ChemicalBook > CAS DataBase List > 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Product Name
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
CAS No.
162012-67-1
Chemical Name
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
Synonyms
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;N-(4-(3-chloro-4-fluorophenyl))-7-fluoro-6nitroquinazolin-4-amine;)-7-fL;Afatinib Impurity 76;Afatinib/Dacomitinib;uoro-6-nitroquninazoL;Afatinib intermediate A;4-(3-chloro-4-fiuoro-phen...
CBNumber
CB41512555
Molecular Formula
C14H7ClF2N4O2
Formula Weight
336.68
MOL File
162012-67-1.mol
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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Property

Melting point:
242-244℃
Boiling point:
489℃
Density 
1.616
Flash point:
249℃
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
5.07±0.70(Predicted)
color 
Yellow to Dark Yellow
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Safety

HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3276
Product name
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
Packaging
5G
Price
$163
Updated
2024/03/01
TCI Chemical
Product number
C3276
Product name
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
Packaging
25G
Price
$486
Updated
2024/03/01
TRC
Product number
C376250
Product name
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
Packaging
10g
Price
$970
Updated
2021/12/16
TRC
Product number
C376250
Product name
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
Packaging
100mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
B693
Product name
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline
Packaging
5g
Price
$98
Updated
2021/12/16
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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Chemical Properties,Usage,Production

Uses

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Suppliers

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View Lastest Price from 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- manufacturers

Nanjing Fred Technology Co., Ltd
Product
N-(4-(3-chloro-4-fluorophenyl))-7-fluoro-6nitroquinazolin-4-amine 162012-67-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Hebei Yanxi Chemical Co., Ltd.
Product
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 162012-67-1
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-06
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Afatinib impurity 76
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-04

162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-Related Search:

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Aprepitant methyl(E)-4-(methylamino)but-2-enoate (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine TRANS-4-AMINOCROTONIC ACID 7-Fluoro-4-quinazolone Afatinib impurity 45 Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine trans-4-Dimethylaminocrotonic acid hydrochloride (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Afatinib Afatinib dimaleate (S)-(+)-3-Hydroxytetrahydrofuran Afatinib (BIBW 2992) 7-Fluoro-6-nitro-4-hydroxyquinazoline 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
  • N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
  • 4-(3-chloro-4-fiuoro-phen...
  • 4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline
  • N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide
  • (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • Afatinib intermediate A
  • 3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)
  • N-(3-chloro-4-fluorophenyl)-7-fiuoro-6-nitro-4-quinazolinaMine
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
  • Afatinib int-1 N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • N-(3-Cl-4-F-phenyl)-7-F-6-NO2-4-quinazolinamine
  • 4-Quizolimine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
  • 4-[(3-Chloro-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline
  • Afatinib Impurity 76
  • N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro quinazoline-4-amine
  • N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquninazoline
  • uoro-6-nitroquninazoL
  • N-(4-(3-chloro-4-fluorophenyl))-7-fluoro-6nitroquinazolin-4-amine
  • )-7-fL
  • 4- quinazoline amine, N- (3-chloro-4-fluorophenyl) -7-fluoro-6-nitro -
  • 4-(3-Chloro-4-fluoroanilino)-7-fluoro-6-nitroquinazoline
  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ISO 9001：2015 REACH
  • N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-ni...
  • Afatinib/Dacomitinib
  • N - (3-chloro-4-fluorophenyl) -7-fluoro-6-nitro-4-quinazoline amine
  • 162012-67-1
  • C14H7ClF2N4O2
  • API intermediates
  • 162012-67-1