ChemicalBook > CAS DataBase List > 2-Thiophenecarbonyl chloride

2-Thiophenecarbonyl chloride

Product Name
2-Thiophenecarbonyl chloride
CAS No.
5271-67-0
Chemical Name
2-Thiophenecarbonyl chloride
Synonyms
THIOPHENE-2-CARBONYL CHLORIDE;2-thiophene chloride;2-THIOPHENOYL CHLORIDE;SKL1317;INDIP-024;AKOS 92490;AKOS BBS-00003924;2-Theonyl Chloride;2-THENOYL CHLORIDE;A-THENOYL CHLORIDE
CBNumber
CB4181033
Molecular Formula
C5H3ClOS
Formula Weight
146.59
MOL File
5271-67-0.mol
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2-Thiophenecarbonyl chloride Property

Boiling point:
206-208 °C (lit.)
Density 
1.371 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.590(lit.)
Flash point:
195 °F
storage temp. 
2-8°C
solubility 
Chloroform
form 
Liquid
Specific Gravity
1.371
color 
Clear colorless to yellow-gray
Sensitive 
Moisture Sensitive
BRN 
110145
InChIKey
QIQITDHWZYEEPA-UHFFFAOYSA-N
CAS DataBase Reference
5271-67-0(CAS DataBase Reference)
NIST Chemistry Reference
2-Thiophenecarbonyl chloride(5271-67-0)
EPA Substance Registry System
2-Thiophenecarbonyl chloride (5271-67-0)
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Safety

Hazard Codes 
C
Risk Statements 
34-37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
8
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
288985
Product name
2-Thiophenecarbonyl chloride
Purity
97%
Packaging
25g
Price
$60.1
Updated
2025/07/31
Sigma-Aldrich
Product number
288985
Product name
2-Thiophenecarbonyl chloride
Purity
97%
Packaging
100g
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
T0177
Product name
2-Thenoyl Chloride
Purity
>99.0%(T)
Packaging
25g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
T0177
Product name
2-Thenoyl Chloride
Purity
>99.0%(T)
Packaging
100g
Price
$151
Updated
2025/07/31
TCI Chemical
Product number
T0177
Product name
2-Thenoyl Chloride
Purity
>99.0%(T)
Packaging
500g
Price
$601
Updated
2025/07/31
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2-Thiophenecarbonyl chloride Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW-GREY LIQUID

Uses

2-Thiophenecarbonyl chloride was used in the synthesis of building blocks derived from ornithine by undergoing acylation/sulphonation of copper complex of orthinine.

Uses

2-Thiophenecarbonyl Chloride is used in the synthesis of substituted pyridines as selective and highly effective GPR119 agonists. It is also seen in the preparation of diuretics.

General Description

The postfunctionalization reaction of 2-thiophenecarbonyl chloride with single walled carbon nanotubes (SWCNTs) was studied.

Synthesis

88-15-3

5271-67-0

The general procedure for the synthesis of 2-thiophenecarbonyl chloride from 2-acetylthiophene was as follows: to a mixed solution containing 2-acetylthiophene (0.108 mL, 1.0 mmol), pyridine (0.016 mL, 0.20 mmol), and chlorobenzene (0.35 mL), disulfur dichloride (S2Cl2, 0.16 mL, 2.0 mmol) was slowly added at room temperature (S2Cl2, 0.16 mL, 2.0 mmol), while stirring continuously. After the reaction mixture was stirred for 1 hour and 45 minutes, sulfuryl chloride (SO2Cl2, 0.162 mL, 2.0 mmol) was added dropwise, followed by continued stirring for 0.5 hours at room temperature. Next, the reaction mixture was heated to 132 °C and stirred at this temperature for 14 hours. Upon completion of the reaction, the reaction mixture was diluted with deuterated chloroform (CDCl3, 2 mL) and the internal standard (tributyl phosphate, 1BU3PO4, 0.0552 mL, 0.20 mmol) was added for nuclear magnetic resonance (1H NMR) analysis. The analytical results showed that the yield of 2-thiophenecarbonyl chloride was 90%.

References

[1] Patent: WO2017/5606, 2017, A1. Location in patent: Page/Page column 31-32
[2] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10370 - 10374
[3] Patent: WO2016/150937, 2016, A1. Location in patent: Page/Page column 27
[4] Patent: WO2016/202757, 2016, A1. Location in patent: Page/Page column 30; 31
[5] Patent: TW2017/36360, 2017, A

2-Thiophenecarbonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

ETHYL 2-[(2-THIENYLCARBONYL)AMINO]ACETATE 2-Thienyl isocyanate
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View Lastest Price from 2-Thiophenecarbonyl chloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Thiophenecarbonyl chloride 5271-67-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Henan Aochuang Chemical Co.,Ltd.
Product
2-Thiophenecarbonyl chloride 5271-67-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Hebei Yanxi Chemical Co., Ltd.
Product
2-Thiophenecarbonyl chloride 5271-67-0
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-10

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