zerumbone
- Product Name
- zerumbone
- CAS No.
- 471-05-6
- Chemical Name
- zerumbone
- Synonyms
- zerumbone;Zerumbone-RM;ZeruMbone (6CI,7CI);Zingiber zerumbe extract;GIHNTRQPEMKFKO-SKTNYSRSSA-N;Zerumbone, NF-kappaB inhibitor;(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone;(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one;(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one;2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (2E,6E,10E)-
- CBNumber
- CB41346756
- Molecular Formula
- C15H22O
- Formula Weight
- 218.33
- MOL File
- 471-05-6.mol
zerumbone Property
- Melting point:
- 67-69℃
- Boiling point:
- 321.6±42.0 °C(Predicted)
- Density
- 0.887±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- LogP
- 4.168 (est)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 43-50
- Safety Statements
- 36/37-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- Z3902
- Product name
- Zerumbone
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $84.1
- Updated
- 2024/03/01
- Product number
- Z3902
- Product name
- Zerumbone
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 15400
- Product name
- Zerumbone
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 15400
- Product name
- Zerumbone
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 15400
- Product name
- Zerumbone
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $234
- Updated
- 2024/03/01
zerumbone Chemical Properties,Usage,Production
Description
Zerumbone (471-05-6) is a natural sesquiterpene ketone isolated from Zingiber sp. Potentiates TRAIL-induced apoptosis via upregulation of death receptor DR4 and DR5 expression. Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells but has no cytotoxic effect on normal cells. Cell permeable.
Uses
Zerumbone has been used:
- for liquid chromatography with mass spectrometry (LC-MS-MS)
- to investigate its potential application in the prevention
- treatment of esophageal squamous cell carcinomas (ESCC)
Definition
ChEBI: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillati n from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).
Anticancer Research
Zerumbone is isolated from the rhizomes of the wild ginger Zingiber zerumbet. It isfound to suppress the proliferation of breast cancer and colon cancer cells and alsoto prevent initiation and promotion of skin cancer in mice. It also suppresses theNF-κB activation and its sequential suppression of IκBα kinase activity, IκBαphosphorylation, IκBα degradation, p65 phosphorylation, nuclear translocation,and acylation. It downregulates the NF-κB-regulated gene products like FLIP, cyclinD1, TRAF1, COX2, Bfl-1/A1, MMP-9, Bcl-xL, ICAM-1, Bcl-2, c-myc, XIAP,survivin, IAP1, and IAP2, and thus, it potentiates apoptosis (Murakami et al. 2002;Sakinah et al. 2007).
References
1) Leu et al. (2009), A small molecule inhibitor of inducible heat shock protein 70; Mol. Cell, 36 15 2) Abdelwahab et al. (2011), Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells; Leuk. Res., 35 268
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View Lastest Price from zerumbone manufacturers
- Product
- Zerumbone; Zingiber zerumbe extract 471-05-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98% HPLC
- Supply Ability
- 1000kg
- Release date
- 2022-09-19