pseurotin
- Product Name
- pseurotin
- CAS No.
- 58523-30-1
- Chemical Name
- pseurotin
- Synonyms
- PB-1;pseurotin;NSC 348694;(5S,8S,9R)-8-benzoyl-2-[(Z,1S,2S)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;(5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)-
- CBNumber
- CB41326785
- Molecular Formula
- C22H25NO8
- Formula Weight
- 431.44
- MOL File
- 58523-30-1.mol
pseurotin Property
- Melting point:
- 126.0-126.9℃
- Boiling point:
- 751.5±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (10 mg/ml)
- pka
- 14.76±0.20(Predicted)
- form
- White to off-white powder.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 14441
- Product name
- Pseurotin A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 14441
- Product name
- Pseurotin A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $326
- Updated
- 2024/03/01
- Product number
- 298441
- Product name
- PB1
- Packaging
- 100ug
- Price
- $559
- Updated
- 2021/12/16
- Product number
- 298440
- Product name
- PB1
- Packaging
- 100ug
- Price
- $559
- Updated
- 2021/12/16
- Product number
- P839635
- Product name
- PseurotinA
- Packaging
- 5mg
- Price
- $900
- Updated
- 2021/12/16
pseurotin Chemical Properties,Usage,Production
Description
Pseurotin A (58523-30-1) is a fungal metabolite with novel structure. Displays potent neuritogenic activity in PC12 cells. Induces multipolar and branching neurites comparable to that produced by β-NGF.1 Displays immunosuppressive activity via inhibition of immunoglobulin E production in vitro.2 Displays antiproliferative effects on four glioma cell lines by regulating tumor metabolic enzymes.3 Inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppression of ROS.4
Uses
Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.
Uses
Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production.
Definition
ChEBI: A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.
storage
+4°C
References
1) Komagata et al. (1996), Novel neuritogenic activities of pseurotin A and penicillic acid; J. Antibiot., 49 958 2) Ishikawa et al. (2009), Pseurotin A and its analogues as inhibitors of immunoglobulin E? production; Bioorg, Med. Chem. Lett., 19 1457 3) Anjum et al. (2018), Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes; Nat. Prod. Res., 32 1353 4) Chen et al. (2019), Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species; Theranostics, 9 1634
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