ChemicalBook > CAS DataBase List > 1,4-BIS-MALEIMIDOBUTANE

1,4-BIS-MALEIMIDOBUTANE

Product Name
1,4-BIS-MALEIMIDOBUTANE
CAS No.
28537-70-4
Chemical Name
1,4-BIS-MALEIMIDOBUTANE
Synonyms
BMB;NSC44747;BMB Crosslinker;Bis-MaleiMidobutane;1,4-BIS-MALEIMIDOBUTANE;1,4-DI(MALEIMIDO)BUTANE;1,4-BIS(MALEIMIDE)BUTANE;TetraMethylenediMaleiMide;TetraMethylenebisMaleiMide;1,4-Bis-MaleiMidobutane(BMB)
CBNumber
CB4131366
Molecular Formula
C12H12N2O4
Formula Weight
248.23
MOL File
28537-70-4.mol
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1,4-BIS-MALEIMIDOBUTANE Property

Melting point:
196-197°C
Boiling point:
450.3±28.0 °C(Predicted)
Density 
1.388±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform
form 
Solid
pka
-1.93±0.20(Predicted)
color 
White to Off-White
Appearance
White solid
BRN 
1538100
InChI
InChI=1S/C12H12N2O4/c15-9-3-4-10(16)13(9)7-1-2-8-14-11(17)5-6-12(14)18/h3-6H,1-2,7-8H2
InChIKey
WXXSHAKLDCERGU-UHFFFAOYSA-N
SMILES
C(N1C(=O)C=CC1=O)CCCN1C(=O)C=CC1=O
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2922.49.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3805
Product name
1,4-Bis(maleimido)butane
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$412
Updated
2025/07/31
TCI Chemical
Product number
B3805
Product name
1,4-Bis(maleimido)butane
Purity
>98.0%(HPLC)(N)
Packaging
100mg
Price
$82
Updated
2025/07/31
TRC
Product number
B475000
Product name
1,4-Bis(maleimido)butane
Packaging
100mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18729
Product name
1,4-Bis(maleimido)butane
Packaging
50mg
Price
$150.5
Updated
2021/12/16
Chem-Impex
Product number
23109
Product name
1,4-Bis-maleimidobutane,≥99%(NMR)
Purity
≥99%(NMR)
Packaging
100MG
Price
$186.37
Updated
2021/12/16
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1,4-BIS-MALEIMIDOBUTANE Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

A short, sulfhydryl reactive homobifunctional crosslinking reagent

Synthesis

1449655-98-4

28537-70-4

General method: 1,4-bis(bromomethyl)benzene (1 mol) was dissolved in 1,1,2,2-tetrachloroethane in an open-ended flask with continuous stirring at 120°C for 12 hours. The reaction process was monitored by thin layer chromatography (TLC). When the reaction was complete, the solvent was removed by evaporation under reduced pressure to give 1,4-bis(maleimido)butane (BMI).

References

[1] Tetrahedron Letters, 2013, vol. 54, # 37, p. 5011 - 5013

1,4-BIS-MALEIMIDOBUTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-BIS-MALEIMIDOBUTANE Suppliers

Americas 1 Canada 1 China 57 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 4 United States 17 Global 88
VladaChem GmbH
Tel
+49-7246-3082843
Email
info@vladachem.de
Country
Germany
ProdList
1859
Advantage
58
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
968
Advantage
65

28537-70-4, 1,4-BIS-MALEIMIDOBUTANERelated Search:

2-AMINOETHANETHIOL 1 4-DIMALEIMIDO-2 3-BUTANEDIOL 1,4-BIS-MALEIMIDOBUTANE 1,2-Bis(maleimido)ethane DITHIO-BIS-MALEIMIDOETHANE

  • N,N'-(1,4-Butanediyl)di(maleimide)
  • N,N'-Tetramethylenebis(maleimide)
  • 1-(4-maleimidobutyl)-3-pyrroline-2,5-quinone
  • 1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione
  • TetraMethylenebisMaleiMide
  • TetraMethylenediMaleiMide
  • 1H-Pyrrole-2,5-dione, 1,1'-(1,4-butanediyl)bis-
  • 1,4-Bis-MaleiMidobutane(BMB)
  • 1,1'-(butane-1,4-diyl) bis(1H-pyrrole-2,5-dione)
  • Bis-MaleiMidobutane
  • N,N'-1,4-Butylenebismaleimide
  • 1,4-BIS(MALEIMIDE)BUTANE
  • 1,4-BIS-MALEIMIDOBUTANE
  • 1,4-DI(MALEIMIDO)BUTANE
  • BMB
  • N,N'-(TETRAMETHYLENE)DIMALEIMIDE
  • NSC44747
  • 1,4-Bis(maleimido)butane, BMB, N,Nμ-(Tetramethylene)dimaleimide
  • 1,1'-(1,4-Butanediyl)bis(1H-pyrrole-2,5-dione)
  • 1,1'-(1,4-Butanediyl)bis(3-pyrroline-2,5-dione)
  • 1,4-Bis-maleimidobutane≥ 99% (NMR)
  • BMB (1,4-bismaleimidobutane)
  • 1,4-Bis(maleimido)butane &gt
  • 1,1'-(Butane-1,4-diyl)bis(1H-pyrrole-2,5-dione)
  • BMB Crosslinker
  • 28537-70-4
  • Homobifunctional Crosslinker
  • pharmacetical
  • Maleimide Derivatives
  • Cross Linking Reagents
  • MTS & Sulfhydryl Active Reagents