ChemicalBook > CAS DataBase List > 2,4-Dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol

Product Name
2,4-Dichlorobenzyl alcohol
CAS No.
1777-82-8
Chemical Name
2,4-Dichlorobenzyl alcohol
Synonyms
Myacide;Dybenal;myacidesp;Rapidosept;DYBENAL(R);RARECHEM AL BD 0019;2,4-Dichlorobenzyl a;Oxiconazole USP RC D;LABOTEST-BB LT01985654;Miconazole Impurity 14
CBNumber
CB4156352
Molecular Formula
C7H6Cl2O
Formula Weight
177.03
MOL File
1777-82-8.mol
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2,4-Dichlorobenzyl alcohol Property

Melting point:
55-58 °C(lit.)
Boiling point:
150 °C (25 mmHg)
Density 
1.2970 (rough estimate)
vapor pressure 
0.154Pa at 25℃
refractive index 
1.5756 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
1g/l
pka
13.60±0.10(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water, methanol and chloroform.
Merck 
14,3060
BRN 
1448652
InChIKey
DBHODFSFBXJZNY-UHFFFAOYSA-N
LogP
2.8 at 24℃
CAS DataBase Reference
1777-82-8(CAS DataBase Reference)
EPA Substance Registry System
2,4-Dichlorobenzenemethanol (1777-82-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
2
RTECS 
DO0890000
Hazard Note 
Irritant
HS Code 
29062900
Toxicity
mouse,LD50,oral,2300mg/kg (2300mg/kg),Cosmetics and Toiletries. Vol. 95(6), Pg. 59, 1980.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001620
Product name
2,4-Dichlorobenzyl alcohol
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001620
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
146668
Product name
2,4-Dichlorobenzyl alcohol
Purity
99%
Packaging
50g
Price
$148
Updated
2024/03/01
TCI Chemical
Product number
D1837
Product name
2,4-Dichlorobenzyl Alcohol
Purity
>97.0%(GC)
Packaging
25g
Price
$42
Updated
2024/03/01
Alfa Aesar
Product number
A13338
Product name
2,4-Dichlorobenzyl alcohol, 99%
Packaging
25g
Price
$57.65
Updated
2024/03/01
Alfa Aesar
Product number
A13338
Product name
2,4-Dichlorobenzyl alcohol, 99%
Packaging
100g
Price
$172.65
Updated
2024/03/01
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2,4-Dichlorobenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

An surgical antiseptic.

Uses

2,4-Dichlorobenzyl alcohol is an antiseptic found in commercially available throat lozenges. Also used deactivate Respiratory syncytial virus and SARS-Cov.

Definition

ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.

General Description

2,4-Dichlorobenzyl alcohol is a constituent of commercially available lozenges for acute sore throat caused by upper respiratory tract infections.

Mechanism of action

In-vitro evidence has demonstrated the virucidal effect of Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) on a number of viruses associated with the common cold; a reduction in viral load is believed to have benefits in reducing the symptoms. The local anesthetic action of AMC/DCBA throat lozenges, a combination of the potent channel blocker – AMC and the reduced potency for sodium channel blockade DCBA – attenuate the effects of AMC, possibly as a result of competitive binding, which acts on a sodium channel blocker, and may be effective in relieving symptoms due to inflammation. Therefore, AMC/DCBA throat lozenge is thought to represent a useful option to meet patients' needs and avoid unnecessary prescription of antibiotics[1].

Clinical Use

Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been marketed in many countries worldwide for pain relief in acute sore throat. Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been shown to be safe and efficient in relieving of acute sore throat symptoms, and it produces an immediate symptomatic relief. Local symptomatic pain relief plays an important role in managing acute sore throat[1-2].

Side effects

COMMON SIDE EFFECTS: Difficulty in breathing, Tongue soreness, Hypersensitivity reactions, Swelling of the face, Tongue, Throat and Neck.

References

[1] Ting W Tan. “Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol.” JBI database of systematic reviews and implementation reports (2017): 862–872.
[2] Thomas, Michael J. “ACP Journal Club. Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat.” Annals of Internal Medicine 153 4 (2010): JC2-6.

2,4-Dichlorobenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

Imazalil
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2,4-Dichlorobenzyl alcohol Suppliers

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View Lastest Price from 2,4-Dichlorobenzyl alcohol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2, 4-Dichlorobenzyl Alcohol 1777-82-8
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-03
Hebei Yanxi Chemical Co., Ltd.
Product
2,4-Dichlorobenzyl alcohol 1777-82-8
Price
US $30.00-23.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-14
Hebei Weibang Biotechnology Co., Ltd
Product
2,4-Dichlorobenzyl alcohol 1777-82-8
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

1777-82-8, 2,4-Dichlorobenzyl alcoholRelated Search:

4-Hydroxybenzyl alcohol 4-Methoxybenzyl alcohol 4,4'-Bis(chloromethyl)-1,1'-biphenyl 4-Nitrobenzyl alcohol 1,3-Bis(chloromethyl)benzene Thionyl chloride Dichloroethane Triphenylmethanol 4,6-Dichloropyrimidine Ethyl acetate Dichloroacetic acid Benzyl alcohol 2,3-DICHLOROBENZYL ALCOHOL 99%,2,3-DICHLOROBENZYL ALCOHOL Miconazole Impurity Isoconazole Miconazole IMpurity I alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Miconazole IMpurity H

  • 2,4-dichloro-benzylalcoho
  • benzylalcohol,2,4-dichloro-
  • myacidesp
  • 2,4-DichlorobenzylAlcohol99%
  • Benzenemethanol, 2,4-dichloro-
  • 2,4-DICHLOROBENZL ALCOHOL
  • 30) 2,4-DICHLORO BENZYL ALCOHOL
  • Rapidosept
  • Myacide
  • 2,4-Dichlorobenzyl a
  • 4-Dichlorobenzyl alcohol
  • Miconazole Related Compound (2,4-Dichlorobenzyl Alcohol)
  • (2,4-DICHLOROPHENYL)METHANOL
  • 2,4-Dichloro-benzenemethanol
  • 2,4-DICHLOROBENZYL ALCOHOL
  • 2,4-DICHLOROBENZOYL ALCOHOL
  • LABOTEST-BB LT01985654
  • Dybenal
  • DYBENAL(R)
  • RARECHEM AL BD 0019
  • Miconazole Nitrate Impurity A
  • 2,4-Dichlorobenzyl Alcohol &gt
  • 2,4-Dichlorobenzyl alcohol CRS
  • Oxiconazole USP RC D
  • Miconazole Impurity 14
  • Oxiconazole Related Compound D
  • Oxiconazole USP Related Compound D
  • 2,4-Dichlorbenzylalkohol
  • Oxiconazole Impurity 4 (Oxiconazole USP RC D)
  • 2, 4 – DICHLORO BENZYL ALCOHOL – BP/EP
  • C12410500 2,4-DichlorobenzyLalcohol
  • Miconazole Nitrate Impurity 10
  • 1777-82-8
  • 1777-24-6
  • 1777-83-8
  • C7H6Cl2O
  • C7 to C8
  • Alcohols
  • Building Blocks
  • Organic Building Blocks
  • Oxygen Compounds
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Building Blocks
  • C7 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Benzhydrols, Benzyl & Special Alcohols
  • Alcohols
  • C7 to C8
  • Oxygen Compounds