5-Chloro-7-azaindole
- Product Name
- 5-Chloro-7-azaindole
- CAS No.
- 866546-07-8
- Chemical Name
- 5-Chloro-7-azaindole
- Synonyms
- 5-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;CAS:866546-07-8;5-Chloro-7-azaindol;5-CHLORO-7-AZAINDOLE;5-Chloro-7-azaindole,95%;3-Chloro-7H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-chloro-;5-Chloro-1H-pyrrolo[2,3-b]pyridine >5-Chloro5-Chloro-7-azaindole-7-azaindole;5-Chloro-7-azaindole ISO 9001：2015 REACH
- CBNumber
- CB4179960
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 866546-07-8.mol
5-Chloro-7-azaindole Property
- Melting point:
- 161-162°C
- Density
- 1.425±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 12.97±0.40(Predicted)
- form
- Powder
- color
- White to pale brown
- InChI
- InChI=1S/C7H5ClN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
- InChIKey
- MFZQJIKENSPRSJ-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC(Cl)=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- ADE000883
- Product name
- 5-Chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- C2996
- Product name
- 5-Chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- C2996
- Product name
- 5-Chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- C381193
- Product name
- 5-Chloro-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC16130
- Product name
- 5-Chloro-7-azaindole
- Packaging
- 1g
- Price
- $52.5
- Updated
- 2021/12/16
5-Chloro-7-azaindole Chemical Properties,Usage,Production
Chemical Properties
Yellow powder
Uses
5-Chloro-7-azaindole can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory research and development processes and chemical and pharmaceutical production processes.
Synthesis
1262985-26-1
866546-07-8
Step 3: Synthesis of 5-chloro-7-azaindole (Ib) Under nitrogen protection, 25.0 g of 4-(2-amino-5-chloropyridin-3-yl)-2-methylbut-3-yn-2-ol, 120 mL of N-methylpyrrolidone, and 130 mL of water were added to a 500 mL double jacketed reactor. The mixture was heated to 75-80 °C (jacket temperature about 95 °C) and a vacuum of 350 mbar was applied at about 100 °C. Subsequently, 85 mL of 28% sodium hydroxide aqueous solution was slowly added dropwise over 30-45 minutes at 75-80°C. Upon completion of the dropwise addition, the dropping funnel was rinsed with 5 mL of water and the mixture was stirred at 78-81 °C overnight. The jacket temperature and vacuum need to be adjusted during stirring to maintain a steady distillate flow rate. Under typical laboratory conditions, 50 mL of the water/acetone mixture can be distilled in approximately 2 hours. Continuous water replenishment is required during the reaction to keep the reaction volume constant at about 270 mL. After the reaction is complete, the mixture is cooled to 50-55 °C and 60 mL of toluene is added. The two-phase mixture was stirred at 50-55 °C for 15-30 min, followed by standing for 15-30 min to separate the layers. After separating the aqueous layer, the aqueous layer was extracted with 3 x 50 mL of toluene at 50-55°C. The toluene layers were combined and washed with 5 x 40 mL of water at 50-55°C. The toluene layer was concentrated to dryness and the residue (17.3 g) was recrystallized with 90 mL of toluene to give 13.0 g (71% yield) of 5-chloro-7-azaindole (Ib) as light yellow crystals with an HPLC purity of 96.7% (% area).
References
[1] Patent: US2011/28511, 2011, A1. Location in patent: Page/Page column 14
5-Chloro-7-azaindole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-7-azaindole Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 5-Chloro-7-azaindole manufacturers
- Product
- 5-Chloro-7-azaindole 866546-07-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-13
- Product
- 5-Chloro-7-azaindole 866546-07-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22
- Product
- 5-Chloro-7-azaindole 866546-07-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04