5-Fluoro-3-methylindole
- Product Name
- 5-Fluoro-3-methylindole
- CAS No.
- 392-13-2
- Chemical Name
- 5-Fluoro-3-methylindole
- Synonyms
- 5-Fluoro-3-methyl-1H-indole;5-FLUORO-3-METHYLINDOLE;1H-5-Fluoro-3-methyindole;1H-5-FLUORO-3-METHYLINDOLE;1H-Indole, 5-fluoro-3-methyl-
- CBNumber
- CB4170831
- Molecular Formula
- C9H8FN
- Formula Weight
- 149.16
- MOL File
- 392-13-2.mol
5-Fluoro-3-methylindole Property
- Melting point:
- 83.0 to 87.0 °C
- Boiling point:
- 269.2±20.0 °C(Predicted)
- Density
- 1.219±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 16.46±0.30(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C9H8FN/c1-6-5-11-9-3-2-7(10)4-8(6)9/h2-5,11H,1H3
- InChIKey
- CSDHAGJNOQIBHZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2)C(C)=C1
- CAS DataBase Reference
- 392-13-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 25
- Safety Statements
- 36/37/39-45
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F1053
- Product name
- 5-Fluoro-3-methylindole
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $63
- Updated
- 2025/07/31
- Product number
- F1053
- Product name
- 5-Fluoro-3-methylindole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- F597990
- Product name
- 5-Fluoro-3-methylindole
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- F597990
- Product name
- 5-Fluoro-3-methylindole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597990
- Product name
- 5-Fluoro-3-methylindole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
5-Fluoro-3-methylindole Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
5-Fluoro-3-methylindole is used to study its ionization potential and the origin of nonexponential tryptophan fluorescnece decay in proteins.
Synthesis
2338-71-8
392-13-2
5-Fluoro-1H-indole-3-carboxaldehyde (3.2 g, 19.6 mmol) was used as raw material and dissolved in 10 mL of anhydrous tetrahydrofuran. Subsequently, lithium aluminum hydride (2.61 g, 68.6 mmol) was added to this solution. The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 18 mL of 20% sodium hydroxide aqueous solution. The mixture was extracted by adding 60 mL of dichloromethane to the mixture and the organic layer was washed with 40 mL of saturated aqueous sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (V/V=50/1) as eluent to afford 5-fluoro-3-methylindole as a light yellow solid (2.41 g, 82.3% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 150.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ: 7.30-7.23 (m, 2H), 7.04 (s, 1H), 6.97 (td, J=9.0,2.0 Hz, 1H), 2.33 (s, 3H).
References
[1] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00362
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3250 - 3254
[3] Angew. Chem., 2013, vol. 125, # 11, p. 3332 - 3336,5
[4] Organic Letters, 2015, vol. 17, # 11, p. 2652 - 2655
5-Fluoro-3-methylindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-3-methylindole manufacturers
- Product
- 5-Fluoro-3-methylindole 392-13-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- 5-Fluoro-3-Methylindole 392-13-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-26
- Product
- 5-Fluoro-3-methyl-1H-indole 392-13-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-15