Description
ChemicalBook > CAS DataBase List > 6-Chloroguanine

6-Chloroguanine

Description
Product Name
6-Chloroguanine
CAS No.
10310-21-1
Chemical Name
6-Chloroguanine
Synonyms
2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;6-CHLORO-2-AMINOPURINE;2-amino-6-chloro-purin;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-Amino-6-chloropuri
CBNumber
CB4143631
Molecular Formula
C5H4ClN5
Formula Weight
169.57
MOL File
10310-21-1.mol
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6-Chloroguanine Property

Melting point:
>300 °C (lit.)
Boiling point:
279.76°C (rough estimate)
Density 
1.4937 (rough estimate)
refractive index 
1.6110 (estimate)
storage temp. 
2-8°C
solubility 
Solubility in 1mol/L NaOH
form 
Powder
pka
6.65±0.20(Predicted)
color 
White to yellow
Water Solubility 
1.7 g/L (20 ºC)
BRN 
9626
InChI
InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey
RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES
N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference
10310-21-1(CAS DataBase Reference)
EPA Substance Registry System
6-Chloro-2-aminopurine (10310-21-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
UO7502000
F 
10
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2861
Product name
Famciclovir Related Compound F
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
109789
Product name
2-Amino-6-chloropurine
Purity
≥99%
Packaging
1g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
109789
Product name
2-Amino-6-chloropurine
Purity
≥99%
Packaging
5g
Price
$31.2
Updated
2024/03/01
TCI Chemical
Product number
A1407
Product name
2-Amino-6-chloropurine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
A1407
Product name
2-Amino-6-chloropurine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$101
Updated
2024/03/01
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6-Chloroguanine Chemical Properties,Usage,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Uses

2-Amino-6-chloropurine may be used:

  • in the enzymatic synthesis of 2′-deoxyguanosine
  • in the synthesis of 9-alkyl purines
  • in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

6-Chloroguanine Preparation Products And Raw materials

Raw materials

Guanine 2,4,5-Triamino-6-chloropyrimidine

Preparation Products

Famciclovir Ganciclovir 6-Thioguanine Penciclovir 6-O-Benzylguanine 2-Amino-6-iodopurine
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View Lastest Price from 6-Chloroguanine manufacturers

Jinan Finer Chemical Co., Ltd
Product
6-Chloroguanine 10310-21-1
Price
US $0.00/Kg/Drum
Min. Order
100g/Bag
Purity
99%
Supply Ability
100mt/year
Release date
2020-09-16
Hebei Zhuanglai Chemical Trading Co Ltd
Product
6-Chloroguanine 10310-21-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-18
WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-Chloroguanine 10310-21-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 TONS
Release date
2021-06-19

10310-21-1, 6-ChloroguanineRelated Search:

2-Amino-4-chloro-6-methoxypyrimidine 4,6-Dimethoxy-2-methylthiopyrimidine 2-Amino-4,6-dimethylpyrimidine 6-Chloroguanine 6-CHLOROGUANINE RIBOSIDE,6-Chloroguanine nucleoside,(-)-2-Amino-6-chloropurine riboside, 6-Chloroguanine riboside 9-(4-Acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine 8-CHLOROGUANINE,CHLOROGUANINE 2-Aminopurine Purine 6-Chloropurine 6-Methoxypurine 2-ACETAMIDO-6-CHLOROPURINE 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE 2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID 9-(4-ACETOXY-3-ACETOXYMETHYLBUTYL)-2-AMINO-6-CHLOROPURINE-D4 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE

  • Clofarabine Impurity 3
  • AURORA KA-689
  • 2-amino-6-chloro-purin
  • 2-AMINO-6-CHLOROPURINE
  • 6-CHLORO-2-AMINOPURINE
  • 6-CHLORO-9H-PURIN-2-YLAMINE
  • 6-CHLOROGUANINE
  • 6-Chloro-7H-purin-2-ylamine
  • TIMTEC-BB SBB003863
  • 6-Chloro-2-purinamine
  • 6-Chloro-7H-purine-2-amine
  • 2-AMINO-6-CHLOROPURINE (2A6ClP)
  • 2-Amino-6-chloropuri
  • 6-chloro-9H-purin-2-amine(SALTDATA: FREE)
  • 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile
  • 2-AMino-6-chlorpurin
  • FaMciclovir Related CoMpound F
  • 2-AMino-6-chloropurine, 98+%
  • 2 - aMino - 6 - chlorine purine
  • Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine)
  • 1H-Purin-2-amine, 6-chloro- (9CI)
  • 2-Amino-6-chlorpurine
  • Purine, 2-amino-6-chloro-
  • 6-chloro-1h-purin-2-amin
  • 6-chloro-1h-purin-2-amine
  • FAMCICLOVIR INTERMEDIATES
  • 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine
  • 2-Amino-6-chloro-9H-purine
  • 6-CHLOROGUANINE CRYSTALLINE
  • 2-Amino-6-Chloropurine(6-Chloroguanine)
  • 1H-Purin-2-amine, 6-chloro-
  • 2-Amino-6-chloro-9H-purine 99%
  • 9H-PURIN-2-AMINE, 6-CHLORO-
  • 6-CHLOROGUANINE extrapure
  • 6-Chloro-7H-purin-2-amine
  • 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine
  • 2-Amino-6-chloropurine &gt
  • 2-Amino-6-Chloro-Purin,>98%
  • Famciclovir USP RC F
  • 6-Chloroguanine USP/EP/BP
  • Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141)
  • Famciclovir USP Related Compound F
  • 2-Amino-6-c2-Amino-6-chloropurinehloropurine
  • Famciclovir Related Compound F (2-Amino-6-chloropurine)
  • Entecavir Impurity 43
  • 10310-21-1
  • 10310-21-2
  • 233-686-7
  • C5H4CIN5
  • C5H4ClN2
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Purines
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleic acids