Boc-Lys(Boc)-OH

Product Name: Boc-Lys(Boc)-OH
CAS No.: 2483-46-7
Chemical Name: Boc-Lys(Boc)-OH
Synonyms: NSC 164052;BOC-LYS(BOC);BOC-L-LYS(BOC);BOC-LYS(BOC)-OH;Boc-Lys（Boc)-0H;BOC-L-LYSINE(BOC);Boc-L-Lys(Boc)-OH;Na, Ne-Diboc-L-lysine;Nα,ε-Bis-Boc-L-lysine;Boc-Lys(Boc)-OH, 95 %
CBNumber: CB4172901
Molecular Formula: C16H30N2O6
Formula Weight: 346.42
MOL File: 2483-46-7.mol

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Boc-Lys(Boc)-OH Property

Boiling point:: 514.4±45.0 °C(Predicted)
Density: 1.109±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in chloroform, ether, ethyl acetate and methanol
pka: 3.99±0.21(Predicted)
form: Low Melting Solid
color: White
optical activity: -3.22°(C=5.00, MEOH)
InChI: InChI=1S/C16H30N2O6/c1-15(2,3)23-13(21)17-10-8-7-9-11(12(19)20)18-14(22)24-16(4,5)6/h11H,7-10H2,1-6H3,(H,17,21)(H,18,22)(H,19,20)/t11-/m0/s1
InChIKey: FBVSXKMMQOZUNU-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CCCCNC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 2483-46-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003904
Product name: Boc-Lys(Boc)-OH
Purity: AldrichCPR
Packaging: 250MG
Price: $66.1
Updated: 2025/07/31

Usbiological

Product number: 275680
Product name: N-alpha,epsilon-Bis-Boc-L-lysine
Packaging: 50g
Price: $347
Updated: 2021/12/16

TRC

Product number: B656995
Product name: Nα,Nε-Bis-boc-L-lysine
Packaging: 250mg
Price: $40
Updated: 2021/12/16

TRC

Product number: B656995
Product name: Nα,Nε-Bis-boc-L-lysine
Packaging: 1g
Price: $55
Updated: 2021/12/16

Usbiological

Product number: B2526-73
Product name: Na, Ne-bis-Boc-L-lysine
Packaging: 5g
Price: $403
Updated: 2021/12/16

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Boc-Lys(Boc)-OH Chemical Properties,Usage,Production

Chemical Properties

Clear Oil

Uses

Nalpha, Nepsilon-Di-Boc-L-lysine is used as fine chemical intermediate, synthesis intermediates.

Definition

ChEBI: N2,N6-Bis{[(2-methyl-2-propanyl)oxy]carbonyl}lysine is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Synthesis

24424-99-5

657-27-2

2483-46-7

The general procedure for the synthesis of (S)-2,6-di-Boc-aminohexanoic acid from di-tert-butyl dicarbonate and L-lysine hydrochloride was as follows: first, L-lysine hydrochloride was dissolved in 50 mL of a solvent mixture of 1,4-dioxane and water (1:1, v/v), and the pH was adjusted to 10-11 by the dropwise addition of 1 M NaOH solution Next, the pH of L-lysine hydrochloride (2.0 g) was adjusted to 10-11 by slow addition through the addition funnel. Di-tert-butyl dicarbonate (6.0 g) dissolved in 20 mL of dioxane. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and subsequently acidified with 4 M KHSO4 solution to pH=1-2. The acidified solution was extracted twice with ethyl acetate, the organic phases were combined and dried under reduced pressure to give a colorless liquid product in 100% yield.

References

[1] Patent: US2014/127138, 2014, A1. Location in patent: Paragraph 0321; 0322
[2] Patent: US2016/376618, 2016, A1. Location in patent: Paragraph 0206-0212
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1428 - 1436
[4] Patent: WO2014/97178, 2014, A1. Location in patent: Page/Page column 49
[5] New Journal of Chemistry, 2018, vol. 42, # 5, p. 3192 - 3195

Boc-Lys(Boc)-OH Preparation Products And Raw materials

Raw materials

Hexane Di-tert-butyl dicarbonate L-Lysine L-Lysine hydrochloride 1,4-Dioxane Ethyl acetate Sodium hydroxide Potassium bisulfate

Preparation Products

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Boc-Lys(Boc)-OH Suppliers

Canada 2 China 220 Europe 2 Germany 4 India 7 Japan 2 South Korea 1 United Kingdom 8 United States 30 Global 276

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View Lastest Price from Boc-Lys(Boc)-OH manufacturers

Hefei TNJ Chemical Industry Co.,Ltd.

Product: Boc-Lys(Boc)-OH 2483-46-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.8
Supply Ability: 20000
Release date: 2025-08-01

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Lys(Boc)-OH 2483-46-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Career Henan Chemical Co

Product: (S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid 2483-46-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

2483-46-7, Boc-Lys(Boc)-OHRelated Search:

N-Boc-N'-Cbz-L-lysine N-Boc-L-Phenylalaninol BOC-PYR-OET BOC-L-LEUCINOL Boc-Lys-OH 1,1'-Carbonyldiimidazole 6-Aminocaproic acid Carbonyl iron powder BOC-LYS(BOC)-OH DCHA N,N'-Di-Boc-L-lysine hydroxysuccinimide ester BOC-LYS(BOC)-ONP Na, Ne-bis-Boc-L-2-aminoadipamic Acid tert-Butyl Ester NA, NE-BIS-BOC-L-LYSINE TERT-BUTYL ESTER Boc-Lys(Boc)-OH L-LYSINE, N2,N6-BIS[(1,1-DIMETHYLETHOXY)CARBONYL]-N6-METHYL- (S)-N-ALPHA-N'-DI-T-BUTYLOXYCARBONYL-4-PIPERIDYLALANINE BOC-CIS-1,3-AMINO-1-CYCLOHEXANE CARBOXYLIC ACID

N-ALPHA,EPSILON-BIS-BOC-L-LYSINE

N-ALPHA,N-EPSILON-DI-T-BUTOXYCARBONYL-L-LYSINE

BOC-L-LYSINE(BOC)

BOC-L-LYS(BOC)

BOC-LYS(BOC)

BOC-LYS(BOC)-OH

NA, NE-BIS-BOC-L-LYSINE

(S)-2,6-BIS-TERT-BUTOXYCARBONYLAMINO-HEXANOIC ACID

Na, Ne-Diboc-L-lysine

N2,N6-Bis-(tert-butoxycarbonyl)-L-lysine

N2,N6-Bis(tert-butoxycarbonyl)lysine

N2,N6-Bis(tert-butyloxycarbonyl)-L-lysine

N2,N6-Bis[(1,1-dimethylethoxy)carbonyl]-L-lysine

Nα,Nε-Bis(tert-butoxycarbonyl)-L-lysine

N-tert-Butoxycarbonyl-Nε-Boc-L-lysine

2-amino-7-[(2-methylpropan-2-yl)oxy]-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-7-oxoheptanoic acid

Nα,Nε-Bis-Boc-L-Lys-OH

N-beta,epsilon-bis-Boc-L-lysine

Di[N-(tert-butoxycarbonyl)]-L-lysine

NSC 164052

L-Lysine-d4-bis-N-t-BOC

N2,N6-Bis-Boc-L-lysine

Nα, Nε-Bis-boc-L-lysine

N2,N6-Bis-(tert-butoxycarbonyl)-L-lysine ,99%

N<sup>2</sup>,N<sup>6</sup>-Bis-(tert-butoxycarbonyl)-L-lysine

Boc-L-Lys(Boc)-OH

Nα,ε-Bis-Boc-L-lysine≥ 98% (HPLC)

Nalpha,Nepsilon-Di-Boc-L-lysine

(Tert-Butoxy)Carbonyl Lys(Boc)-OH(Syrup)

L-Lysine,N2,N6-bis[(1,1-dimethylethoxy)carbonyl]-

(2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoicaci

(S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid USP/EP/BP

Nα,ε-Bis-Boc-L-lysine

6-Bis-tert-butoxycarbonylaminohexanoic acid

(2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid

TIANFUCHEM--2483-46-7---(S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid

Di-tert-butoxycarbonyl-L-lysine

Boc-Lys(Boc)-OH, 95 %

Lysine Impurity 15 (Di-Boc-L-lysine)

Boc-Lys（Boc)-0H

Nalpha,Nepsilon-Di-Boc-L-lysine 98%

NAlpha, NEpsilon-Bis-boc-L-lysine

2483-46-7

C16H30N2O6

Amino Acid Derivatives

Lysine [Lys, K]

Boc-Amino Acids and Derivative

Amino Acids 13C, 2H, 15N

Boc-Amino acid series

Amino Acids & Derivatives