Pictilisib
- Product Name
- Pictilisib
- CAS No.
- 957054-30-7
- Chemical Name
- Pictilisib
- Synonyms
- CS-23;RG7321;GDC-01;GNE0941;GDC-0941;GNE 0941;GNE-0941;Pictilisib;pictrelisib;GDC-0941 Base
- CBNumber
- CB41872141
- Molecular Formula
- C23H27N7O3S2
- Formula Weight
- 513.64
- MOL File
- 957054-30-7.mol
Pictilisib Property
- Melting point:
- >200oC (dec.)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- White powder solid.
- pka
- 12.22±0.40(Predicted)
- color
- White/off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11600
- Product name
- GDC-0941
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 11600
- Product name
- GDC-0941
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $333
- Updated
- 2024/03/01
- Product number
- 11600
- Product name
- GDC-0941
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $531
- Updated
- 2024/03/01
- Product number
- orb61040
- Product name
- GDC-0941, Free Base
- Purity
- >99% pure
- Packaging
- 100mg
- Price
- $493
- Updated
- 2021/12/16
- Product number
- orb61040
- Product name
- GDC-0941, Free Base
- Purity
- >99% pure
- Packaging
- 50mg
- Price
- $343.4
- Updated
- 2021/12/16
Pictilisib Chemical Properties,Usage,Production
Description
GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4
Uses
GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.
Definition
ChEBI: A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.
target
PI3Kα
References
1) Folkes?et al.?(2008),?The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;? J.?Med. Chem.,?51?5522 2) Raynaud?et al. (2009),?Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther.,?8?1725 3) Knapp et al. (2013),?A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol.,?9?3 4) Sarker?et al. (2015),?First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res.,?21?77
Pictilisib Preparation Products And Raw materials
Raw materials
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View Lastest Price from Pictilisib manufacturers
- Product
- Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- 957054-30-7
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23