ChemicalBook > CAS DataBase List > MAHMA NONOATE

MAHMA NONOATE

Product Name
MAHMA NONOATE
CAS No.
146724-86-9
Chemical Name
MAHMA NONOATE
Synonyms
NOC-9;MAHMA/NO;MAHMA NONOATE;noc-9crystalline;MAHMA NONOate,97%;METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE;methyl-[6-[methyl-[nitroso(oxido)amino]amino]hexyl]azanium;1-HYDROXY-2-OXO-3-(N-METHYL-6-AMINOHEXYL)-3 METHYL-1-TRIAZENE;6-(2-HYDROXY-1-METHYL-2-NITROSOHYDRAZINO)-N-METHYL-1-HEXANAMINE;1-Hexanamine, 6-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-
CBNumber
CB4152738
Molecular Formula
C8H20N4O2
Formula Weight
204.27
MOL File
146724-86-9.mol
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MAHMA NONOATE Property

Melting point:
102-108 °C
Boiling point:
301.7±44.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
−70°C
solubility 
Soluble in water highly
form 
White to off-white crystalline solid.
pka
0.45±0.69(Predicted)
color 
Off-white to light yellow
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29270000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1555
Product name
MAHMA NONOate
Packaging
50mg
Price
$148
Updated
2025/07/31
Cayman Chemical
Product number
82130
Product name
MAHMA NONOate
Purity
≥98%
Packaging
10mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
82130
Product name
MAHMA NONOate
Purity
≥98%
Packaging
25mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
82130
Product name
MAHMA NONOate
Purity
≥98%
Packaging
50mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
82130
Product name
MAHMA NONOate
Purity
≥98%
Packaging
100mg
Price
$179
Updated
2024/03/01
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MAHMA NONOATE Chemical Properties,Usage,Production

Description

MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.

Chemical Properties

white to off-white crystalline solid

Uses

MAHMA NONOate is a diazeniumdiolate quick-releasing NO donor.

in vivo

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2].

Animal Model:Male Wistar rats anaesthetised with pentobarbitone[2]
Dosage:0.3-10 nmol/kg/min
Administration:Intravenous injection; 0.3-10 nmol/kg/min once
Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.

References

[1] L K KEEFER. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.[J]. Methods in enzymology, 1996, 268: 281-293. DOI: 10.1016/s0076-6879(96)68030-6
[2] TENG LI. Rational Design and Bioimaging Applications of Highly Specific “Turn-On” Fluorescent Probe for Hypochlorite[J]. Bioconjugate Chemistry Bioconjugate, 2018, 29 8: 2838-2845. DOI: 10.1021/acs.bioconjchem.8b00430

MAHMA NONOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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MAHMA NONOATE Suppliers

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146724-86-9, MAHMA NONOATERelated Search:

Sodium nitroprusside dihydrate NOC-18 DPTA NONOATE SPERMINE NONOATE NOC-7 4-(N-CYANOMETHYL-N-NITROSO)AMINOMORPHOLINE S-NITROSOGLUTATHIONE NOC-5 DEA NONOate GEA 5024 NOC-12 V-PYRRO/NO PAPA NONOATE GEA 3162 BETA-GAL-NONOATE NOR-3 MAHMA NONOATE

  • MAHMA/NO
  • MAHMA NONOATE
  • METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE
  • (Z)-1-[N-METHYL-N-[6-(N-METHYLAMMONIOHEXYL)AMINO]]DIAZEN-1-IUM-1,2-DIOLATE
  • noc-9crystalline
  • 1-HYDROXY-2-OXO-3-(N-METHYL-6-AMINOHEXYL)-3 METHYL-1-TRIAZENE
  • 6-(2-HYDROXY-1-METHYL-2-NITROSOHYDRAZINO)-N-METHYL-1-HEXANAMINE
  • NOC-9
  • NOC-9, 6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine
  • MAHMA NONOate,97%
  • MAHMA NONOATE;1-HYDROXY-2-OXO-3(N-METHYL-6-AMINOHEXYL)-3-METHYL-1-TRIAZENE;NOC-9
  • methyl-[6-[methyl-[nitroso(oxido)amino]amino]hexyl]azanium
  • 1-Hexanamine, 6-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)-N-methyl-
  • 146724-86-9
  • C8H20N4O2
  • NO Donors
  • Nitric Oxide Metabolism
  • Enzymes, Inhibitors, and Substrates
  • Biochemicals and Reagents
  • Application Index
  • BioChemical
  • Cell Signaling Enzymes