ChemicalBook > CAS DataBase List > Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate

Product Name
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
CAS No.
571-55-1
Chemical Name
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
Synonyms
ethyl 2-(ethoxyMethylene)-4,4,4-trifluoro-3-oxobutanoate;Ethyl (E)-2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate;ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate;Ethyl 2-(ethoxymethylene)-4,4,4-;ETHYL 3-ETHOXY-2-(2,2,2-TRIFLUOROACETYL)ACRYLATE;ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobu;ETHYL ETHOXYMETHYLENE-3-OXO-4,4,4-TRIFLUOROBUTYRATE;ETHYL 2-(ETHOXYMETHYLENE)-4,4,4-TRIFLUOROACETOACETATE;Ethyl 3-ethoxy-2-(2,2,2-trifluoroacetyl)acrylate, Tech.;ETHYL 2-(ETHOXYMETHYLENE)-4,4,4-TRIFLUORO-3-OXOBUTYRATE
CBNumber
CB4171944
Molecular Formula
C9H11F3O4
Formula Weight
240.18
MOL File
571-55-1.mol
More
Less

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Property

Boiling point:
80-82 °C1 mm Hg(lit.)
Density 
1.235 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.429(lit.)
Flash point:
220 °F
storage temp. 
2-8°C
form 
clear liquid
color 
Light orange to Yellow to Green
Specific Gravity
1.239
InChI
InChI=1S/C9H11F3O4/c1-3-15-5-6(8(14)16-4-2)7(13)9(10,11)12/h5H,3-4H2,1-2H3
InChIKey
XNGGOXOLHQANRB-WAYWQWQTSA-N
SMILES
C(OCC)(=O)C(=COCC)C(=O)C(F)(F)F
CAS DataBase Reference
571-55-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-23
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29171900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
441236
Product name
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate,mixture of cis and trans
Purity
96%
Packaging
10g
Price
$39.35
Updated
2025/07/31
TCI Chemical
Product number
E1087
Product name
Ethyl 2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate
Purity
>96.0%(GC)
Packaging
5g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
E1087
Product name
Ethyl 2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate
Purity
>96.0%(GC)
Packaging
25g
Price
$158
Updated
2025/07/31
TRC
Product number
E937170
Product name
Ethyl2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J56360
Product name
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate,mixture of cis and trans
Packaging
1g
Price
$12
Updated
2021/12/16
More
Less

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Chemical Properties,Usage,Production

Uses

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate may be employed as a starting reagent for the synthesis of 1-methyl-3-trifluoromethyl-1H-pyrazole-4- carboxylic acid.

General Description

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate has been reported to participate in the microwave-assisted synthesis of ethyl 1-[4-(2,3,3-trichloroacrylamido)phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate.

Synthesis

122-51-0

372-31-6

571-55-1

General procedure for the synthesis of ethyl ethoxy-2-methylene trifluoroacetoacetate from triethyl orthoformate and ethyl trifluoroacetoacetate: ethyl 4,4,4-trifluoro-3-oxobutanoate (30 g, 162.9 mmol) was added to a solution of acetic anhydride (50 mL) containing triethoxymethane (72.4 g, 488.8 mmol). The reaction mixture was stirred continuously at 135 °C for 18 hours. Upon completion of the reaction, the brown mixture was concentrated to afford ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (38 g, 97.1% yield), the product was a brown oil that could be used in subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.23-1.33 (m, 3H), 1.40 (dt, J = 14.18, 7.19 Hz, 3H), 4.19-4.36 (m, 4H), 7.66-7.87 (m, 1H).

References

[1] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[2] Patent: US2018/170909, 2018, A1. Location in patent: Paragraph 0824; 0825
[3] Patent: CN106432183, 2017, A. Location in patent: Paragraph 0031; 0032
[4] Patent: WO2016/151403, 2016, A1. Location in patent: Paragraph 00520
[5] Journal of Molecular Structure, 2018, vol. 1171, p. 631 - 638

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate Suppliers

Americas 1 Belgium 1 China 118 Europe 1 Germany 4 India 6 Japan 1 Russia 1 Switzerland 1 United Kingdom 11 United States 30 Global 175
Shanghai Chemart Chemical Technology Co., Ltd.
Tel
021-021-50400622 15618790390
Email
info@chemart.cn
Country
China
ProdList
239
Advantage
58
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Nanjing Kaitian Chemical Co., Ltd.
Tel
+86 (25) 5860-8846
Fax
+86 (25) 5860-8846
Email
kt_chem@126.com
Country
China
ProdList
218
Advantage
62
Changzhou Wanyao Biotechnology Co., Ltd.
Tel
0519-89185693 15312551983
Fax
0519-89185693
Email
2410037592@qq.com
Country
China
ProdList
261
Advantage
55
Sci General Material & Chemical Ltd
Tel
021-58388037;21-58388037 13472507714
Email
35177634@qq.com;1589045147@qq.com
Country
China
ProdList
803
Advantage
55
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shenyang Yuancheng Pharmaceutical Technology Co., Ltd.
Tel
024-31298370 15040047923
Fax
024-62665110
Email
yuanchengchem@163.com
Country
China
ProdList
252
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Tianjin Olefin Pharmaceutical Co., Ltd.
Tel
022-022-23301225 18202662021
Fax
022-25541300
Email
Mingmingxuetsu@163.com
Country
China
ProdList
313
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9986
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Changzhou Idea-Works Medical Technology Co., Ltd
Tel
0519-83879978
Email
sales@ideaworkspharm.com
Country
China
ProdList
85
Advantage
62
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Shanghai JingSi Biological Technology Co., Ltd
Tel
18221840760
Fax
QQ:2990760589
Email
2990760589@qq.com
Country
China
ProdList
241
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
9939
Advantage
58
Shanghai Changer Pharmaceutical Technology Co. Ltd.
Tel
15921595598
Email
qd.yu@pharmachanger.com
Country
China
ProdList
468
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Shanghai Chenghe Medical Technology Co. Ltd.
Tel
021-021-54382182 18601603956
Email
18601603956@163.com
Country
China
ProdList
1255
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
More
Less

View Lastest Price from Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate manufacturers

Career Henan Chemical Co
Product
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate 571-55-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

571-55-1, Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetateRelated Search:

3-（trifluoromethyl) Cinnamaldehyde Ethyl methacrylate ETHYL 2-CYANOACRYLATE Ethyl 4-bromoacetoacetate 3-(Trifluoromethyl)benzaldehyde Ethyl acetoacetate Ethyl 4,4,4-trifluoroacetoacetate 2-Hydroxyethyl acrylate acetic acid, triethoxy-, ethyl ester Ethyl propiolate Ethyl acrylate POLY(ETHYL ACRYLATE) Phenylmethylsulfonyl fluoride Trifluoromethanesulfonic anhydride Ethylparaben 2-Methylbenzotrifluoride Ethyl 2-methylacetoacetate Ethanol

  • ETHYL 3-ETHOXY-2-(2,2,2-TRIFLUOROACETYL)ACRYLATE
  • ETHYL 2-(ETHOXYMETHYLENE)-4,4,4-TRIFLUORO-3-OXOBUTYRATE
  • ETHYL 2-(ETHOXYMETHYLENE)-4,4,4-TRIFLUOROACETOACETATE
  • ETHYL ETHOXYMETHYLENE-3-OXO-4,4,4-TRIFLUOROBUTYRATE
  • ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobu
  • ETHYL 2-(ETHOXYMETHYLENE)-4,4,4-TRIFLUOR O-3-OXOBUTYRATE, 96%, CIS AND TRANS
  • ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate,mixture of cis and trans
  • Ethyl 2-(ethoxymethylene)-3-oxo-4,4,4-trifluorobutyrate 97%
  • Ethyl 2-(ethoxymethylene)-4,4,4-
  • ETHYL ETHOXYMETHYLENE-3-OXO-4,4,4-TRIFLUOROBUTYRATE (MIXTURE OF CIS/TRANS ISOMERS)
  • Ethyl 3-ethoxy-2-(2,2,2-trifluoroacetyl)acrylate, Tech.
  • Ethyl 2-(ethoxymethylene)-3-oxo-4,4,4-trifluorobutanoate 97%
  • (E)-ethyl 2-(ethoxyMethylene)-4,4,4-trifluoro-3-oxobutanoate
  • Butanoic acid, 2-(ethoxyMethylene)-4,4,4-trifluoro-3-oxo-, ethyl ester
  • ethyl 2-(ethoxyMethylene)-4,4,4-trifluoro-3-oxobutanoate
  • Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate, mix of cis & trans
  • Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate, 97%, mixture of cis and trans
  • Ethyl 2-[1-ethoxymethylidene]-4,4,4-trifluoro-3-oxo-butyrate
  • (2E)-2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoic acid ethyl ester
  • Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate 97%
  • Ethyl 2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate &gt
  • 2-(Ethoxymethylene)-4,4,4-trifluoro-3-oxobutyric Acid Ethyl Ester
  • 3-Ethoxy-2-(2,2,2-trifluoroacetyl)acrylic Acid Ethyl Ester
  • Ethyl (E)-2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate
  • ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate
  • Ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutyrate,mixture of <i>cis</i> and <i>trans</i>
  • 571-55-1
  • CF3COCCHOC2H5CO2C2H5
  • C9H11F3O4
  • Esters
  • Organic Building Blocks
  • Building Blocks
  • C8 to C9
  • Carbonyl Compounds
  • Small molecule
  • C8 to C9
  • Carbonyl Compounds
  • Esters