5-Methoxyindole

Product Name: 5-Methoxyindole
CAS No.: 1006-94-6
Chemical Name: 5-Methoxyindole
Synonyms: 5-METHOXY-1H-INDOLE;Methoxyindole 99% indol-5-yl methyl ether;5-methoxy-indol;Femedol;NSC 521752;AKOS JY2082918;5-METHOXYINDOLE;methoxy-5indole;5-MethoxyindoleF;Methoxy-5 indole
CBNumber: CB4223553
Molecular Formula: C9H9NO
Formula Weight: 147.17
MOL File: 1006-94-6.mol

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5-Methoxyindole Property

Melting point:: 52-55 °C (lit.)
Boiling point:: 176-178 °C/17 mmHg (lit.)
Density: 1.1135 (rough estimate)
refractive index: 1.5310 (estimate)
Flash point:: 176-178°C/17mm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
pka: 16.70±0.30(Predicted)
form: Crystalline Powder
color: White to light brownish
Water Solubility: insoluble
Sensitive: Light Sensitive
BRN: 116722
InChI: 1S/C9H9NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-6,10H,1H3
InChIKey: DWAQDRSOVMLGRQ-UHFFFAOYSA-N
SMILES: COc1ccc2[nH]ccc2c1
CAS DataBase Reference: 1006-94-6(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Indole, 5-methoxy-(1006-94-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25-37/39
WGK Germany: 3
RTECS: NL9500000
F: 8
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD, LIGHT SENSITIVE
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M14900
Product name: 5-Methoxyindole
Purity: 99%
Packaging: 1g
Price: $26.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: M14900
Product name: 5-Methoxyindole
Purity: 99%
Packaging: 5g
Price: $36.5
Updated: 2025/07/31

TCI Chemical

Product number: M0731
Product name: 5-Methoxyindole
Purity: >99.0%(GC)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: M0731
Product name: 5-Methoxyindole
Purity: >99.0%(GC)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: M0731
Product name: 5-Methoxyindole
Purity: >99.0%(GC)
Packaging: 25g
Price: $222
Updated: 2025/07/31

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5-Methoxyindole Chemical Properties,Usage,Production

Chemical Properties

white to light brownish crystalline powder

Uses

5-Methoxyindole (cas# 1006-94-6) is a compound useful in organic synthesis. It can be used to synthesis 1-(Phenylsulfonyl)-5-methoxy-1H-indole.

Preparation

The synthesis of 5-methoxyindole from 5-methoxy-2-oxindole: Conversion of 5-methoxy-2-oxindole to 5-methoxyindole was accomplishedby the chlorination of 5-methoxy-2-oxindole with triphenylphosphine-carbontetrachloride in acetonitrile followed by the catalytic reduction of a chlorine atom in 66% total yield.

Definition

ChEBI: 5-methoxyindole is a member of indoles.

Reactions

5-methoxyindole was treated with sodium hydroxide and phenylsulfonyl chloride in the presence of a catalytic amount of tetrabutylammonium bromide to afford 1-(phenylsulfonyl)indole and 5-methoxy-1-(phenylsufonyl)indole in excellent yields of 100%.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 1405, 1989 DOI: 10.1002/jhet.5570260533
The Journal of Organic Chemistry, 58, p. 5558, 1993 DOI: 10.1021/jo00072a052
Tetrahedron Letters, 27, p. 837, 1986 DOI: 10.1016/S0040-4039(00)84114-3

Synthesis

The synthesis method of 2-pyridinecarboxaldehyde:the three-component coupling reaction of dicarbonyl compounds, aldehydes, and urea/thiourea catalyzed by indium chloride can be efficiently synthesized.

Purification Methods

Crystallise 5-methoxyindole from cyclohexane pet ether or pet ether/Et2O. [Saito & Kikugawa J Heterocycl Chem 16 1325 1979, Beilstein 21 III/IV 765, 21/3 V 18.]

5-Methoxyindole Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHOXY-DL-TRYPTOPHAN 5-METHOXYGRAMINE

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5-Methoxyindole Suppliers

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View Lastest Price from 5-Methoxyindole manufacturers

LAURENT

Product: 5-Methoxyindole 1006-94-6
Price: US $4064.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-20

LAURENT

Product: 5-Methoxyindole 1006-94-6
Price: US $4064.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2025-11-20

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-METHOXYINDOLE 1006-94-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-14

1006-94-6, 5-MethoxyindoleRelated Search:

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Methoxyindole 99% indol-5-yl methyl ether

5-Methoxyindole ,98%

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5-METHOXYINDOLE REPANIDAL

NSC 521752

5-METHOXYINDOLE

AKOS JY2082918

5-METHOXY-1H-INDOLE

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5-Methoxyindole in stock Factory

TIMTEC-BB SBB004094

1H-Indol-5-yl methyl ether

5-methoxy-indol

Femedol

Indole, 5-methoxy-

Methoxy-5 indole

methoxy-5indole

5-Methyoxy Indole

5-methyloxyl indole

5-Methoxylindole

Methoxyindole,99%

Indol-5-yl methyl ether

5-Methoxyindole&gt

5-Methoxyindole 1006-94-6

5-methoxy-1H-indole - [M2323]

1006-94-6

Indoles

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Chemical Synthesis

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