Isothiazolinones

Description Applications Safety Information

Product Name: Isothiazolinones
CAS No.: 26172-55-4
Chemical Name: Isothiazolinones
Synonyms: CMIT;Isothiazolinone;CMI;CMIT/MIT;5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE;MCI;5-Chloro-2-methyl-3(2H)-isothiazolone;Chloromethylisothiazolinone;5-chloro-2-methyl-2H-isothiazol-3-one;isothiazolin
CBNumber: CB4132565
Molecular Formula: C4H4ClNOS
Formula Weight: 149.6
MOL File: 26172-55-4.mol

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Isothiazolinones Property

Melting point:: 42-45?C
Boiling point:: 109.7°C
Density: 1.25 (14% aq.)
refractive index: n20/D 1.378
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka: -4.06±0.40(Predicted)
form: Liquid
color: White
Odor: Pungent aromatic odor
Stability:: Stable. Incompatible with strong oxidizing agents.
InChI: InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3
InChIKey: DHNRXBZYEKSXIM-UHFFFAOYSA-N
SMILES: S1C(Cl)=CC(=O)N1C
LogP: 0.240 (est)
CAS DataBase Reference: 26172-55-4(CAS DataBase Reference)
NIST Chemistry Reference: 5-Chloro-2-methyl-3(2h)-isothiazolone(26172-55-4)
EPA Substance Registry System: 5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)

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Safety

Hazard Codes: C,N,T,Xn
Risk Statements: 34-43-50-20/21/22-50/53-23/24/25-42/43
Safety Statements: 26-36/37/39-45-60-61-24-28-36/37-23
RIDADR: UN 1760 8/PG 2
WGK Germany: 1
RTECS: NX8156850
HazardClass: 8
PackingGroup: III
HS Code: 3808929090
Hazardous Substances Data: 26172-55-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1597
Product name: CMIT/MIT
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1ml
Price: $97.5
Updated: 2024/03/01

TRC

Product number: C369235
Product name: 5-Chloro-2-methyl-3-isothiazolone
Packaging: 2.5mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: C5029-26
Product name: 5-Chloro-2-
Packaging: 2.5mg
Price: $496
Updated: 2021/12/16

Usbiological

Product number: 435989
Product name: 5-Chloro-2-
Packaging: 1mg
Price: $360
Updated: 2021/12/16

Usbiological

Product number: 161851
Product name: 5-Chloro-2-
Packaging: 1g
Price: $418
Updated: 2021/12/16

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Isothiazolinones Chemical Properties,Usage,Production

Description

Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.

Applications

Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.

Safety Information

The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone.

Description

Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.

Chemical Properties

Liquid

Uses

Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.

Uses

Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.

Uses

Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.

Uses

A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.

Definition

ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.

Toxics Screening Level

Due to a lack of toxicity information on this particular chemical, the screening level is being established under R232(i) at 0.1 μg/m3 with annual averaging.

Isothiazolinones Preparation Products And Raw materials

Raw materials

Chlorine Methyl acrylate

Preparation Products

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Isothiazolinones Suppliers

Belgium 1 Canada 3 China 378 Europe 1 France 1 Germany 3 Greece 1 India 9 Japan 2 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 Thailand 1 United Kingdom 5 United States 26 Global 436

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View Lastest Price from Isothiazolinones manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Isothiazolinone 26172-55-4
Price: US $99.00-35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-14

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Isothiazolinones 26172-55-4
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-06-03

Hebei Mojin Biotechnology Co.,Ltd

Product: Isothiazolinones 26172-55-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-05-23

26172-55-4, IsothiazolinonesRelated Search:

Methanol Paraquat dichloride Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Methylparaben Kresoxim-methyl Acetonitrile 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Basic Violet 1 Methyl acetate Methyl acrylate Isovanillin 1-ADAMANTYL ISOCYANATE 2-Isocyanatoethyl Acrylate ISOCYANIC ACID m-Tolyl isocyanate TERT-BUTYL ISOCYANIDE Isoquinoline-5-sulphonyl chloride hydrochloride Methyl

4-Isothiazolin-3-one,5-chloro-2-methyl-

5-chloro-2-methyl-3(2h)-isothiazolon

5-chloro-2-methyl-4-isothiazolin-3-on

Isothiazolinone

5-Chloro-2-methyl-4-isothiazolinone

5-CHLORIDE-2-METHYL-4-ISOTHIAZOLINE-3-KETONE

5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (CMI)

5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXED WITH 2-METHYL-3(2H)ISOTHIAZOLONE

Methychloroisothiazolinone/Methylisothiazolinone

5-Chloro-2-Methyl-3(2H)-IsothiazoneMixedWith2-Methyl-3(2H)-Isothiazolone

5-Chloro-2-Methyl-3(2H)-Isothiazone

5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (CMIT)

Chloromethylisothiazolinone

Chloromethylisothiazolone

CMI

CMIT

Danisol-K

MCI

Methylchloroisothiazolone

5-Chloro-2-methyl-Isothiazolin-3-one/ 2-Methyl-Isothiazolin-3-one(CMIT/MIT)

5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLE

METHYLCHLOROISOTHIAZOLINONE/METHYLISOTHIAZOLINONE

5-CHLORO-2-METHYL-ISOTHIAZOLIN-3(2H)-ONE

5-CHLORO-2-METHYLISOTHIAZOLINONE

5-CHLORO-2-METHYL-2,3-DIHYDROISOTHIAZOL-3-ONE

METHYL/CHLOROMETHYLISOTHIAZOLINONE

2-METHYL-5-CHLOROISOTHIAZOLIN-3-ONE

5-CHLORO-2-METHYLISOTHIAZOLIN-3-ONE

KATHON886F

KATHONFP

CHLOROMETHYLISOTHIAZOLINE

METHYL(CHLORO)ISOTHIAZOLINONEMIXTURE

KATHON886MW

KATHONLX

CHLORMETHYLISOTHIAZOLINONE

CMIT (5 chloro 2 Methyl 2H isothiazol-3-one

Isothiazolinones(CMI/MI)

3(2H)-Isothiazolone, 5-chloro-2-methyl-

3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone

CMIT/MIT MIXTURE

Isothiazolinones

CMIT/MIT

2-METHYL-5-CHLORO-4-ISO-THIAZOLINE-3-ONE

5-Chloro-2-Methyl-4-isothiazolin-3-one, >14% in water.

CMIT/MIT-14

5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (ACTIVE INGREDIENT >14%, CMI/MI 2.5 - 4.0)

ANTI-IDAS(N-TERMINAL) antibody produced in rabbit

IDAS

Multicilin

Protein Idas

5-cloro-2-methyl-4-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one

Isothiazolinones Solution,100ppm

5-Chloro-2-methyl-3-isothiazolone - Active Ingredient >14%, CMI/MI 2.5 - 4.0

CMIT/MIT-2.5 CG

Methyl chloroisothiazalinone

Kathon.cmit/mit

5-chloro-2-methyl-isothiazolylthione-3

kathoncg5243