/mg
Supply Ability: 10kg/month
Release date: 2021-06-10

Jiangsu Boquan Biotechnology Co., Ltd.

Product: Ribonuclease A 9001-99-4
Price: US $88.00-81.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 10KG
Release date: 2023-02-21

9001-99-4, Ribonuclease ARelated Search:

Ribonucleic acid Phosphatase, Acid froM Wheat GerM EC 3.1.31.1 Nuclease, streptococcal deoxyribo- Alkaline Phosphatase RIBONUCLEASE H RIBONUCLEASE INHIBITOR DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Recombinant RNasin Tosylmethyl isocyanide METHYL ISOCYANOACETATE COBALT(II) ACETYLACETONATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) PHENYLSELENOL Benzyl isocyanide

Ribonuclease A froM bovine pancreas Min. 70 Kunitz units/Mg lyophil.

Ribonuclease A froM bovine pancreas Min. 80 Kunitz units/Mg lyophil.

Ribonuclease A froM bovine pancreas(Purified)

Ribonuclease A from bovine pancreas Vetec(TM) reagent grade, 80%

bonuclease A

O-PHENYLENEDIAMINE REAGENT GRADE

RIBONUCLEASE A FROM BOVINE PANCREAS, POW DER, ~80 U/MG

RIBONUCLEASE A SOLUTION MOLECULAR*BIOLOG Y REAGENT

RNASE A, BOVINE PANCREAS

RibonucleaseDExBovinePancreas

RibonucleaseExBovinePancreas

RibonucleaseAExBovinePancreas

DNase-free

Ribonuclease A from bovine pancreas ca. 70 Kunitz units/mg

Ribonuclease A from bovine pancreas ca. 90 Kunitz units/mg

ribonuclease s from bovine pancreas

rnase b glycoprotein standard from bovine pancreas

RNASEA,LYOPHILIZEDPOWDER,HIGHPURITY

RP-1

Amphinase

S-RNase

RNase A (from bovine pancreas)

RIBONUCLEASE extrapure

RibonucleaseA, with scrambled disulfide bonds from bovine pancreas

Ribonuclease A-agarose

Ribonuclease I, Ribonucleate 3μ-pyrimidinooligonucleotidohydrolase

Rnase I

ribornuclease

RNAase

RIBONUCLEASE A FROM BOVINEPANCREAS CA.90 KUNITZ-U/MG LYOPHIL.

RIBONUCLEASE A BOVINE PANCR.CA.70 KUNITZ-U/MG LYOPHIL.

RNase B Glycoprotein Standard from bovine pancreas,RNase B, Ribonuclease B from bovine pancreas

Ribonuclease A from bovine pancreas,Pancreatic Ribonuclease, RNase A, Ribonuclease I, Ribonucleate 3′-pyrimidinooligonucleotidohydrolase

Ribonuclease A, from bovine pancreas, 50 KU/mg

RIBONUCLEASE A FROM BOVINE PANCREAS, POW DER, ~100 U/MG

RIBONUCLEASE B PROTEOMICS GRADE

RIBONUCLEASE A TYPE X-A: SOLUTION FROM*B OVINE PANCR

RIBONUCLEASE A FROM BOVINE PANCREAS, IN 0.2 M SO-PHOSPHATE*

RIBONUCLEASE A FROM BOVINE PANCREAS, >70 U/MG*

RIBONUCLEASE A FROM BOVINE PANCREAS, TYPE 1-A

Ribonuclease A from bovine pancreas, lyophil.

ribonuclease A solution molecular*biology

ribonuclease A type I-A from*bovine pancreas

ribonuclease A type I-as from*bovine pancreas

ribonuclease A type ii-A from*bovine pancreas

ribonuclease A type iii-A from*bovine pancreas

ribonuclease A type X-A: solution from*bovine pan

ribonuclease A type xii-A from bovine*pancreas

Ribonuclease A, Protease-Free

ribonuclease from aspergillus clavatus

ribonuclease S grade xii-S

Nuclease, ribo-

RIBONUCLEASE A, CHROMATOGRAPHICALLY*PURI FIED, MOLEC

RIBONUCLEASE A FROM BOVINE PANCREAS 4XCR SALTFREE ~70 U/MG

RIBONUCLEASE A FROM BOVINE PANCREAS, ~90 U/MG

Ribonuclease B from bovine pancreas,RNase B

Ribonuclease from Bovine Pancreas

Ribonuclease A from bovine pancreas min. 80 Kunitz units/mg