ChemicalBook > CAS DataBase List > Tetraethylammonium Chloride

Tetraethylammonium Chloride

Product Name
Tetraethylammonium Chloride
CAS No.
56-34-8
Chemical Name
Tetraethylammonium Chloride
Synonyms
teac;Tetraethylammonium;TEA CHLORIDE;ETAMON CHLORIDE;SKL1479;N2,2,2,2Cl;ammonium chL;Ethamon chloride;tetraethyl-ammoniuchloride;Tetraethylammonium choride
CBNumber
CB4136114
Molecular Formula
C8H20ClN
Formula Weight
165.7
MOL File
56-34-8.mol
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Tetraethylammonium Chloride Property

Melting point:
39°C
Boiling point:
273.32°C (rough estimate)
Density 
1.08
refractive index 
1.5480 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
white to light yellow
PH
4.0 to 7.0(50g/L, 25℃)
biological source
synthetic (organic)
Water Solubility 
Soluble in water, ethanol, chloroform, or acetone
λmax
λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Sensitive 
Hygroscopic
Merck 
14,9200
BRN 
3563247
Stability:
Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChIKey
YMBCJWGVCUEGHA-UHFFFAOYSA-M
CAS DataBase Reference
56-34-8(CAS DataBase Reference)
EPA Substance Registry System
Tetraethylammonium chloride (56-34-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
BS6125000
F 
3-10
TSCA 
Yes
HS Code 
29239000
Toxicity
LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
113042
Product name
Tetraethylammonium chloride hydrate
Packaging
25g
Price
$58.8
Updated
2024/03/01
Sigma-Aldrich
Product number
113042
Product name
Tetraethylammonium chloride hydrate
Packaging
100g
Price
$187
Updated
2024/03/01
TCI Chemical
Product number
T0095
Product name
Tetraethylammonium Chloride
Purity
>98.0%(T)
Packaging
25g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
T0095
Product name
Tetraethylammonium Chloride
Purity
>98.0%(T)
Packaging
100g
Price
$107
Updated
2024/03/01
Alfa Aesar
Product number
J62507
Product name
Tetraethylammonium chloride
Packaging
25g
Price
$31.5
Updated
2024/03/01
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Tetraethylammonium Chloride Chemical Properties,Usage,Production

Chemical Properties

Tetraethylammonium Chloride is a white crystalline powder. The solubility is 1000000 mg/L at 25 °C.

Uses

Medicine (nerve-blocking agent).

Uses

Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

Uses

Tetraethylammonium chloride (TEAC) has been used:

  • used for inhibition of peroxynitrite induced relaxation in rat aorta rings
  • as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
  • for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Definition

ChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.

General Description

Visit our Sensor Applications portal to learn more.

Hazard

Tetraethylammonium Chloride is a strong irritant to the skin and eyes and may be harmful to the heart and central nervous system. Oral, intraperitoneal and intramuscular lethal dose studies in mice and rats caused drowsiness, tremors and muscle weakness; intravenous injection of 5 mg/kg in humans caused paralysis, mydriasis and ptosis.

Biological Activity

Non-selective K + channel blocker.

Biochem/physiol Actions

Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

in vitro

tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1].

in vivo

vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2]

storage

Room temperature (desiccate)

Purification Methods

Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]

References

[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6.

Tetraethylammonium Chloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-BUTYLXANTHIC ACID POTASSIUM SALT 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 6-O-Benzylguanine
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Tetraethylammonium Chloride Suppliers

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View Lastest Price from Tetraethylammonium Chloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetraethylammonium Chloride 56-34-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-30
Hebei Mujin Biotechnology Co.,Ltd
Product
Tetraethylammonium Chloride 56-34-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Tetraethylammonium Chloride 56-34-8
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-25

56-34-8, Tetraethylammonium ChlorideRelated Search:

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