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FLUPHENAZINE HYDROCHLORIDE

Product Name
FLUPHENAZINE HYDROCHLORIDE
CAS No.
146-56-5
Chemical Name
FLUPHENAZINE HYDROCHLORIDE
Synonyms
FLUPHENAZINE HCL;FLUPHENAZINE DIHYDROCHLORIDE;Prolinate;prolixin;anatensol;omca;a4077;liogen;moditen;mirenil
CBNumber
CB4154808
Molecular Formula
C22H28Cl2F3N3OS
Formula Weight
510.44
MOL File
146-56-5.mol
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FLUPHENAZINE HYDROCHLORIDE Property

Melting point:
200-2020C
storage temp. 
2-8°C
solubility 
Soluble in DMSO and methanol.
form 
Solid
color 
White to Light yellow
Sensitive 
Hygroscopic
Stability:
Hygroscopic
EPA Substance Registry System
Fluphenazine dihydrochloride (146-56-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36/37/39-36
RIDADR 
UN2811
WGK Germany 
3
RTECS 
TL9800000
HazardClass 
6.1
PackingGroup 
III
HS Code 
2934302300
Toxicity
guinea pig,LD50,intraperitoneal,299mg/kg (299mg/kg),Pharmazie. Vol. 38, Pg. 749, 1983.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F-903
Product name
Fluphenazine dihydrochloride solution
Purity
1.0?mg/mLinmethanol(asfreebase),ampuleof1?mL,certifiedreferencemateri
Packaging
1mL
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
BP167
Product name
Fluphenazine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
1282004
Product name
Fluphenazine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
F4765
Product name
Fluphenazine dihydrochloride
Packaging
1g
Price
$85.9
Updated
2023/06/20
TCI Chemical
Product number
F1240
Product name
Fluphenazine Dihydrochloride
Packaging
1G
Price
$42
Updated
2024/03/01
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FLUPHENAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Prolixin, Squibb ,US ,1959

Uses

antiandrogen, antineoplastic, Nuclear Hormone receptor antagonist

Uses

Antipsychotic

Definition

ChEBI: Fluphenazine hydrochloride is a member of phenothiazines. It has a role as an anticoronaviral agent.

Manufacturing Process

A suspension of 69.0 grams of 2-trifluoromethylphenothiazine in 1 liter of toluene with 10.9 grams of sodium amide is heated at reflux with high speed stirring for 15 minutes. A solution of 54.1 grams of 1-formyl-4-(3'chloropropyl)-piperazine, [prepared by formylating 1-(3'-hydroxypropyl)piperazine by refluxing in an excess of methyl formate, purifying the 1-formyl4-(3'-hydroxypropyl)-piperazine by vacuum distillation, reacting this compound with an excess of thionyl chloride at reflux and isolating the desired 1-formyl-4(3'-chloropropyl)-piperazine by neutralization with sodium carbonate solution followed by distillation] in 200 ml of toluene is added. The reflux period is continued for 4 hours. The cooled reaction mixture is treated with 200 ml of water. The organic layer is extracted twice with dilute hydrochloric acid. The acid extracts are made basic with ammonia and extracted with benzene. The volatiles are taken off in vacuo at the steam bath to leave a dark brown oil which is 10-[3'-(N-formylpiperazinyl)-propyl]-2trifluoromethylphenothiazine. It can be distilled at 260°C at 10 microns, or used directly without distillation if desired.
A solution of 103.5 grams of 10-[3'-(N-formylpiperazinyl)-propyl]-2trifluoromethylphenothiazine in 400 ml of ethanol and 218 ml of water containing 26 ml of 40% sodium hydroxide solution is heated at reflux for 2 hours. The alcohol is taken off in vacuo on the steam bath. The residue is swirled with benzene and water. The dried benzene layer is evaporated in vacuo. The residue is vacuum distilled to give a viscous, yellow oil, 10(3'piperazinylpropyl)-2-trifluoromethylphenothiazine, distilling at 210° to235°C at 0.5 to 0.6 mm.
A suspension of 14.0 grams of 10-(3'-piperazinylpropyl)-2trifluoromethylphenothiazine, 6.4 grams of β-bromoethyl acetate and 2.6 grams of potassium carbonate in 100 ml of toluene is stirred at reflux for 16 hours. Water (50 ml) is added to the cooled mixture. The organic layer is extracted into dilute hydrochloric acid. After neutralizing the extracts and taking the separated base up in benzene, a viscous, yellow residue is obtained by evaporating the organic solvent in vacuo. This oil is chromatographed on alumina. The purified fraction of 7.7 grams of 10-[3'-(Nacetoxyethylpiperazinyl)-propyl] -2-trifluoromethylphenothiazine is taken up in ethyl acetate and mixed with 25 ml of alcoholic hydrogen chloride. Concentration in vacuo separates white crystals of the dihydrochloride salt, MP 225° to 227°C.
A solution of 1.0 gram of 10-[3'-(N-acetoxyethylpiperazinyl)-propyl]-2trifluoromethylphenothiazine in 25 ml of 1 N hydrochloric acid is heated at reflux briefly. Neutralization with dilute sodium carbonate solution and extraction with benzene gives the oily base, 10-[3'-(N-βhydroxyethylpiperazinyl)-propyl]-2-trifluoromethylphenothiazine. The base is reacted with an excess of an alcoholic hydrogen chloride solution. Trituration with ether separates crystals of the dihydrochloride salt, MP 224° to 226°C, (from US Patent 3,058,979).

Therapeutic Function

Tranquilizer

General Description

The member ofthe piperazine subgroup with a trifluoromethyl group at the2-position of the phenothiazine system and the most potentantipsychotic phenothiazine on a milligram basis is fluphenazinehydrochloride, 4-[3-[2-(trifluoromethyl)phenazin-10-yl] propyl]-1-piperazineethanol dihydrochloride, 10[3-[4-(2-hydroxyethyl)piperazinyl]propyl]-2-trifluoromethylphenothiazine dihydrochloride (Permitil, Prolixin). It is alsoavailable as two lipid-soluble esters for depot intramuscularinjection, the enanthate (heptanoic acid ester) and the decanoateester. These long-acting preparations have use intreating psychotic patients who do not take their medicationor are subject to frequent relapse.

Biological Activity

ec50: 1.24 μmfluphenazine is a dopamine d1 and d2 receptor inhibitor.dopamine d1 and d2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons.

Biochem/physiol Actions

D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.

in vitro

previous study showed that both phenothiazines of fluphenazine and perphenazine induced concentration-dependent loss in cell viability with ec50s to be 1.24 and 2.76 μm for fluphenazine and perphenazine, respectively. moreover, fluphenazine at 1.0 μm and perphenazine at 1.0 and 3.0 μm could inhibit melanogenesis and decrease the content of microphthalmia-associated transcription factor. in addition, both fluphenazine and perphenazine at higher concentrations caused depletion of melanocytes antioxidant status, indicating oxidative stress induction [1].

in vivo

systemic fluphenazine could effectively attenuate mechanical allodynia in rat neuropathic pain models at 0.03-0.3 mg/kg doses, which approximated those used in rodent models of psychosis. for antiallodynic effect, fluphenazine was able to effectively suppress the ectopic discharges in injured afferent fibers without affecting the propagation of action potentials in an ex-vivo drg-nerve preparation from cci rats [2].

References

[1] otreba m et al. fluphenazine and perphenazine impact on melanogenesis and antioxidant enzymes activity in normal human melanocytes. acta poloniae pharmaceutica-drug research, july-august 2016, 73(4):903-911.
[2] dong xw,jia y,lu sx,zhou x,cohen-williams m,hodgson r,li h,priestley t. the antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain. psychopharmacology (berl). 2008 jan;195(4):559-68.

FLUPHENAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FLUPHENAZINE HYDROCHLORIDE Suppliers

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View Lastest Price from FLUPHENAZINE HYDROCHLORIDE manufacturers

Henan Bao Enluo International TradeCo.，LTD
Product
Fluphenazine DiHCl 146-56-5
Price
US $150.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-06-06
Dideu Industries Group Limited
Product
FLUPHENAZINE HYDROCHLORIDE 146-56-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23
Career Henan Chemical Co
Product
FLUPHENAZINE HYDROCHLORIDE 146-56-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg , 5kg, 50kg
Release date
2020-01-17

146-56-5, FLUPHENAZINE HYDROCHLORIDERelated Search:

Promazine hydrochloride Promazine PIPERAZINE DIHYDROCHLORIDE 1,3-DIAMINOPROPANE DIHYDROCHLORIDE 1-(3-AMINOPROPYL)-4-METHYLPIPERAZINE 1-(2-Hydroxyethyl)-4-methylpiperazine Phenothiazine 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 1-(3-AMINOPROPYL)PIPERAZINE 1,3-Propanediamine,N3,N3-diethyl-1-phenyl- 10-METHYLPHENOTHIAZINE 4-TRIFLUOROMETHYL DIPHENYL SULFIDE TRIFLUPROMAZINE HYDROCHLORIDE 2-(Trifluoromethyl)phenothiazine 3-AMINO-4-MERCAPTOBENZOTRIFLUORIDE HYDROCHLORIDE 1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE triflupromazine Trifluoperazine dihydrochloride Fluphenazine Dihydrochloride

  • 10-(3-(4-(2-hydroxyethyl)piperazinyl)propyl)-2-trifluoromethylphenothiazine
  • 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazineethanodihy
  • 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazineethanol,dihy
  • 4-[3[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-1-piperazineethano
  • a4077
  • anatensol
  • flufenazin
  • liogen
  • lyorodin
  • mirenil
  • moditen
  • omca
  • permitilhydrochloride
  • prolixin
  • squibb4918
  • tensofin
  • 2-(4-(3-(2-(trifluoroMethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol dihydrochloride
  • Prolinate
  • Siqualone
  • 1-Piperazineethanol,4-[3-[2-(trifluoroMethyl)-10H-phenothiazin-10-yl]propyl]-, hydrochloride (1:2)
  • Fluphenazine DiHCl
  • 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol,dihydrochloride
  • 2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol dihydrochloride
  • 4-[3-[2-(TRIFLUOROMETHYL)-10H-PHENO-THIAZIN-10-YL]-1-PIPERAZINEETHANOL 2HCL
  • 4-[3-[2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZIN-10-YL]PROPYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE
  • FLUPHENAZINE HCL
  • FLUPHENAZINE HYDROCHLORIDE
  • FLUPHENAZINE DIHYDROCHLORIDE
  • 4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1- piperazineethanol Dihydrochloride
  • Tensofi
  • 1-Piperazineethanol, 4-3-2-(trifluoromethyl)-10H-phenothiazin-10-ylpropyl-, dihydrochloride
  • FLUPHENAZINE HYDROCHLORIDE USP
  • trancin
  • Fluphenazine Hydrochloride (125 mg)
  • Fluphenazine·dihydrochloric acid
  • Fluphenazine Hydrochoride
  • Fluphenazine impurity mixture CRS
  • Fluphenazine dihydrochloride CRS
  • Fluphenazine DiHCl (Fluphenazine Decanoate EP Impurity B DiHCl)
  • uphenazine dihydrochL
  • Fluphenazine Enantate EP Impurity B
  • FLUPHENAZINE HYDROCHLORIDE USP/EP/BP
  • Fluphenazine dihydrochloride (F0280000)
  • Fluphenazine Hydrochloride (1282004)
  • Fluphenazine dihydrochloride in methanol
  • Fluphenazine-2HCl in Methanol
  • Fluphenazine hydrochloride, dopamine D2/D1 receptor antagonist
  • 146-56-5
  • C22H27ClF3N3OS
  • C22H28Cl2F3N3OS
  • C22H28F3N3OSCl2
  • C22H26F3N3OS2HCl
  • EULEXIN
  • Heterocyclic Compounds
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds