ChemicalBook > CAS DataBase List > 1,4-BIS-MALEIMIDOBUTANE

1,4-BIS-MALEIMIDOBUTANE

Product Name: 1,4-BIS-MALEIMIDOBUTANE
CAS No.: 28537-70-4
Chemical Name: 1,4-BIS-MALEIMIDOBUTANE
Synonyms: BMB;NSC44747;BMB Crosslinker;Bis-MaleiMidobutane;1,4-BIS-MALEIMIDOBUTANE;1,4-DI(MALEIMIDO)BUTANE;1,4-BIS(MALEIMIDE)BUTANE;TetraMethylenediMaleiMide;TetraMethylenebisMaleiMide;1,4-Bis-MaleiMidobutane(BMB)
CBNumber: CB4131366
Molecular Formula: C12H12N2O4
Formula Weight: 248.23
MOL File: 28537-70-4.mol

Less

1,4-BIS-MALEIMIDOBUTANE Property

Melting point:: 196-197°C
Boiling point:: 450.3±28.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform
form: Solid
pka: -1.93±0.20(Predicted)
color: White to Off-White
Appearance: White solid
BRN: 1538100
InChI: InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChIKey: WXXSHAKLDCERGU-UHFFFAOYSA-N
SMILES: C(N1C(=O)C=CC1=O)CCCN1C(=O)C=CC1=O

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2922.49.8000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3805
Product name: 1,4-Bis(maleimido)butane
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $412
Updated: 2025/07/31

TCI Chemical

Product number: B3805
Product name: 1,4-Bis(maleimido)butane
Purity: >98.0%(HPLC)(N)
Packaging: 100mg
Price: $82
Updated: 2025/07/31

TRC

Product number: B475000
Product name: 1,4-Bis(maleimido)butane
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18729
Product name: 1,4-Bis(maleimido)butane
Packaging: 50mg
Price: $150.5
Updated: 2021/12/16

Chem-Impex

Product number: 23109
Product name: 1,4-Bis-maleimidobutane,≥99%(NMR)
Purity: ≥99%(NMR)
Packaging: 100MG
Price: $186.37
Updated: 2021/12/16

Less

1,4-BIS-MALEIMIDOBUTANE Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A short, sulfhydryl reactive homobifunctional crosslinking reagent

Synthesis

1449655-98-4

28537-70-4

General method: 1,4-bis(bromomethyl)benzene (1 mol) was dissolved in 1,1,2,2-tetrachloroethane in an open-ended flask with continuous stirring at 120°C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC). When the reaction was complete, the solvent was removed by evaporation under reduced pressure to give 1,4-bis(maleimido)butane (BMI).

References

[1] Tetrahedron Letters, 2013, vol. 54, # 37, p. 5011 - 5013

1,4-BIS-MALEIMIDOBUTANE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1,4-BIS-MALEIMIDOBUTANE Suppliers

Americas 1 Canada 1 China 57 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 88

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: ET-market@chemextension.com
Country: China
ProdList: 4673
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Dalian lichuang Chemical Co., Ltd

Tel: 0411-0411-00000000 13644282108
Fax: -
Email: 3500508746@qq.com
Country: China
ProdList: 2896
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd

Tel: +86-13522808617
Email: omichem@126.com
Country: China
ProdList: 6413
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9948
Advantage: 58

Block Chemical Technology (Shanghai) Co., Ltd.

Tel: 021-20432219 13918097649
Fax: QQ79021576
Email: li_jinfei@acblock-lab.com
Country: China
ProdList: 11318
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shanghai Lumeng Technology Co., LTD

Tel: 18049902746
Email: sales@loomatel.com
Country: China
ProdList: 169
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8887
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Henan Dowon Chemical Technology Co., Ltd.

Tel: 16696119288
Email: 779113375@qq.com
Country: China
ProdList: 7236
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Jinshine Biochem Technology Co., Ltd

Tel: 189-1821-4718 18918214718
Email: sales@jinshinechem.com
Country: China
ProdList: 171
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: +undefined18143011203
Email: info@chemextension.com
Country: China
ProdList: 42056
Advantage: 58

Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 127
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Rhenbo (Shanghai) Biochemical Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6333
Advantage: 58

Shanghai Qincheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shqcsw01@163.com
Country: CHINA
ProdList: 6821
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6448
Advantage: 58

28537-70-4, 1,4-BIS-MALEIMIDOBUTANERelated Search:

2-AMINOETHANETHIOL 1 4-DIMALEIMIDO-2 3-BUTANEDIOL 1,4-BIS-MALEIMIDOBUTANE 1,2-Bis(maleimido)ethane DITHIO-BIS-MALEIMIDOETHANE

N,N'-(1,4-Butanediyl)di(maleimide)

N,N'-Tetramethylenebis(maleimide)

1-(4-maleimidobutyl)-3-pyrroline-2,5-quinone

1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione

TetraMethylenebisMaleiMide

TetraMethylenediMaleiMide

1H-Pyrrole-2,5-dione, 1,1'-(1,4-butanediyl)bis-

1,4-Bis-MaleiMidobutane(BMB)

1,1'-(butane-1,4-diyl) bis(1H-pyrrole-2,5-dione)

Bis-MaleiMidobutane

N,N'-1,4-Butylenebismaleimide

1,4-BIS(MALEIMIDE)BUTANE

1,4-BIS-MALEIMIDOBUTANE

1,4-DI(MALEIMIDO)BUTANE

BMB

N,N'-(TETRAMETHYLENE)DIMALEIMIDE

NSC44747

1,4-Bis(maleimido)butane, BMB, N,Nμ-(Tetramethylene)dimaleimide

1,1'-(1,4-Butanediyl)bis(1H-pyrrole-2,5-dione)

1,1'-(1,4-Butanediyl)bis(3-pyrroline-2,5-dione)

1,4-Bis-maleimidobutane≥ 99% (NMR)

BMB (1,4-bismaleimidobutane)

1,4-Bis(maleimido)butane &gt

1,1'-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)

BMB Crosslinker

28537-70-4

Homobifunctional Crosslinker

pharmacetical

Maleimide Derivatives

Cross Linking Reagents

MTS & Sulfhydryl Active Reagents