1,4-BIS-MALEIMIDOBUTANE

Product Name: 1,4-BIS-MALEIMIDOBUTANE
CAS No.: 28537-70-4
Chemical Name: 1,4-BIS-MALEIMIDOBUTANE
Synonyms: BMB;NSC44747;BMB Crosslinker;Bis-MaleiMidobutane;1,4-BIS-MALEIMIDOBUTANE;1,4-DI(MALEIMIDO)BUTANE;1,4-BIS(MALEIMIDE)BUTANE;TetraMethylenediMaleiMide;TetraMethylenebisMaleiMide;1,4-Bis-MaleiMidobutane(BMB)
CBNumber: CB4131366
Molecular Formula: C12H12N2O4
Formula Weight: 248.23
MOL File: 28537-70-4.mol

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1,4-BIS-MALEIMIDOBUTANE Property

Melting point:: 196-197°C
Boiling point:: 450.3±28.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform
form: Solid
pka: -1.93±0.20(Predicted)
color: White to Off-White
Appearance: White solid
BRN: 1538100
InChI: InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChIKey: WXXSHAKLDCERGU-UHFFFAOYSA-N
SMILES: C(N1C(=O)C=CC1=O)CCCN1C(=O)C=CC1=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2922.49.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3805
Product name: 1,4-Bis(maleimido)butane
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $412
Updated: 2025/07/31

TCI Chemical

Product number: B3805
Product name: 1,4-Bis(maleimido)butane
Purity: >98.0%(HPLC)(N)
Packaging: 100mg
Price: $82
Updated: 2025/07/31

TRC

Product number: B475000
Product name: 1,4-Bis(maleimido)butane
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18729
Product name: 1,4-Bis(maleimido)butane
Packaging: 50mg
Price: $150.5
Updated: 2021/12/16

Chem-Impex

Product number: 23109
Product name: 1,4-Bis-maleimidobutane,≥99%(NMR)
Purity: ≥99%(NMR)
Packaging: 100MG
Price: $186.37
Updated: 2021/12/16

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1,4-BIS-MALEIMIDOBUTANE Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A short, sulfhydryl reactive homobifunctional crosslinking reagent

Synthesis

1449655-98-4

28537-70-4

General method: 1,4-bis(bromomethyl)benzene (1 mol) was dissolved in 1,1,2,2-tetrachloroethane in an open-ended flask with continuous stirring at 120°C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC). When the reaction was complete, the solvent was removed by evaporation under reduced pressure to give 1,4-bis(maleimido)butane (BMI).

References

[1] Tetrahedron Letters, 2013, vol. 54, # 37, p. 5011 - 5013

1,4-BIS-MALEIMIDOBUTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-BIS-MALEIMIDOBUTANE Suppliers

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28537-70-4, 1,4-BIS-MALEIMIDOBUTANERelated Search:

2-AMINOETHANETHIOL 1 4-DIMALEIMIDO-2 3-BUTANEDIOL 1,4-BIS-MALEIMIDOBUTANE 1,2-Bis(maleimido)ethane DITHIO-BIS-MALEIMIDOETHANE

N,N'-(1,4-Butanediyl)di(maleimide)

N,N'-Tetramethylenebis(maleimide)

1-(4-maleimidobutyl)-3-pyrroline-2,5-quinone

1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione

TetraMethylenebisMaleiMide

TetraMethylenediMaleiMide

1H-Pyrrole-2,5-dione, 1,1'-(1,4-butanediyl)bis-

1,4-Bis-MaleiMidobutane(BMB)

1,1'-(butane-1,4-diyl) bis(1H-pyrrole-2,5-dione)

Bis-MaleiMidobutane

N,N'-1,4-Butylenebismaleimide

1,4-BIS(MALEIMIDE)BUTANE

1,4-BIS-MALEIMIDOBUTANE

1,4-DI(MALEIMIDO)BUTANE

BMB

N,N'-(TETRAMETHYLENE)DIMALEIMIDE

NSC44747

1,4-Bis(maleimido)butane, BMB, N,Nμ-(Tetramethylene)dimaleimide

1,1'-(1,4-Butanediyl)bis(1H-pyrrole-2,5-dione)

1,1'-(1,4-Butanediyl)bis(3-pyrroline-2,5-dione)

1,4-Bis-maleimidobutane≥ 99% (NMR)

BMB (1,4-bismaleimidobutane)

1,4-Bis(maleimido)butane &gt

1,1'-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)

BMB Crosslinker

28537-70-4

Homobifunctional Crosslinker

pharmacetical

Maleimide Derivatives

Cross Linking Reagents

MTS & Sulfhydryl Active Reagents