CONVALLATOXIN
- Product Name
- CONVALLATOXIN
- CAS No.
- 508-75-8
- Chemical Name
- CONVALLATOXIN
- Synonyms
- Convapur;orglycon;CORGLYKON;Convalpur;corglycon;korglykon;NSC 407808;corglycone;Convallopan;convallaton
- CBNumber
- CB4190741
- Molecular Formula
- C29H42O10
- Formula Weight
- 550.64
- MOL File
- 508-75-8.mol
CONVALLATOXIN Property
- Melting point:
- 238-239℃ (water )
- alpha
- D22 -1.7 ± 3° (c = 0.65 in methanol); D25 -9.4 ± 3° (c = 0.72 in dioxane)
- Boiling point:
- 542°C (rough estimate)
- Density
- 1.41±0.1 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.5376 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.04±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- Merck
- 13,2538
- Stability:
- Hygroscopic
- InChIKey
- HULMNSIAKWANQO-BUBSWJANNA-N
Safety
- RIDADR
- 3249
- WGK Germany
- 2
- RTECS
- GL4025000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 508-75-8(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (Frster)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C9140
- Product name
- Convallatoxin
- Purity
- ≥65%
- Packaging
- 100mg
- Price
- $170
- Updated
- 2025/07/31
- Product number
- C685075
- Product name
- Convallatoxin
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC137904
- Product name
- Convallatoxin
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC137904
- Product name
- Convallatoxin
- Packaging
- 2mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC137904
- Product name
- Convallatoxin
- Packaging
- 5mg
- Price
- $255
- Updated
- 2021/12/16
CONVALLATOXIN Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder. Melting point 235-242°C. Soluble in alcohol and acetone, slightly soluble in water and chloroform, practically insoluble in ether and petroleum ether.
Originator
Convallatoxin,C-Strong Co., Ltd.
Uses
Convallatoxin is a cardenolide that is used in the treatment of congestive heart failure. It may also be used in the treatment of tumor cells at nanomolar concentrations due to its anti-proliferative effects
Definition
ChEBI: A cardenolide glycoside that consists of strophanthidin having a 6-deoxy-alpha-L-mannopyranosyl (L-rhamnosyl) group attached at position 3.
Manufacturing Process
1 part of grinded flowers Convallaria majalis and 12 parts of water was stirred
for 15 hours at ambient temperature. After a filtration and washing with
water, a clear brown filtrate was mixed with a concentrate solution of lead
acetate. A lead consisted precipitate was filtered off and sodium phosphate
was added to filtrate for removing the remaining lead. The solution was
filtered again and 0.5 - 0.6 parts of a coal was added and the mixture was
stirred for 3 hours at ambient temperature. The coal was filtered off, washed
with a little water and dried at 30°-40°C. A hot CHCl3 was added to dry coal
adsorbent. CHCl3 was distilled off to dryness in vacuum. The residue was
dissolved in a little methanol and the obtained solution was shook 3 times
with 2 volumes of petrol ether and then distilled to dryness in vacuum. This
product was dissolved in minimum absolute ethanol and added to 10 volumes
of dry ether. The formed precipitate was filtered and washed with ether to
give the glycoside as a gray powder. It was crystallized from diluted ethanol
as colorless needles.
Therapeutic Function
Cardiotonic
Biological Activity
A cardiac glycoside found in lily-of-the-valley with digitalis-like cardiac effects.
Purification Methods
Crystallise convallatoxin from EtOAc, CHCl3/EtOH (9:1) or MeOH/Et2O. The tetraacetate has m 238-242o (from MeOH/Et2O), [] D 25 -5o (CHCl3). [Reyle et al. Helv Chim Acta 33 1541 1950, Fieser & Jacobson J Am Chem Soc 59 2335 1937 Beilstein 1 8 III/IV 3142.]
CONVALLATOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CONVALLATOXIN manufacturers
- Product
- CONVALLATOXIN 508-75-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-25