1-HYDROXYPIPERIDINE

Product Name: 1-HYDROXYPIPERIDINE
CAS No.: 4801-58-5
Chemical Name: 1-HYDROXYPIPERIDINE
Synonyms: 1-piperidinol;piperidin-1-ol;Hydroxypiperidine;1-HYDROXYPIPERDINE;1-hydroxy-piperidin;N-HYDROXYPIPERIDINE;1-HYDROXYPIPERIDINE;Piperidine, 1-hydroxy-;Bupivacaine Impurity 27;1-HYDROXYPIPERIDINE 96+%
CBNumber: CB4185440
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 4801-58-5.mol

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1-HYDROXYPIPERIDINE Property

Melting point:: 37-39 °C
Boiling point:: 146-148℃ (1 Torr)
Density: 0.9903 (rough estimate)
refractive index: 1.4550 (estimate)
Flash point:: 78 °C
storage temp.: 2-8°C
pka: 14.19±0.20(Predicted)
form: low melting solid
color: White
BRN: 102726
InChIKey: LKPFBGKZCCBZDK-UHFFFAOYSA-N
EPA Substance Registry System: Piperidine, 1-hydroxy- (4801-58-5)

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Safety

WGK Germany: 3
RTECS: TN6829550
F: 3-10
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 56207
Product name: 1-Hydroxypiperidine
Purity: ≥96.0% (GC)
Packaging: 1g
Price: $146
Updated: 2025/07/31

Apolloscientific

Product number: OR961933
Product name: 1-Hydroxypiperidine
Purity: 95%
Packaging: 1g
Price: $140
Updated: 2021/12/16

Apolloscientific

Product number: OR961933
Product name: 1-Hydroxypiperidine
Purity: 95%
Packaging: 5g
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0006758
Product name: 1-HYDROXYPIPERIDINE
Purity: 95.00%
Packaging: 1G
Price: $674.05
Updated: 2021/12/16

Crysdot

Product number: CD11117996
Product name: Piperidin-1-ol
Purity: 95+%
Packaging: 1g
Price: $70
Updated: 2021/12/16

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1-HYDROXYPIPERIDINE Chemical Properties,Usage,Production

Chemical Properties

Soluble in water, organic solvents, aqueous acids, and bases.

Uses

Base for Fmoc-based solid phase peptide synthesis

Light stabilizing agent

Uses

Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012

Synthesis

110-89-4

4801-58-5

General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine.

References

[1] Synlett, 2017, vol. 28, # 17, p. 2315 - 2319
[2] Tetrahedron Letters, 2001, vol. 42, # 20, p. 3419 - 3422
[3] Justus Liebigs Annalen der Chemie, 1948, vol. 559, p. 1,22, 23
[4] Chemische Berichte, 1951, vol. 84, p. 690,698
[5] Chemische Berichte, 1892, vol. 25, p. 2782

1-HYDROXYPIPERIDINE Preparation Products And Raw materials

Raw materials

1-Ethylpiperidine

Preparation Products

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1-HYDROXYPIPERIDINE Suppliers

China 63 Europe 2 Germany 1 India 1 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 9 Global 81

Aladdin Scientific

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Combi-Blocks Inc.

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ChemService Inc.

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3B Scientific Corporation

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HONEST JOY HOLDINGS LIMITED

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Alfa Aesar

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Pfaltz & Bauer, Inc.

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View Lastest Price from 1-HYDROXYPIPERIDINE manufacturers

Career Henan Chemical Co

Product: 1-HYDROXYPIPERIDINE 4801-58-5
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

4801-58-5, 1-HYDROXYPIPERIDINERelated Search:

4-BENZOYLOXY-TEMPO 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy 4-Amino-TEMPO, free radical 4-ACETAMIDO-TEMPO 1-HYDROXYPIPERIDINE 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl 4-Oxo-2,2,6,6-tetramethylpiperidinooxy 2,2,6,6-Tetramethylpiperidinooxy SCOPOLAMINE N-OXIDE HYDROBROMIDE 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Light Stabilizer UV-622 DL-Pipecolinic acid 4-(4-Chlorophenyl)-4-hydroxypiperidine, crystalline, 99+% N-BOC-4-Hydroxypiperidine (R)-4-HYDROXY-PIPERIDIN-2-ONE Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate 4-[4-Chloro-3-(trifluoro methyl)phenyl]-4-hydroxypiperidine 4-HYDROXY-4-PHENYLPIPERIDINE

1-HYDROXYPIPERIDINE

N-HYDROXYPIPERIDINE

1-hydroxy-piperidin

1-piperidinol

piperidin-1-ol

1-HYDROXYPIPERIDINE 96+%

1-HYDROXYPIPERDINE

Hydroxypiperidine

1-Piperidinol/1-hydroxypiperidine

Piperidine, 1-hydroxy-

Bupivacaine Impurity 27

1-Hydroxypiperidine >=96.0% (GC)

4801-58-5

Piperidines

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C5 to C7

Chemical Synthesis

Heterocyclic Building Blocks

Piperidines