2-Methyl-3-nitropyridine

Product Name: 2-Methyl-3-nitropyridine
CAS No.: 18699-87-1
Chemical Name: 2-Methyl-3-nitropyridine
Synonyms: 3-NITROPICOLINE;3-NITRO-2-PICOLINE;2-Methyl-3-nitropyri;2-METHYL-3-NITROPYRIDINE;3-NITRO-2-METHYLPYRIDINE;2-Methxy-3-nitropyridine;Pyridine, 2-Methyl-3-nitro-;2-METHYL-3-NITROPYRIDINE 95%;Pyridine, 2-methyl-3-nitro- (9CI);2-Methyl-3-nitropyridine ISO 9001：2015 REACH
CBNumber: CB4150688
Molecular Formula: C6H6N2O2
Formula Weight: 138.12
MOL File: 18699-87-1.mol

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2-Methyl-3-nitropyridine Property

Melting point:: 32-33°
Boiling point:: 86°C/5mmHg(lit.)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to lump
pka: 1.92±0.10(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C6H6N2O2/c1-5-6(8(9)10)3-2-4-7-5/h2-4H,1H3
InChIKey: CCFGTKQIRWHYTB-UHFFFAOYSA-N
SMILES: C1(C)=NC=CC=C1[N+]([O-])=O
CAS DataBase Reference: 18699-87-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2548
Product name: 2-Methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: M2548
Product name: 2-Methyl-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $93
Updated: 2024/03/01

TRC

Product number: M320425
Product name: 2-Methyl-3-nitropyridine
Packaging: 1g
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: U870
Product name: 2-Methyl-3-nitropyridine
Packaging: 1g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 046603
Product name: 2-Methyl-3-nitropyridine
Purity: 95+%
Packaging: 5g
Price: $24
Updated: 2021/12/16

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2-Methyl-3-nitropyridine Chemical Properties,Usage,Production

Uses

2-Methyl-3-nitropyridine is used as a starting reagent to synthesize 3-substituted-4 or 6-azaindoles, and is also used as a reagent to prepare 3-azaindolyl-4-arylmalemides (compounds that exhibit antiproliferative activity).

Reactions

2-Methyl-3-nitropyridine could be used to synthesize dichloro-(3-nitro-2-pyridyl)methylphosphonic dichloride. The chlorination of 2-methyl-3-nitropyridine using a mixture of PCl5 in POCl3[1].

Synthesis Reference(s)

Tetrahedron, 54, p. 6311, 1998 DOI: 10.1016/S0040-4020(98)00328-7
Journal of Heterocyclic Chemistry, 29, p. 359, 1992 DOI: 10.1002/jhet.5570290213
Synthetic Communications, 20, p. 2965, 1990 DOI: 10.1080/00397919008051513

Synthesis

Suzuki Reaction. A mixture of 2-chloro-3-nitro-pyridine 1 (793 mg, 5 mmol), methylboronic acid (329 mg, 5.5 mmol), Pd(PPh3) 4 (578 mg, 0.5 mmol) and K2CO 3 (2.073 g, 15 retool) in dioxane (25 mL) was refluxed for 2 days, then cooled to room temperature and filtered. The solvent was removed and the residue was isolated by chromatography (hexanes-EtOAc = 1:1) to provide 623 mg (90%) of 2-methyl-3-nitropyridine[2].

References

[1] Amrane D, et al. "Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride." Molbank (2022).
[2] Niu, Chuansheng , et al. "Synthesis of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)." 54.23(1998):6311-6318.

2-Methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-3-nitropyridine Suppliers

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View Lastest Price from 2-Methyl-3-nitropyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Methyl-3-nitropyridine 18699-87-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Dideu Industries Group Limited

Product: 2-Methyl-3-nitropyridine 18699-87-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Career Henan Chemical Co

Product: 2-Methyl-3-nitropyridine 18699-87-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-03

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