Pictilisib

ChemicalBook > CAS DataBase List > Pictilisib

Product Name: Pictilisib
CAS No.: 957054-30-7
Chemical Name: Pictilisib
Synonyms: CS-23;RG7321;GDC-01;GNE0941;GDC-0941;GNE 0941;GNE-0941;Pictilisib;pictrelisib;GDC-0941, >=98%
CBNumber: CB41872141
Molecular Formula: C23H27N7O3S2
Formula Weight: 513.64
MOL File: 957054-30-7.mol

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Pictilisib Property

Melting point:: >200oC (dec.)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: White powder solid.
pka: 12.22±0.40(Predicted)
color: White/off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11600
Product name: GDC-0941
Purity: ≥98%
Packaging: 10mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 11600
Product name: GDC-0941
Purity: ≥98%
Packaging: 50mg
Price: $333
Updated: 2024/03/01

Cayman Chemical

Product number: 11600
Product name: GDC-0941
Purity: ≥98%
Packaging: 100mg
Price: $531
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb61040
Product name: GDC-0941, Free Base
Purity: >99% pure
Packaging: 100mg
Price: $493
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb61040
Product name: GDC-0941, Free Base
Purity: >99% pure
Packaging: 50mg
Price: $343.4
Updated: 2021/12/16

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Pictilisib Chemical Properties,Usage,Production

Description

GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC -0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models.

Definition

ChEBI: A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.

target

PI3Kα

References

1) Folkes?et al.?(2008),?The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;? J.?Med. Chem.,?51?5522 2) Raynaud?et al. (2009),?Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther.,?8?1725 3) Knapp et al. (2013),?A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol.,?9?3 4) Sarker?et al. (2015),?First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res.,?21?77

Pictilisib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pictilisib Suppliers

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View Lastest Price from Pictilisib manufacturers

Career Henan Chemical Co

Product: Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- 957054-30-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

957054-30-7, PictilisibRelated Search:

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Pictilisib

Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-

GDC-0941

GDC-0941 free base

2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine

GDC-0941 bismesylate

2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

4-(2-(1H-Indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]

4-{6-[(4-Methanesulfonylpiperazin-1-yl)Methyl]-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidin-2-yl}-1H-indazole

4-(2-(1H-indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]pyriMidin-4-yl)Morpholine

2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrim

2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

RG7321

2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941

GDC-0941 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine

GDC-0941 (Pictilisib)

pictrelisib

GDC-0941;GDC 0941;GDC0941

2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]py

GDC-0941, >=98%

Pictilisib, 98%, a potent inhibitor of PI3Kα/δ

GDC0941; GDC 0941; RG7321

GDC-0941;GDC 0941

CS-23

GDC-01

Pictilisib (GDC0941, RG7321, GNE0941))

4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)me...

PI 3-K Inhibitor XXI GDC-0941 GDC0941

GNE 0941

GNE0941

GNE-0941

957054-30-7

C23H27N7O3S2

An inhibitor of class I PI3 kinase (PI3K).

Inhibitors

Akt

mTOR

PI3K