ChemicalBook > CAS DataBase List > 1,4-BIS-MALEIMIDOBUTANE

1,4-BIS-MALEIMIDOBUTANE

Product Name
1,4-BIS-MALEIMIDOBUTANE
CAS No.
28537-70-4
Chemical Name
1,4-BIS-MALEIMIDOBUTANE
Synonyms
BMB;NSC44747;BMB Crosslinker;Bis-MaleiMidobutane;1,4-BIS-MALEIMIDOBUTANE;1,4-DI(MALEIMIDO)BUTANE;1,4-BIS(MALEIMIDE)BUTANE;TetraMethylenediMaleiMide;TetraMethylenebisMaleiMide;1,4-Bis-MaleiMidobutane(BMB)
CBNumber
CB4131366
Molecular Formula
C12H12N2O4
Formula Weight
248.23
MOL File
28537-70-4.mol
More
Less

1,4-BIS-MALEIMIDOBUTANE Property

Melting point:
196-197°C
Boiling point:
450.3±28.0 °C(Predicted)
Density 
1.388±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform
form 
Solid
pka
-1.93±0.20(Predicted)
color 
White to Off-White
Appearance
White solid
BRN 
1538100
InChI
InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChIKey
WXXSHAKLDCERGU-UHFFFAOYSA-N
SMILES
C(N1C(=O)C=CC1=O)CCCN1C(=O)C=CC1=O
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2922.49.8000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B3805
Product name
1,4-Bis(maleimido)butane
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$412
Updated
2025/07/31
TCI Chemical
Product number
B3805
Product name
1,4-Bis(maleimido)butane
Purity
>98.0%(HPLC)(N)
Packaging
100mg
Price
$82
Updated
2025/07/31
TRC
Product number
B475000
Product name
1,4-Bis(maleimido)butane
Packaging
100mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18729
Product name
1,4-Bis(maleimido)butane
Packaging
50mg
Price
$150.5
Updated
2021/12/16
Chem-Impex
Product number
23109
Product name
1,4-Bis-maleimidobutane,≥99%(NMR)
Purity
≥99%(NMR)
Packaging
100MG
Price
$186.37
Updated
2021/12/16
More
Less

1,4-BIS-MALEIMIDOBUTANE Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A short, sulfhydryl reactive homobifunctional crosslinking reagent

Synthesis

1449655-98-4

28537-70-4

General method: 1,4-bis(bromomethyl)benzene (1 mol) was dissolved in 1,1,2,2-tetrachloroethane in an open-ended flask with continuous stirring at 120°C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC). When the reaction was complete, the solvent was removed by evaporation under reduced pressure to give 1,4-bis(maleimido)butane (BMI).

References

[1] Tetrahedron Letters, 2013, vol. 54, # 37, p. 5011 - 5013

1,4-BIS-MALEIMIDOBUTANE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,4-BIS-MALEIMIDOBUTANE Suppliers

Americas 1 Canada 1 China 57 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 88
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91

28537-70-4, 1,4-BIS-MALEIMIDOBUTANERelated Search:

2-AMINOETHANETHIOL 1 4-DIMALEIMIDO-2 3-BUTANEDIOL 1,4-BIS-MALEIMIDOBUTANE 1,2-Bis(maleimido)ethane DITHIO-BIS-MALEIMIDOETHANE

  • N,N'-(1,4-Butanediyl)di(maleimide)
  • N,N'-Tetramethylenebis(maleimide)
  • 1-(4-maleimidobutyl)-3-pyrroline-2,5-quinone
  • 1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione
  • TetraMethylenebisMaleiMide
  • TetraMethylenediMaleiMide
  • 1H-Pyrrole-2,5-dione, 1,1'-(1,4-butanediyl)bis-
  • 1,4-Bis-MaleiMidobutane(BMB)
  • 1,1'-(butane-1,4-diyl) bis(1H-pyrrole-2,5-dione)
  • Bis-MaleiMidobutane
  • N,N'-1,4-Butylenebismaleimide
  • 1,4-BIS(MALEIMIDE)BUTANE
  • 1,4-BIS-MALEIMIDOBUTANE
  • 1,4-DI(MALEIMIDO)BUTANE
  • BMB
  • N,N'-(TETRAMETHYLENE)DIMALEIMIDE
  • NSC44747
  • 1,4-Bis(maleimido)butane, BMB, N,Nμ-(Tetramethylene)dimaleimide
  • 1,1'-(1,4-Butanediyl)bis(1H-pyrrole-2,5-dione)
  • 1,1'-(1,4-Butanediyl)bis(3-pyrroline-2,5-dione)
  • 1,4-Bis-maleimidobutane≥ 99% (NMR)
  • BMB (1,4-bismaleimidobutane)
  • 1,4-Bis(maleimido)butane &gt
  • 1,1'-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)
  • BMB Crosslinker
  • 28537-70-4
  • Homobifunctional Crosslinker
  • pharmacetical
  • Maleimide Derivatives
  • Cross Linking Reagents
  • MTS & Sulfhydryl Active Reagents