2-Amino-4-hydroxy-6-phenylpyrimidine

Product Name: 2-Amino-4-hydroxy-6-phenylpyrimidine
CAS No.: 56741-94-7
Chemical Name: 2-Amino-4-hydroxy-6-phenylpyrimidine
Synonyms: NSC42141;NSC212187;T0515-8624;ZINC00040022;ZINC04555874;Oprea1_175017;AF-936/31346025;ChemDiv2_000111;BUTTPARK 44\01-63;6-Phenylisocytosine
CBNumber: CB4203991
Molecular Formula: C10H9N3O
Formula Weight: 187.2
MOL File: 56741-94-7.mol

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2-Amino-4-hydroxy-6-phenylpyrimidine Property

Melting point:: 295 °C
Boiling point:: 374.5±45.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 9.15±0.50(Predicted)
color: White to Almost white
CAS DataBase Reference: 56741-94-7(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2123
Product name: 6-Phenylisocytosine
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $105
Updated: 2025/07/31

TCI Chemical

Product number: P2123
Product name: 6-Phenylisocytosine
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $315
Updated: 2025/07/31

TRC

Product number: A612465
Product name: 2-Amino-4-hydroxy-6-phenylpyrimidine
Packaging: 250mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: Q460
Product name: 2-Amino-4-hydroxy-6-phenylpyrimidine
Packaging: 5g
Price: $330
Updated: 2021/12/16

Matrix Scientific

Product number: 066110
Product name: 2-Amino-6-phenylpyrimidin-4(3H)-one
Packaging: 500mg
Price: $237
Updated: 2021/12/16

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2-Amino-4-hydroxy-6-phenylpyrimidine Chemical Properties,Usage,Production

Uses

2-Amino-4-hydroxy-6-phenylpyrimidine has been utilized in the investigation of 2-aminopyrimidines as potential non-natural nucleobase analogues.

Synthesis

94-02-0

56741-94-7

Intermediate 1A: Preparation of 4-chloro-6-phenylpyrimidin-2-amine; Guanidine carbonate (3.60 g, 20 mmol) was suspended in ethanol (120 mL) and toluene (20 mL) and refluxed under nitrogen protection for 1 hour, during which time about 50 mL of solvent was removed by distillation. After the mixture was cooled to 45 °C, ethyl 3-oxo-3-phenylpropionate (7.68 g, 40 mmol) was added and refluxing was continued with heat overnight. During the reaction, the target product precipitated as a white solid. Water (50 mL) was added and reflux was continued for 30 minutes. After cooling to room temperature, the reaction mixture was neutralized with 1N HCl and allowed to stand in a refrigerator for 6 hours. The solid was collected by filtration, washed sequentially with water and ether, and dried under vacuum at 60 °C to give a white solid product (6.45 g, 86% yield). Mass spectrometry (MS ES): m/z 188 ([M + H]+, calculated value 188); measured value: 188. retention time (RT) = 0.91 min; thin-layer chromatography (TLC, unfolding reagent was 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.10. The above product (6.0 g, 32 mmol) was mixed with POCl3 (100 mL) was mixed and heated to reflux for 1 hr. Decompression distillation removed most of the POCl3 and the residue was diluted with EtOAc and poured into ice/saturated NaHCO3 solution. The aqueous layer was extracted with EtOAc, the organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was recrystallized by EtOAc/ether to give the off-white powdery product 1A (2.8 g, 43% yield). Mass spectrometry analysis (MS ES): m/z 206 ([M + H]+, calculated value 206); retention time (RT) = 2.49 min; thin-layer chromatography (TLC, unfolding agent is 95/5 MeOH solution of CH2Cl2/2M NH3) Rf = 0.72. (Ref. 1: H.L. Skulnick, S.D. Weed, E.E. Edison, H.E. Renis, W. Wierenga, and D.A. Stringfellow, J. Med. Chem. 1985, 28, 1854-1869).

References

[1] Patent: WO2005/35507, 2005, A2. Location in patent: Page/Page column 52

2-Amino-4-hydroxy-6-phenylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-hydroxy-6-phenylpyrimidine Suppliers

Canada 1 China 88 Germany 1 India 2 Japan 1 Russia 1 The Netherlands 1 United Kingdom 9 United States 15 Global 119

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View Lastest Price from 2-Amino-4-hydroxy-6-phenylpyrimidine manufacturers

Dideu Industries Group Limited

Product: 2-Amino-4-hydroxy-6-phenylpyrimidine 56741-94-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-17

Career Henan Chemical Co

Product: 2-Amino-4-hydroxy-6-phenylpyrimidine 56741-94-7
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

56741-94-7, 2-Amino-4-hydroxy-6-phenylpyrimidineRelated Search:

3-Aminophenol CHLOROPHOSPHONAZO III Glycine 2-Aminopyrimidine 6-Aminocaproic acid Acetaminophen EC 2.6.1.2 Isocytosine ALTRENOGEST Glucosamine 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Tris(hydroxymethyl)aminomethane 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Phenylacetone 2-Amino-4-hydroxy-6-phenylpyrimidine AMINO ACIDS 2-(5-OXO-3-PHENYL-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE 2-(4-BENZYL-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE

BUTTPARK 44\01-63

2-AMINO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-amino-6-phenyl-4(3H)-Pyrimidinone

2-Amino-6-phenylpyrimidin-4-ol

2-amino-6-phenyl-1H-pyrimidin-4-one

2-azanyl-6-phenyl-1H-pyrimidin-4-one

2-Amino-6-phenylpyrimidin-4(3H)-one

4(3H)-Pyrimidinone, 2-amino-6-phenyl-

6-Phenylisocytosine

2-Amino-6-phenyl-4(1H)-pyrimidinone

AF-936/31346025

ChemDiv2_000111

NSC212187

NSC42141

Oprea1_175017

SDCCGMLS-0065515.P001

T0515-8624

ZINC00040022

ZINC04555874

4(1H)-Pyrimidinone, 2-amino-6-phenyl-

2-Amino-6-phenyl-4(3H)-pyrimidone

6-Phenylisocytosine &gt

2-Amino-4-hydroxy-6-phenylpyrimidine ISO 9001：2015 REACH

56741-94-7

59741-94-7

C10H9N3O2

Pyrimidines

Fluorobenzene