ChemicalBook > CAS DataBase List > 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Product Name: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
CAS No.: 162012-67-1
Chemical Name: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
Synonyms: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;N-(4-(3-chloro-4-fluorophenyl))-7-fluoro-6nitroquinazolin-4-amine;)-7-fL;Afatinib Impurity 76;Afatinib/Dacomitinib;uoro-6-nitroquninazoL;Afatinib Impurity 114;Afatinib intermediate A
CBNumber: CB41512555
Molecular Formula: C14H7ClF2N4O2
Formula Weight: 336.68
MOL File: 162012-67-1.mol

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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Property

Melting point:: 242-244℃
Boiling point:: 489℃
Density: 1.616
Flash point:: 249℃
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 5.07±0.70(Predicted)
color: Yellow to Dark Yellow

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Safety

HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3276
Product name: N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
Packaging: 5G
Price: $147
Updated: 2025/07/31

TCI Chemical

Product number: C3276
Product name: N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
Packaging: 25G
Price: $437
Updated: 2025/07/31

TRC

Product number: C376250
Product name: 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
Packaging: 10g
Price: $970
Updated: 2021/12/16

TRC

Product number: C376250
Product name: 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
Packaging: 100mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: B693
Product name: 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline
Packaging: 5g
Price: $98
Updated: 2021/12/16

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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Chemical Properties,Usage,Production

Uses

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Synthesis

162012-69-3

367-21-5

162012-67-1

The general procedure for the synthesis of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine from 7-fluoro-6-nitro-4-hydroxyquinazoline and 3-chloro-4-fluoroaniline is as follows: Method 1 (one-pot reaction): 1. 7-fluoro-6-nitro-4-hydroxyquinazoline (5 g, 23.9 mmol) was added to a 100 mL single neck flask. 2. Phosphoryl chloride (44.6 mL, 478 mmol) was added and heated to reflux at 150 °C for 5 hours. 3. Upon completion of the reaction, phosphorous trichloride was removed by evaporation. 4. The residue was diluted with anhydrous dichloromethane and evaporated again, and the process was repeated 3 times. 5. After dilution with acetonitrile (100 mL), 3-chloro-4-fluoroaniline (2.3 g, 15.8 mmol) was added. 6. 6. Heat to reflux overnight and a yellow solid precipitated during the reaction. 7. The yellow solid was filtered and dried to afford the target product N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine (4.8 g, 56% yield). Product characterization data: 1H-NMR (d-DMSO, 400 MHz, δppm): 10.61 (br, 1H), 9.68 (d, J=10.8 Hz, 1H), 8.81 (s, 1H), 8.10-8.13 (d, J=7.6 Hz, 1H), 8.05-8.07 (d, J=8 Hz, 1H), 7.81-7.85 (m. 1H), 7.50-7.54 (d, J=8Hz, 1H).

References

[1] Patent: EP3181553, 2017, A1. Location in patent: Paragraph 0123; 0124

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- manufacturers

Moxin Chemicals

Product: Afatinib Impurity 162012-67-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-06-04

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- 162012-67-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 162012-67-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-06

162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-Related Search:

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Aprepitant methyl(E)-4-(methylamino)but-2-enoate (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine TRANS-4-AMINOCROTONIC ACID 7-Fluoro-4-quinazolone Afatinib impurity 45 Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine trans-4-Dimethylaminocrotonic acid hydrochloride (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Afatinib Afatinib dimaleate (S)-(+)-3-Hydroxytetrahydrofuran Afatinib (BIBW 2992) 7-Fluoro-6-nitro-4-hydroxyquinazoline 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

4-(3-chloro-4-fiuoro-phen...

4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline

N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide

(3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine

N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine

Afatinib intermediate A

3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)

N-(3-chloro-4-fluorophenyl)-7-fiuoro-6-nitro-4-quinazolinaMine

N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine

Afatinib int-1 N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine

N-(3-Cl-4-F-phenyl)-7-F-6-NO2-4-quinazolinamine

4-Quizolimine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-[(3-Chloro-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

Afatinib Impurity 76

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro quinazoline-4-amine

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquninazoline

uoro-6-nitroquninazoL

N-(4-(3-chloro-4-fluorophenyl))-7-fluoro-6nitroquinazolin-4-amine

)-7-fL

4- quinazoline amine, N- (3-chloro-4-fluorophenyl) -7-fluoro-6-nitro -

4-(3-Chloro-4-fluoroanilino)-7-fluoro-6-nitroquinazoline

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ISO 9001：2015 REACH

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-ni...

Afatinib/Dacomitinib

N - (3-chloro-4-fluorophenyl) -7-fluoro-6-nitro-4-quinazoline amine

162012-67-1N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine

N - (3-chloro-4-fluorophenyl) -7-fluoro-6-nitro-4-quinolone amine

Afatinib Impurity 114

162012-67-1

C14H7ClF2N4O2

API intermediates

162012-67-1